Article
Behavioral Sciences
Nicholas S. Race, Katharine D. Andrews, Elizabeth A. Lungwitz, Sasha M. Vega Alvarez, Timothy R. Warner, Glen Acosta, Jiayue Cao, Kun-han Lu, Zhongming Liu, Amy D. Dietrich, Sreeparna Majumdar, Anantha Shekhar, William A. Truitt, Riyi Shi
Summary: TBI is associated with increased risk for mental health disorders, and deficits in psychosocial processing may contribute to post-TBI mental health issues. A pre-clinical investigation using rats found that a single mild blast TBI induced impairment of psychosocial processing in the absence of other confounding factors, and this impairment may be related to acute upregulations of an oxidative stress metabolite.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Caroline A. Browne, Hildegard A. Wulf, Moriah L. Jacobson, Mario G. Oyola, T. John Wu, Irwin Lucki
Summary: Neurobehavioral deficits can emerge in patients after a mild traumatic brain injury (TBI) and nearly half of them may experience these deficits for months. Ketamine, commonly used as an anesthetic/analgesic, may have beneficial effects on patients with a history of TBI, but caution should be exercised due to potential impairing effects. Studies on mice showed that sensitivity to ketamine increased in mice after TBI, suggesting caution should be taken when using ketamine in TBI patients.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Laura M. Anderson, Sridhar Samineni, Donna M. Wilder, Marisela Lara, Ondine Eken, Rodrigo Urioste, Joseph B. Long, Peethambaran Arun
Summary: The study found that meloxicam and buprenorphine demonstrated neuroprotective effects in a rat bTBI model, but also had negative impacts such as slowing recovery and causing short-term memory deficits. These results suggest that these pain relieving medications may not be ideal for pre-clinical studies evaluating neurobehavioral responses after TBI due to their varied effects on neurobehavioral functions.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Scott T. Miller, Candice F. Cooper, Paul Elsbernd, Joseph Kerwin, Ricardo Mejia-Alvarez, Adam M. Willis
Summary: Blast traumatic brain injury is a common occurrence in modern military conflicts and may be caused by damage to intracranial mechanical interfaces. Both neuropathological and clinical findings suggest that injury occurs at material interfaces within the brain tissue, which could be key in understanding how blast overpressures lead to intracranial damage.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Rebecca R. Schmitt, Kathiravan Kaliyappan, Vijaya Prakash Krishnan Muthaiah, Tracey A. Ignatowski, Paras N. Prasad, Supriya D. Mahajan
Summary: Disruption of the blood-brain barrier is crucial in the progression of traumatic brain injury, and further research into the mechanism is necessary for understanding TBI pathophysiology. Studying gene expression changes in HBMVEC can help elucidate the interaction between BBB pathophysiology and TBI.
Article
Biotechnology & Applied Microbiology
Dhananjay Radhakrishnan Subramaniam, Ginu Unnikrishnan, Aravind Sundaramurthy, Jose E. Rubio, Vivek Bhaskar Kote, Jaques Reifman
Summary: Studies on the biomechanical responses of the human brain to blast waves have highlighted the importance of including detailed information such as brain-surface convolutions, major cerebral veins, and non-linear brain-tissue properties for improving model accuracy. Inclusion of a more detailed network of cerebral veins and arteries can enhance model-predicted biomechanical responses and help identify correlates of blast-induced brain injury. The detailed cerebral vasculature model redistributed brain-tissue strains and highlighted the importance of including a detailed cerebral vessel network in human-head FE models to more comprehensively account for the biomechanical responses induced by blast exposure.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fernanda Guilhaume-Correa, Alicia M. Pickrell, Pamela J. VandeVord
Summary: Mild blast-induced traumatic brain injury (bTBI) is a concern for military personnel exposed to explosive blast waves. Astrcoyte-specific mitochondrial dynamics in bTBI have not been well-characterized. Mitochondrial dynamics, including fission and fusion events, play a role in mitochondrial function. Astrocytic mitochondria are important for brain metabolism and protection. Injury insults can increase mitochondrial fragmentation, which can have negative consequences. A study explored the role of DRP1 in astrocytic mitochondrial dynamics in bTBI models and observed differential remodeling of the mitochondrial network and reactive astrocyte phenotype transition. This discovery can lead to new therapeutic targets to prevent secondary injury cascade after blast injury involving mitochondrial dysfunction.
