Article
Biochemistry & Molecular Biology
Helena Laronha, Ines Carpinteiro, Jaime Portugal, Ana Azul, Mario Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona, Jorge Caldeira
Summary: A new class of MMP inhibitors has been discovered, which can be co-polymerized with other vinyl compounds in commercial dental resins, limiting release and potential toxicity, and increasing safety. These inhibitors show unique properties towards various MMPs and did not significantly decrease cell viability at high concentrations.
Review
Chemistry, Multidisciplinary
Mayland Chang, Trung T. Nguyen
Summary: Diabetic foot ulcers (DFUs) are chronic wounds that affect 30% of diabetic patients, with dysregulation of the normal wound healing process. Infection in DFUs increases inflammation and delays wound healing. Selective inhibition of MMP-9 may be a promising strategy for treatment of DFUs.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Cell Biology
Yao Tong, Zhuang Yu, Zhixia Chen, Renlingzi Zhang, Xibing Ding, Xiaohu Yang, Xiaoyin Niu, Mengzhu Li, Lingling Zhang, Timothy R. Billiar, Bruce R. Pitt, Quan Li
Summary: Imbalance of macrophage polarization is crucial in acute lung injury (ALI), with MMP-9 playing a key role in this process. SQV maintains the M2 phenotype by inhibiting MMP-9, alleviating ALI. Monitoring levels of MMP-9 may serve as a biomarker for sepsis, and SQV can suppress LPS-mediated M1 phenotype.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Zhenzhou Chen, Dennis Chuang, Shanyan Chen, Qiwei He, Brittany N. Tomlison, Jiankun Cui, Zezong Gu
Summary: This study investigated the effects of four commonly used fixatives (ethanol, acetone, ZBF, and PFA) on gelatinase activity in mouse brain tissue. The results showed that ethanol, acetone, ZBF, and short-term PFA fixation did not inhibit gelatinase activity. Effective protein extraction methods were identified using 8 M urea + 4% CHAPS and 2% SDS while retaining gelatinase activity.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Kang Fu, Xueyao Zheng, Yuhan Chen, Liuying Wu, Zhiming Yang, Xu Chen, Wei Song
Summary: Diabetic foot ulcers (DFUs) are serious complications of diabetes mellitus, characterized by tissue destruction in the foot. Matrix metalloproteinases (MMPs) play crucial roles in the pathogenesis and wound healing process of DFUs. Overexpression of MMPs in DFUs can result in excessive tissue degradation and impaired wound healing. Regulation of MMP levels may facilitate wound healing in DFUs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Lukasz Charzewski, Krystiana A. Krzysko, Bogdan Lesyng
Summary: MMP-9 is an enzyme that plays important physiological functions but is also involved in pathological processes like cancer invasion, metastasis, and angiogenesis. It may be related to the cytokine storm in COVID-19 and the molecular mechanisms of lung fibrosis. Understanding the interactions between MMP-9 and its natural inhibitor TIMP-1 is crucial for elucidating its regulatory processes.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Rohit Siddhartha, Minal Garg
Summary: MMPs are a group of enzymes that play a crucial role in degrading proteins in the extracellular matrix and regulating cell signaling. Dysregulation of MMPs can lead to serious pathological conditions such as inflammation, uncontrolled cell growth, and cancer metastasis. Understanding the functions of MMPs has potential implications for cancer diagnosis, prognosis, and therapy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Fisheries
Zhimeng Lv, Guanghui Han, Chenghua Li
Summary: The TIMP1 gene plays a crucial role in inflammatory diseases in vertebrates, responding to bacterial challenge and LPS exposure. AjTIMP1 is expressed in all tissues, with the highest levels in the body wall. Imbalance in AjMMP1/AjTIMP1 ratio was observed in skin ulceration syndrome patients, leading to an inflammatory response with ROS formation and collagen degradation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aneta Choreziak-Michalak, Dawid Szpecht, Anna Chmielarz-Czarnocinska, Agnieszka Seremak-Mrozikiewicz, Krzysztof Drews, Grazyna Kurzawinska, Ewa Strauss, Anna Gotz-Wieckowska
Summary: This study investigates the relationship between genetic variations in matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) and the development of retinopathy of prematurity (ROP) in the Polish population. The results suggest that certain genetic variants, including the MMP-1 rs179975 1G deletion allele and TIMP-1 rs4898C allele, are associated with an increased risk of ROP. The study also identifies interactions between multiple genetic loci that impact the risk of ROP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Anna Surowka, Aleksandra Wilk, Kamila Szumilas, Karolina Kedzierska-Kapuza
Summary: This study focuses on the role of MMPs in the pathogenesis of vascular damage and the influence of immunosuppressive treatment. Understanding the effects of immunosuppressive drugs on organ and tissue pathology and their impact on MMP activity in vessel walls is crucial for transplant recipients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Chun-Yan Wan, Lei Li, Ling-Shuang Liu, Chun-Miao Jiang, Hong-Zhe Zhang, Jian-Xun Wang
Summary: The study investigated the relationship between MMPs and TIMPs during the development of apical periodontitis in mice. Results showed that the expression levels of MMPs and TIMPs increased with periapical inflammation progression, with variations in expression levels during acute and chronic stages.
