Review
Chemistry, Medicinal
Milad Iranshahy, Behjat Javadi, Amirhossein Sahebkar
Summary: This study investigates the potential of Persian Medicine-recommended foods in preventing and treating CNS-related tremors, specifically Parkinson's disease. The findings suggest that certain plants and substances, such as garlic, cabbage, chickpea seed, cinnamon, saffron, black cumin, black pepper, pistachio, and resveratrol, possess beneficial properties in alleviating and preventing the progression of Parkinson's disease through their antioxidant and anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2022)
Review
Clinical Neurology
Kaitlyn M. L. Cramb, Dayne Beccano-Kelly, Stephanie J. Cragg, Richard Wade-Martins
Summary: Cramb et al. provide a review of evidence suggesting dopamine release deficits occur prior to neurodegeneration in Parkinson's disease. They also highlight the need for further investigation in understanding the mechanisms behind these deficits.
Article
Chemistry, Multidisciplinary
Javier Garcia-Pardo, Fernando Novio, Fabiana Nador, Ivana Cavaliere, Salvio Suarez-Garcia, Silvia Lope-Piedrafita, Ana Paula Candiota, Jordi Romero-Gimenez, Beatriz Rodriguez-Galvan, Jordi Bove, Miquel Vila, Julia Lorenzo, Daniel Ruiz-Molina
Summary: This study demonstrates the synthesis of neuromelanin bioinspired polymeric nanoparticles for encapsulating DA with high loading efficiency. In vitro, the DA-NCPs showed lower toxicity and enhanced uptake by dopaminergic cells compared to free DA. In vivo, nasal administration of DA-NCPs increased striatal DA levels and reduced apomorphine-induced rotations, highlighting the potential of nanostructured DA for DA-replacement therapy.
Article
Biochemistry & Molecular Biology
Sarah Thomas Broome, Alessandro Castorina
Summary: The study shows that buspirone has neuroprotective effects in models of Parkinson's disease, preventing damage to the central nervous system and improving mitochondrial function and antioxidant activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Jillian M. Doyle, Roger P. Croll
Summary: Zebrafish has been widely used as a model for various human diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases. This review critically evaluates the available models of Parkinson's Disease in zebrafish and compares them with other animal models. Zebrafish has unique advantages, such as a wide range of behavioral assays and high-throughput screens, as well as the ability for genetic manipulation and in vivo visualization. This makes zebrafish a versatile model for investigating disease states.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhi Dong Zhou, Wuan Ting Saw, Patrick Ghim Hoe Ho, Zhi Wei Zhang, Li Zeng, Ya Yin Chang, Alfred Xu Yang Sun, Dong Rui Ma, Hong Yan Wang, Lei Zhou, Kah Leong Lim, Eng-King Tan
Summary: This study found that the TH-DA pathway plays a critical role in the pathogenesis of Parkinson's disease. LRRK2 and PINK1 have opposing effects on the TH-DA pathway, and the balance between them affects the survival of DA neurons. Mutations in LRRK2 or PINK1 can disrupt this balance, leading to the demise of DA neurons.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Nutrition & Dietetics
Julienne Haas, Daniela Berg, Anja Bosy-Westphal, Eva Schaeffer
Summary: Studies show that patients with Parkinson's disease have a strong craving for sweets and consume more high-sugar food. This high-sugar intake may increase insulin concentration, which can positively affect dopamine concentration in the brain and act as self-medication to compensate for dopamine deficiency. However, it may also lead to insulin resistance and diabetes, which are discussed as causes for progressive neurodegeneration in Parkinson's disease.
Article
Clinical Neurology
Jiaxin Li, Minhan Yi, Binbin Li, Shujuan Yin, Ying Zhang, Zini Huang, Li Shu, Yuan Zhang
Summary: This study conducted a systematic meta-analysis of variants related to neurodegenerative genes and their association with the risk of Parkinson's disease (PD). The results showed that several variants were statistically associated with PD risk, which may contribute to a deeper understanding of PD pathogenesis and improvement of clinical treatment strategies.
NEUROLOGICAL SCIENCES
(2022)
Editorial Material
Multidisciplinary Sciences
Zak Doric, Ken Nakamura
Summary: By disrupting mitochondria in vulnerable neuronal cells, mice provide a new model of Parkinson's disease that challenges long-held ideas about the disease's motor symptoms.