Article
Neurosciences
Yang Li, Kaijun Liu, Chang Li, Yu Guo, Jingqin Fang, Haipeng Tong, Yi Tang, Junfeng Zhang, Jinju Sun, Fangyang Jiao, Qianhui Zhang, Rongbing Jin, Kunlin Xiong, Xiao Chen
Summary: Blast-induced mild traumatic brain injury patients often experience persistent neurological dysfunction without abnormal findings on conventional MRI. Advanced imaging techniques such as F-18-FDG PET and MR spectroscopy are crucial for detecting and understanding the pathophysiology of blast-induced mTBI. Combining F-18-FDG PET with MR spectroscopy can effectively evaluate acute and subacute metabolic cerebral alterations caused by this type of TBI.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Jared A. Rifkin, Taotao Wu, Adam C. Rayfield, Erin D. Anderson, Matthew B. Panzer, David F. Meaney
Summary: Research on data from the Human Connectome Project (HCP) reveals similar brain architecture groups in both men and women, with some architectures being more vulnerable to traumatic brain injuries (TBI).
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Koji Yamamura, Nobuaki Kiriu, Satoshi Tomura, Satoko Kawauchi, Kaoru Murakami, Shunichi Sato, Daizoh Saitoh, Hidetaka Yokoe
Summary: This study investigated the mechanism of acute fatalities associated with blast injuries using laser-induced shock waves. The results showed that mice with upper neck exposure, without damage elsewhere, had a higher mortality rate, and their respiratory function was severely affected. Protecting the upper neck region may help reduce the mortality rate associated with blast injuries.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Sarah Simmons, Ludovic D. Langlois, Mario G. Oyola, Shawn Gouty, T. John Wu, Fereshteh S. Nugent
Summary: Blast-induced mild traumatic brain injury may dysregulate hypothalamic corticotropin-releasing factor (CRF) neurons and GABAergic synaptic function, contributing to stress psychopathology associated with blast injury.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Article
Neuroimaging
David F. Tate, Emily L. Dennis, John T. Adams, Maheen M. Adamson, Heather G. Belanger, Erin D. Bigler, Heather C. Bouchard, Alexandra L. Clark, Lisa M. Delano-Wood, Seth G. Disner, Blessen C. Eapen, Carol E. Franz, Elbert Geuze, Naomi J. Goodrich-Hunsaker, Kihwan Han, Jasmeet P. Hayes, Sidney R. Hinds, Cooper B. Hodges, Elizabeth S. Hovenden, Andrei Irimia, Kimbra Kenney, Inga K. Koerte, William S. Kremen, Harvey S. Levin, Hannah M. Lindsey, Rajendra A. Morey, Mary R. Newsome, John Ollinger, Mary Jo Pugh, Randall S. Scheibel, Martha E. Shenton, Danielle R. Sullivan, Brian A. Taylor, Maya Troyanskaya, Carmen Velez, Benjamin S. C. Wade, Xin Wang, Ashley L. Ware, Ross Zafonte, Paul M. Thompson, Elisabeth A. Wilde
Summary: Traumatic brain injury (TBI) is common in military and civilian populations, leading to a range of clinical, cognitive, behavioral, mood, and neuroimaging changes. The inconsistent presentation of TBI poses challenges in establishing biological and imaging markers, although big data approaches offer opportunities to better understand its impact in military populations.
BRAIN IMAGING AND BEHAVIOR
(2021)
Review
Neurosciences
Lucy P. Evans, Ariel M. Roghair, Noah J. Gilkes, Alexander G. Bassuk
Summary: Studies have found that bTBI can cause persistent physical, cognitive, and psychological disorders, with current therapies not effectively alleviating these issues. The complexity of studying visual dysfunction after blast injury is complicated by variables such as injury location, severity, and head and body shielding. Certain pharmacologic treatments have been shown to alleviate visual deficits in post-bTBI animal models.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Jie Ma, Junrui Wang, Kaiwen Deng, Yu Gao, Wenjing Xiao, Jun Hou, Changqing Jiang, Jing Li, Botao Yu
Summary: The study revealed that MaxiK channel might be involved in the process of neuroinflammation of bTBI. Paxilline could depress neuro-inflammation response and alleviate brain injury by blocking MaxiK channel and subsequently inhibiting NLRP3 inflammasome activation.
