Article
Immunology
LuLu Qian, Jun-Zhao Li, XueMei Sun, Jie-Bin Chen, Ying Dai, Qiu-Xiang Huang, Ying-Ji Jin, Qing-Ning Duan
Summary: The study demonstrates that safinamide can inhibit the production of pro-inflammatory cytokines by macrophages, reduce the release of inflammatory mediators, prevent leukocyte migration, and decrease the generation of related enzymes. These effects are mainly achieved through safinamide's inhibition of the TLR4/NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Evan A. Mulligan, Susan J. Tudhope, Jill E. Hunter, Arabella E. G. Clift, Sarah L. Elliott, Geoffrey P. Summerfield, Jonathan Wallis, Chris J. Pepper, Barabara Durkacz, Stephany Veuger, Elaine Willmore
Summary: This study demonstrates the importance of RelB in CLL, as high basal levels of RelB DNA binding correlate with nuclear RelB protein expression and are associated with poor clinical outcomes. CD40L stimulation promotes RelB activation and CLL cell proliferation. Inhibiting non-canonical NF-kappa B signalling may be a novel therapeutic approach for CLL.
Article
Immunology
Sixuan Guo, Wanyan Li, Feiyue Chen, Shuzhan Yang, Yunmao Huang, Yunbo Tian, Danning Xu, Nan Cao
Summary: This study found that pretreatment with Polysaccharide of Atractylodes macrocephala Koidz (PAMK) could alleviate the histopathological damage caused by LPS-induced liver inflammation in mice. PAMK activated the TLR4-MyD88-NF-κB signaling pathway, reduced levels of IL-1β, IL-6, and TNF-α, increased IL-4 levels, and inhibited GSH-PX and MDA levels, indicating its potential protective role in reducing inflammatory damage and oxidative stress in the liver.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cell Biology
Karli Mockenhaupt, Alexandra Gonsiewski, Tomasz Kordula
Summary: Neuroinflammation involves multiple cell types in the central nervous system, which coordinate their responses by secreting and responding to inflammatory mediators. Critical activation of NF-kappa B pathways is observed during neuroinflammation, with specific mechanisms and roles of RelB activation in different cell types being less understood. This review summarizes the mechanisms of RelB activation in specific cell types within the CNS and its specialized effects during neuroinflammation.
Article
Immunology
Yifan Qu, Xinyi Li, Fengying Xu, Shimin Zhao, Xuemei Wu, Yuzhen Wang, Jiming Xie
Summary: The study demonstrates that kaempferol has significant anti-inflammatory and antioxidant effects in DSS-induced colitis mice, alleviating UC symptoms by modulating the gut microbiota and TLR4-related signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Qiao Zhou, Ding-Xiu He, Yi-Ling Deng, Chun-Li Wang, Lan-Lan Zhang, Fa-Ming Jiang, Laurent Irakoze, Zong-An Liang
Summary: This study found that miR-124-3p has a protective effect on acute lung injury (ALI) by inhibiting the TLR4/NF-kappa B signaling pathway, and miR-124-3p directly targets PDE4B to suppress this signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hao-Yu Che, Chang-Hai Zhou, Chen-Chen Lyu, Yu Meng, Yun-Tong He, Hao-Qi Wang, Hong-Yu Wu, Jia-Bao Zhang, Bao Yuan
Summary: Dairy farming is an important economic activity, and mastitis is a common disease in dairy cows. Allicin, a natural extract from garlic, has various beneficial properties including anti-inflammatory and antibacterial effects. This study found that allicin can reduce inflammation in the mammary epithelial cells of dairy cows, possibly through the TLR4/NF-kappa B signaling pathway. Allicin may be a promising alternative treatment for mastitis in cows.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Rashida Ginwala, Raina Bhavsar, Patrick Moore, Mariana Bernui, Narendra Sing, Frank Bearoff, Mitzi Nagarkatti, Zafar K. Khan, Pooja Jain
Summary: Apigenin reduces EAE severity by shifting T cell responses from T(h)1 and T(h)17 to T(reg) type through modulation of DC activity. This is achieved by decreasing T-bet, IFN-gamma (T(h)1), IL-17 (T(h)17) and increasing IL-10, TGF-beta, and FoxP3 (T-reg) expression.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Cell Biology
Xiaoling Li, Riming Huang, Kaifeng Liu, Mingyue Li, Hui Luo, Liao Cui, Lei Huang, Lianxiang Luo
Summary: Fucoxanthin alleviates lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and the TLR4/MyD88 signaling axis, indicating a potential therapeutic strategy for controlling ALI.