Review
Neurosciences
Zhi Dong Zhou, Ling Xiao Yi, Dennis Qing Wang, Tit Meng Lim, Eng King Tan
Summary: A pathological feature of Parkinson's disease is the progressive loss of dopaminergic neurons and decreased dopamine content in the brain. Dopamine interacts with environmental and genetic factors to contribute to the disease. Abnormalities in dopamine synthesis, storage, transportation, and metabolism promote neurodegeneration in Parkinson's disease. The unstable nature of dopamine leads to the production of reactive and toxic by-products. This summary highlights recent discoveries on the role of dopamine in Parkinson's disease and discusses potential strategies for protection and treatment.
TRANSLATIONAL NEURODEGENERATION
(2023)
Review
Biochemistry & Molecular Biology
Sandro Huenchuguala, Juan Segura-Aguilar
Summary: Iron plays a fundamental role in various aspects of human life, but an imbalance in iron levels can lead to certain pathologies. Maintaining iron homeostasis is crucial in preventing these pathologies. While there is evidence suggesting iron's involvement in the degenerative process of Parkinson's disease, clinical studies have not shown positive effects of iron chelators in treating the disease.
Review
Medical Laboratory Technology
Saad Latif, Muhammad Jahangeer, Dure Maknoon Razia, Mehvish Ashiq, Abdul Ghaffar, Muhammad Akram, Aicha El Allam, Abdelhakim Bouyahya, Larisa Garipova, Mohammad Ali Shariati, Muthu Thiruvengadam, Mohammad Azam Ansari
Summary: This article briefly reviews the synthesis pathway of dopamine in Parkinson's disease, its distribution and receptor family, as well as the compounds formed during the oxidation process. By discussing the role of dopamine and its mechanism in Parkinson's disease, it reveals its dual effects in neurotoxicity and neuroprotection.
CLINICA CHIMICA ACTA
(2021)
Review
Pharmacology & Pharmacy
Thomas Mueller
Summary: Certain mutations of the abundant leucine-rich repeat kinase 2 gene contribute to the onset of inherited and sporadic forms of idiopathic Parkinson's disease. Inhibition of leucine-rich repeat kinase 2 activity was efficacious, safe, and well tolerated in experimental investigations and in the still ongoing clinical study program. Approval of this therapeutic concept after future positive clinical study outcomes is the introduction of personalized medicine based on molecular mechanisms and targets in Parkinson's disease. Beneficial modification of progression is the most unmet need for the therapy of patients with Parkinson's disease.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Biochemical Research Methods
Mukuo Wang, Shujing Hou, Yu Wei, Dongmei Li, Jianping Lin
Summary: Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system. Dual adenosine A(1)/A(2A) receptor antagonists provide a possible effective therapy that can simultaneously solve motor symptoms and nonmotor symptoms in the medical treatment of PD. In this study, a multistage virtual screening approach involving deep learning, pharmacophore models, and molecular docking methods identified two 1,2,4-triazole derivatives as dual adenosine A(1) and A(2A) receptor antagonists. The results of molecular dynamics (MD) simulations showed strong binding interactions between the adenosine A(1)/A(2A) receptors and the compounds.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Neurosciences
Rachel M. Wise, Annika Wagener, Urban M. Fietzek, Thomas Klopstock, Eugene V. Mosharov, Fabio A. Zucca, David Sulzer, Luigi Zecca, Lena F. Burbulla