Article
Biochemistry & Molecular Biology
Melike Can, Tugce Senguel, Secil Akyildiz Demir, Orhan K. Inci, Hande Basirli, Volkan Seyrantepe
Summary: This study explored the secondary accumulation of lipids in the brain of Hexa-/-Neu3-/- mice, a mice model for Tay-Sachs disease. The results showed alterations in lipid levels and neuropathological changes, such as demyelination and axonal degeneration. Understanding of brain-specific lipid alterations contributes to evaluating the effectiveness of treatments in future studies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemical Research Methods
Helene Cazier, Carole Malgorn, Nathalie Fresneau, Dominique Georgin, Antoine Sallustrau, Celine Chollet, Jean-Claude Tabet, Stephan Campidelli, Mathieu Pinault, Martine Mayne, Frederic Taran, Vincent Dive, Christophe Junot, Francois Fenaille, Benoit Colsch
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2020)
Article
Endocrinology & Metabolism
Nathalie Poupin, Florence Vinson, Arthur Moreau, Aurelie Batut, Maxime Chazalviel, Benoit Colsch, Laetitia Fouillen, Sarah Guez, Spiro Khoury, Jessica Dalloux-Chioccioli, Anthony Tournadre, Pauline Le Faouder, Corinne Pouyet, Pierre Van Delft, Fanny Viars, Justine Bertrand-Michel, Fabien Jourdan
Article
Clinical Neurology
Stephane Fourcade, Leire Goicoechea, Janani Parameswaran, Agatha Schluter, Nathalie Launay, Montserrat Ruiz, Alexandre Seyer, Benoit Colsch, Noel Ylagan Calingasan, Isidre Ferrer, M. Flint Beal, Frederic Sedel, Aurora Pujol
Article
Clinical Neurology
Carey D. Balaban, Mikhaylo Szczupak, Alexander Kiderman, Bonnie E. Levin, Michael E. Hoffer
FRONTIERS IN NEUROLOGY
(2020)
Article
Neurosciences
Andrew A. McCall, Derek M. Miller, Carey D. Balaban
Summary: The study demonstrates that vestibular nucleus neurons in conscious cats respond well to combined vestibular and hindlimb proprioceptive stimulation, fitting a simple additive model. This suggests that neurons in this region play a key role in adjusting vestibulospinal outflow in response to limb state.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Takaki Inui, Michael Hoffer, Carey D. Balaban
Summary: This study examines regional changes in immunoreactive MMP2 in the rat brain after blast overpressure exposure, showing differences in MMP2 expression in different brain regions, suggesting that local MMP2 responses may serve as biomarkers for locally regulated responses to brain injury.
Article
Gastroenterology & Hepatology
Ingrid W. Zhang, Anna Curto, Cristina Lopez-Vicario, Mireia Casulleras, Marta Duran-Guell, Roger Flores-Costa, Benoit Colsch, Ferran Aguilar, Ana M. Aransay, Juan Jose Lozano, Maria Hernandez-Tejero, David Toapanta, Javier Fernandez, Vicente Arroyo, Joan Claria
Summary: The study revealed severe mitochondrial dysfunction in leukocytes of patients with acute decompensated cirrhosis and ACLF, suggesting that mitochondrial abnormalities in body tissues may be a consequence of inadequate cell energy output.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Joan Claria, Anna Curto, Richard Moreau, Benoit Colsch, Cristina Lopez-Vicario, Juan Jose Lozano, Ferran Aguilar, Florence A. Castelli, Francois Fenaille, Christophe Junot, Ingrid Zhang, Maria Vinaixa, Oscar Yanes, Paolo Caraceni, Jonel Trebicka, Javier Fernandez, Paolo Angeli, Rajiv Jalan, Vicente Arroyo
Summary: This study focused on blood lipidomics in cirrhosis patients, revealing a generalized suppression of lipids in circulation. Specific lipid fingerprints were identified for distinguishing AD and ACLF, with liver dysfunction and infections playing key roles in their dynamics. Moreover, blood lysophosphatidylcholine levels increased in patients after albumin therapy.
JOURNAL OF HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Blandine Comte, Stephanie Monnerie, Marion Brandolini-Bunlon, Cecile Canlet, Florence Castelli, Emeline Chu-Van, Benoit Colsch, Francois Fenaille, Charlotte Joly, Fabien Jourdan, Natacha Lenuzza, Bernard Lyan, Jean-Francois Martin, Carole Migne, Jose A. Morais, Melanie Petera, Nathalie Poupin, Florence Vinson, Etienne Thevenot, Christophe Junot, Pierrette Gaudreau, Estelle Pujos-Guillot
Summary: The study used a multiplatform metabolomics and lipidomics untargeted strategy to characterize metabolic perturbations in MetS, identifying significant changes and defining a comprehensive MetS signature for future clinical applications. This approach provides insights into the systemic alterations of metabolism in MetS, contributing to better diagnostic methods for the syndrome.
Article
Cell Biology
Thais Hautbergue, Fabrice Antigny, Angele Boet, Francois Haddad, Bastien Masson, Melanie Lambert, Amelie Delaporte, Jean-Baptiste Menager, Laurent Savale, Jerome Le Pavec, Elie Fadel, Marc Humbert, Christophe Junot, Francois Fenaille, Benoit Colsch, Olaf Mercier
Summary: This study aimed to characterize metabolic alterations associated with right ventricular remodeling in pulmonary hypertension by examining rat models exposed to chronic hypoxia or monocrotaline. The results showed that changes in arginine, pyrimidine, purine, and tryptophan metabolic pathways were correlated with RV function in the CH-PH model, providing potential biomarkers for early detection of RV failure.
