Article
Biochemistry & Molecular Biology
Jinming Peng, Guiqiang Liang, Wenjun Wen, Zihui Qiu, Wenye Huang, Qin Wang, Gengsheng Xiao
Summary: This study prepared Penta-O-galloyl-beta-D-glucose (PGG) from tannic acid methanolysis products and investigated its protective effects and mechanism on glucose-induced glycation for the first time. PGG was found to have strong anti-AGEs effects in bovine serum albumin (BSA)-glucose (Glu) and BSA-methylglyoxal (MGO) glycation systems. It inhibits AGEs formation by blocking glycated intermediates, eliminating radicals, and chelating metal ions. Mechanism analysis showed that PGG prevents BSA from glycation by hindering amyloid fibril accumulation, stabilizing BSA secondary structures, and binding partial glycation sites. PGG also displays effective trapping capacities on MGO reactive intermediate. This research suggests PGG as a potential functional ingredient in food materials for preventing diabetic syndrome.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Fengmao An, Yuhan Bai, Xinran Xuan, Ming Bian, Guowei Zhang, Chengxi Wei
Summary: Advanced glycation end products (AGEs) are important risk factors for the development and progression of Alzheimer's disease (AD). 1,8-cineole (CIN) can ameliorate tau phosphorylation and reduce Aβ production by inhibiting the activity of GSK-3β and BACE-1, highlighting its therapeutic potential for AD.
Article
Biochemistry & Molecular Biology
Sauradipta Banerjee
Summary: The study characterized MG-modified myoglobin in a time-dependent manner, with mass spectrometric studies indicating modifications at Lys-87 and Lys-133. Far-UV CD studies revealed alterations in protein structure and surface hydrophobicity as a result of MG modification. These findings suggest that MG-derived AGE adducts significantly impact the structure of Mb.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Nutrition & Dietetics
Yantao Zhao, Yao Tang, Shengmin Sang
Summary: The study found that dietary quercetin significantly reduced MGO and AGEs concentrations in the plasma and tissues of mice, inhibiting AGE formation by trapping MGO and regulating the MGO detoxification systems.
JOURNAL OF NUTRITION
(2021)
Article
Agriculture, Multidisciplinary
Tobias Jost, Christian Henning, Thomas Heymann, Marcus A. Glomb
Summary: This study investigated the manufacturing process of wheat bread rolls and found that the AGE profile was significantly expanded, providing comprehensive mechanistic insights. Analysis of five major German bread types revealed high AGE contents, with major lysine protein modifications including carboxymethyl, carboxyethyl, and formyl lysine.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Reinhart Speeckaert, Joris R. Delanghe, Marijn M. Speeckaert
Summary: Advanced glycation end products (AGEs) are compounds formed by nonenzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. These AGEs can alter protein structure and activate the receptor for advanced glycation end products (RAGE). RAGE is expressed by various cells and plays a role in chronic inflammatory autoimmune disorders. Soluble RAGE (sRAGE) acts as a decoy and inhibits pro-inflammatory processes mediated by RAGE. AGE overproduction, low sRAGE concentrations, and certain RAGE polymorphisms are associated with rheumatic diseases and cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lory Sthephany Rochin-Hernandez, Lory Jhenifer Rochin-Hernandez, Luis Bernardo Flores-Cotera
Summary: Endophytes, microorganisms that live in plants, have the potential to produce bioactive compounds, including anti-aging compounds. This study discusses the importance and challenges of using endophytes as a source of anti-aging compounds, focusing on 26 plant compounds and derivatives that have been reported as endophytic metabolites.
Article
Biochemistry & Molecular Biology
Fengmao An, Ruyi Zhao, Xinran Xuan, Tianqi Xuan, Guowei Zhang, Chengxi Wei
Summary: Growing evidence suggests that calycosin may have therapeutic effects on Alzheimer's disease, especially in Alzheimer's disease related to diabetes. Experimental results show that calycosin can promote neuronal survival, improve learning and memory abilities, down-regulate certain disease-related protein activities, reduce the production of amyloid protein, and repair mitochondrial dysfunction.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Bednarska, Izabela Fecka
Summary: The unfermented rooibos extract showed a higher ability to trap methylglyoxal and glyoxal and inhibit the formation of advanced glycation end products (AGEs) than the fermented rooibos extract, mainly due to its higher content of dihydrochalcones. Compounds found in rooibos tea, such as aspalathin and vitexin, were able to trap methylglyoxal and glyoxal, and isovitexin showed the strongest inhibition of AGE formation. In addition to its other health benefits, rooibos tea could potentially be used as an alpha-dicarbonyl trapping agent and AGE inhibitor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
V. Prakash Reddy, Puspa Aryal, Emmanuel K. Darkwah
Summary: Advanced glycation end products (AGEs), formed through nonenzymatic reactions, play a significant role in the pathogenesis of various diseases, including diabetes, atherosclerosis, and Alzheimer's disease. The interactions of AGEs with their receptors (RAGE) and Maillard reactions in gut microbiota also contribute to disease progression.
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Article
Cell Biology
Cristian Arriagada-Petersen, Paula Fernandez, Maira Gomez, Natalia Ravello, Ivan Palomo, Eduardo Fuentes, Felipe Avila
Summary: This study suggests that AGEs formed with MG-Lys induce a higher activation and aggregation of platelets when compared to those formed from Gly-Lys. The effects of AGEs on platelet activation and aggregation vary depending on the concentrations and the type of AGEs generated.
Article
Chemistry, Applied
Yin He, Zhijun Yang, Jingwen Pi, Tiange Cai, Ying Xia, Xiangyu Cao, Jianli Liu
Summary: This study found that EGCG can attenuate MGO-induced nerve damage by regulating MAPK and downstream pathways, as well as inhibiting the formation of AGEs.
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)