Article
Agriculture, Dairy & Animal Science
Jinbang Xiao, Shanshan Li, Ruixue Zhang, Zongjie Wang, Xinyan Zhang, Aihua Wang, Yaping Jin, Pengfei Lin
Summary: Endometritis is a common reproductive disease in domestic animals caused by Gram-negative bacterial infection, where the ISGylation modification system can regulate the inflammatory response by modulating the TLR4/NF-kappa B signaling pathway. Experimental evidence shows that ISG15 can inhibit LPS-induced inflammatory response through ISGylation.
Article
Chemistry, Medicinal
Man Liu, Ying-Lin Yang, Shan-Shan Zhang, Dong-Ni Liu, Lian-Hua Fang, Guan-Hua Du, Yue-Hua Wang
Summary: The study revealed that RKC-B1 exhibits anti-neuroinflammatory effects in LPS-stimulated mice by modulating multiple inflammatory signaling pathways, suggesting it could be a promising agent for treating neuroinflammation.
Article
Nutrition & Dietetics
Bingyong Mao, Weiling Guo, Xin Tang, Qiuxiang Zhang, Bo Yang, Jianxin Zhao, Shumao Cui, Hao Zhang
Summary: Inosine pre-treatment attenuates LPS-induced pulmonary inflammatory response by regulating the TLR4/MyD88/NF-kappa B signaling pathway and ameliorates intestinal microbiota disorder.
Article
Immunology
Jia Wang, Jingjing Yang, Wenhui Xia, Mengna Zhang, Haonan Tang, Keyi Wang, Chenyu Zhou, Ling Qian, Yuan Fan
Summary: In this study, the functional role of Escherichia coli (E. coli) and its supernatant in regulating the Th17/Treg balance and cytokines and chemokines profile in Oral lichen planus (OLP) immune microenvironment was examined. It was found that E. coli and its supernatant activated the TLR4/NF-kappa B signaling pathway, leading to increased expression of cytokines and chemokines and Th17/Treg imbalance in OLP. Furthermore, E. coli and supernatant promoted T cell proliferation and migration, and induced apoptosis in oral keratinocytes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tobias Riedl, Suzanne Faure-Dupuy, Maude Rolland, Svenja Schuehle, Zohier Hizir, Silvia Calderazzo, Xiaodong Zhuang, Jochen Wettengel, Martin Alexander Lopez, Romain Barnault, Valbona Mirakaj, Sandra Prokosch, Danijela Heide, Corinna Leuchtenberger, Martin Schneider, Bernd Hessling, Benjamin Stottmeier, Isabel M. Wessbecher, Peter Schirmacher, Jane A. McKeating, Ulrike Protzer, David Durantel, Julie Lucifora, Emmanuel Dejardin, Mathias Heikenwalder
Summary: The stabilization of HIF1 alpha was found to inhibit the expression of APOBEC3B and its antiviral effects against HBV. Inhibiting the expression or stabilization of HIF1 alpha could serve as an anti-HBV strategy. High levels of HIF1 alpha may provide a reservoir for HBV survival in immune-active patients, and therefore should be considered as a constraining factor in the development of immune therapies.
Article
Immunology
Xiao-qin Qu, Qiong-feng Chen, Qiao-qing Shi, Qian-qian Luo, Shuang-yan Zheng, Yan-hong Li, Liang-yu Bai, Shuai Gan, Xiao-yan Zhou
Summary: PEBP4 plays an important role in LPS/D-GalN-induced acute liver injury, with its knockout exacerbating liver damage, inflammation, and apoptosis, mediated through the TLR4/NF-κB signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)