Article
Biochemical Research Methods
Juliette Pelle, Florence A. Castelli, Marika Rudler, Imen Alioua, Benoit Colsch, Francois Fenaille, Christophe Junot, Dominique Thabut, Nicolas Weiss
Summary: Metabolomics is a technique used to study biological components involved in metabolic pathways below 1000 Daltons, which has shown potential in revealing pathophysiological insights, identifying new biomarkers, and predicting treatment response or outcome prognosis in hepatic encephalopathy.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Anais C. George, Isabelle Schmitz-Afonso, Vincent Marie, Benoit Colsch, Francois Fenaille, Carlos Afonso, Corinne Loutelier-Bourhis
Summary: Collision cross sections (CCS) are important molecular descriptors in metabolomics and lipidomics analyses. Ion mobility spectrometry (IMS) can determine CCS, but different techniques require calibration and lead to varying results. This study evaluates 11 different CCS calibrants and proposes a method to recalibrate CCS values using Tune Mix solution for more accurate and comparable results.
ANALYTICA CHIMICA ACTA
(2022)
Article
Oncology
Marie Sabatier, Rudy Birsen, Laura Lauture, Sarah Mouche, Paolo Angelino, Jonas Dehairs, Ismael Boussaid, Mael Heiblig, Emeline Boet, Ambrine Sahal, Estelle Saland, Juliana C. Santos, Marc Armengol, Miranda Fernandez-Serrano, Thomas Farge, Guillaume Cognet, Federico Simonetta, Corentin Pignon, Antoine Graffeuil, Celine Mazzotti, Herve Avet-Loiseau, Oceane Delos, Justine Bertrand-Michel, Amelie Chedru, Vilma Dembitz, Paolo Gallipoli, Natasha S. Anstee, Sun Loo, Andrew H. Wei, Martin Carroll, Armelle Goubard, Remy Castellano, Yves Collette, Francois Vergez, Veronique Mansat-De Mas, Sarah Bertoli, Suzanne Tavitian, Muriel Picard, Christian Recher, Nathalie Bourges-Abella, Fanny Granat, Olivier Kosmider, Pierre Sujobert, Benoit Colsch, Carine Joffre, Lucille Stuani, Johannes V. Swinnen, Herve Guillou, Gael Roue, Nawad Hakim, Anne S. Dejean, Petros Tsantoulis, Clement Larrue, Didier Bouscary, Jerome Tamburini, Jean-Emmanuel Sarry
Summary: Although the role of CCAAT-enhancer binding protein α (C/EBPα) in cancer cell and metabolic homeostasis is largely unknown, this study reveals its coordination with FLT3 in lipid anabolism and its regulation of fatty acid biosynthesis and desaturation. Furthermore, FLT3 or C/EBPα inactivation decreases monounsaturated fatty acid incorporation and renders FLT3-mutant AML cells vulnerable to ferroptosis. This finding suggests a promising therapeutic potential for targeting FLT3-mutant AML cells.
Article
Chemistry, Multidisciplinary
Helene Cazier, Carole Malgorn, Dominique Georgin, Nathalie Fresneau, Fabrice Beau, Kostas Kostarelos, Cyrill Bussy, Stephane Campidelli, Mathieu Pinault, Martine Mayne-L'Hermite, Frederic Taran, Christophe Junot, Francois Fenaille, Antoine Sallustrau, Benoit Colsch
Summary: Research on graphene based nanomaterials has expanded in recent years due to their unique properties and potential socio-economic impact. This study proposes a novel approach combining radioimaging and mass spectrometry imaging for detecting Graphene Oxide (GO) labeled with carbon-14 in mice. The results demonstrate the advantages of this correlative imaging technique for the pre-clinical development of graphene-based biomedical applications.
Review
Otorhinolaryngology
Jennifer Coto, Carmen L. Alvarez, Ivette Cejas, Brett M. Colbert, Bonnie E. Levin, Joshua Huppert, Tatjana Rundek, Carey Balaban, Susan H. Blanton, David J. Lee, David Loewenstein, Michael Hoffer, Xue Zhong Liu
Summary: The study emphasizes the importance of examining the individual contributions of factors such as balance, vision, and cognition in age-related vestibular loss. While the relationship between the vestibular and visual systems has been well studied, little is known about the association of the peripheral vestibular system with neurodegenerative disorders. Emerging research suggests that the vestibular system can be a key factor in examining brain function beyond balance, into areas such as cognition and psychological functioning.
JOURNAL OF OTOLOGY
(2021)