Summary: The involvement of dopamine metabolism, alpha-synuclein pathology, and iron homeostasis has been implicated in the unique vulnerability of substantia nigra dopaminergic neurons. However, the mechanisms contributing to disease progression and resulting in dopaminergic neuron loss are still not completely understood. The disrupted interplay of dopamine, alpha-synuclein, and iron pathways may synergize to promote pathology and drive vulnerability to disease states.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Peter Hornyak, Trevor Askwith, Sarah Walker, Emilia Komulainen, Michael Paradowski, Lewis E. Pennicott, Edward J. Bartlett, Nigel C. Brissett, Ali Raoof, Mandy Watson, Allan M. Jordan, Donald J. Ogilvie, Simon E. Ward, John R. Atack, Laurence H. Pearl, Keith W. Caldecott, Antony W. Oliver
BIOCHEMICAL JOURNAL
(2016)
Article
Biochemical Research Methods
Jan R. Detrez, Jean-Marie Vanderwinden, Michael Barbier, Marlies Verschuuren, Rony Nuydens, Xavier Langlois, Jean-Pierre Timmermans, Winnok H. De Vos
Article
Chemistry, Multidisciplinary
Tim Gaekens, Michel Guillaume, Herman Borghys, Loeckie L. De Zwart, Ronald de Vries, Roger C. A. Embrechts, An Vermeulen, Anton A. H. P. Megens, Josee E. Leysen, Piet Herdewijn, Pieter P. Annaert, John R. Atack
JOURNAL OF CONTROLLED RELEASE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dieter Ory, Sofie Celen, Rik Gijsbers, Chris Van Den Haute, Andrey Postnov, Michel Koole, Caroline Vandeputte, Jose-Ignacio Andres, Jesus Alcazar, Med De Angelis, Xavier Langlois, Anindya Bhattacharya, Mark Schmidt, Michael A. Letavic, Wim Vanduffel, Koen Van Laere, Alfons Verbruggen, Zeger Debyser, Guy Bormans
JOURNAL OF NUCLEAR MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gil Leurquin-Sterk, Sofie Celen, Koen Van Laere, Michel Koole, Guy Bormans, Xavier Langlois, Anne Van Hecken, Paula te Riele, Jesus Alcazar, Alfons Verbruggen, Jan de Hoon, Jose-Ignacio Andres, Mark E. Schmidt
JOURNAL OF NUCLEAR MEDICINE
(2017)
Article
Neurosciences
A. Ahnaou, P. de Boer, H. Lavreysen, H. Huysmans, V. Sinha, L. Raeymaekers, T. Van De Casteele, J. M. Cid, L. Van Nueten, G. J. Macdonald, J. A. Kemp, W. H. I. M. Drinkenburg
Article
Biochemical Research Methods
Steven Deleye, Ann-Marie Waldron, Jill C. Richardson, Mark Schmidt, Xavier Langlois, Sigrid Stroobants, Steven Staelens
Article
Chemistry, Medicinal
Ryan A. West, Oran G. O'Doherty, Trevor Askwith, John Atack, Paul Beswick, Jamie Laverick, Michael Paradowski, Lewis E. Pennicott, Srinivasa P. S. Rao, Gareth Williams, Simon E. Ward
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Biochemical Research Methods
Lucas Kraft, S. Mark Roe, Raj Gill, John R. Atack
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2018)
Article
Biochemical Research Methods
James W. Noble, Rehab Almalki, S. Mark Roe, Armin Wagner, Ramona Duman, John R. Atack
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2018)
Article
Biochemical Research Methods
Gareth D. Fenn, Helen Waller-Evans, John R. Atack, Benjamin D. Bax
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
(2020)
Article
Biology
Chloe R. Koulouris, Sian E. Gardiner, Tessa K. Harris, Karen T. Elvers, S. Mark Roe, Jason A. Gillespie, Simon E. Ward, Olivera Grubisha, Robert A. Nicholls, John R. Atack, Benjamin D. Bax
Summary: Human serine racemase (hSR) catalyzes the conversion of L-serine to D-serine and plays a role in the activation of NMDA receptors. The positioning of Tyr121 appears to be crucial in regulating the activity of hSR.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
James W. Noble, John R. Atack
Summary: This study investigates the interaction between Calbindin-D28k and IMPase, and reveals that the fusion proteins have higher activity and a different shape compared to the previous model. These findings provide important insights into this protein-protein interaction.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Lucas Kraft, Louise C. Serpell, John R. Atack
Article
Chemistry, Applied
Raysa Khan, Sarote Boonseng, Paul D. Kemmitt, Robert Felix, Simon J. Coles, Graham J. Tizzard, Gareth Williams, Olivia Simmonds, Jessica-Lily Harvey, John Atack, Hazel Cox, John Spencer
ADVANCED SYNTHESIS & CATALYSIS
(2017)