JOURNAL OF ENDODONTICS
(2021)
Article
Medicine, Research & Experimental
Craig N. Morrell, Doran Mix, Anu Aggarwal, Rohan Bhandari, Matthew Godwin, Phillip Owens, Sean P. Lyden, Adam Doyle, Krystin Krauel, Matthew T. Rondina, Amy Mohan, Charles J. Lowenstein, Sharon Shim, Shaun Stauffer, Vara Prasad Josyula, Sara K. Ture, David Yule, Larry E. Wagner, John M. Ashton, Ayman Elbadawi, Scott J. Cameron
Summary: Biomechanical platelet activation may be a potential mechanism behind resistance to antiplatelet medication. A study on patients with abdominal aortic aneurysms (AAA) found that activation of olfactory receptor pathway is associated with AAA progression. A molecule activating platelet olfactory receptor was identified and shown to inhibit platelet activation and AAA growth.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Shriefa Almutairi, Hanin Moh'd Kalloush, Nour A. Manoon, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins in the extracellular matrix (ECM). They play a role in various biological processes and have become attractive therapeutic targets for cancer treatment.
Article
Pharmacology & Pharmacy
Sabrina Giofre, Antonio Renda, Silvia Sesana, Beatrice Formicola, Barbara Vergani, Biagio Eugenio Leone, Vanna Denti, Giuseppe Paglia, Serena Groppuso, Valentina Romeo, Luca Muzio, Andrea Balboni, Andrea Menegon, Antonia Antoniou, Arianna Amenta, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
Summary: Dual functionalized liposomes with modified peptides and MMP-sensitive moieties have the ability to cross BBB and release drugs in MMP-rich microenvironment. These liposomes display good biocompatibility and efficiently release encapsulated fluorescent dyes.
Article
Engineering, Biomedical
Mee-Hae Kim, Shao Ying Tan, Kenichi Yamahara, Masahiro Kino-Oka
Summary: Assessing the ability of cultured cells to degrade extracellular matrix (ECM) is crucial for evaluating the effectiveness of mesenchymal stem cell (MSC)-based therapies. However, current methods to assess this ability in vitro are lacking. In this study, a simple culture platform using high-density collagen surfaces was developed to study the ECM remodeling potential of cultured MSCs. This platform was used to evaluate the ECM remodeling potential of long-term ex vivo-expanded MSCs in vitro.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Mijoon Lee, Zhenzhou Chen, Brittany N. Tomlinson, Major Gooyit, Dusan Hesek, Maria Raquel Juarez, Rasheeq Nizam, Bill Boggess, Elena Lastochkin, Valerie A. Schroeder, William R. Wolter, Mark A. Suckow, Jiancun Cui, Shahriar Mobashery, Zezong Gu, Mayland Chang
ACS CHEMICAL NEUROSCIENCE
(2015)
Article
Biochemical Research Methods
Kasey J. Clear, Kara M. Harmatys, Douglas R. Rice, William R. Wolter, Mark A. Suckow, Yuzhen Wang, Mary Rusckowski, Bradley D. Smith
BIOCONJUGATE CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Edward Spink, Derong Ding, Zhihong Peng, Marc A. Boudreau, Erika Leemans, Elena Lastochkin, Wei Song, Katerina Lichtenwalter, Peter I. O'Daniel, Sebastian A. Testero, Hualiang Pi, Valerie A. Schroeder, William R. Wolter, Nuno T. Antunes, Mark A. Suckow, Sergei Vakulenko, Mayland Chang, Shahriar Mobashery
JOURNAL OF MEDICINAL CHEMISTRY
(2015)
Article
Chemistry, Multidisciplinary
Renee Bouley, Malika Kumarasiri, Zhihong Peng, Lisandro H. Otero, Wei Song, Mark A. Suckow, Valerie A. Schroeder, William R. Wolter, Elena Lastochkin, Nuno T. Antunes, Hualiang Pi, Sergei Vakulenko, Juan A. Hermoso, Mayland Chang, Shahriar Mobashery
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Article
Biochemistry & Molecular Biology
Patrick R. Gonzales, Mitchell W. Pesesky, Renee Bouley, Anna Ballard, Brent A. Biddy, Mark A. Suckow, William R. Wolter, Valerie A. Schroeder, Carey-Ann D. Burnham, Shahriar Mobashery, Mayland Chang, Gautam Dantas
NATURE CHEMICAL BIOLOGY
(2015)
Article
Multidisciplinary Sciences
Ming Gao, Trung T. Nguyen, Mark A. Suckow, William R. Wolter, Major Gooyit, Shahriar Mobashery, Mayland Chang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Microbiology
Joon Lee, Woo Yang, Andrew Hostetler, Nathan Schultz, Mark A. Suckow, Kay L. Stewart, Daniel D. Kim, Hyung Soo Kim
Article
Chemistry, Medicinal
Renee Bouley, Derong Ding, Zhihong Peng, Maria Bastian, Elena Lastochkin, Wei Song, Mark A. Suckow, Valerie A. Schroeder, William R. Wolter, Shahriar Mobashery, Mayland Chang
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Oncology
Jonathan D. Ashley, Charissa J. Quinlan, Valerie A. Schroeder, Mark A. Suckow, Vincenzo J. Pizzuti, Tanyel Kiziltepe, Basar Bilgicer
MOLECULAR CANCER THERAPEUTICS
(2016)
Article
Biochemistry & Molecular Biology
Major Gooyit, Zhihong Peng, William R. Wolter, Hualiang Pi, Derong Ding, Dusan Hesek, Mijoon Lee, Bill Boggess, Matthew M. Champion, Mark A. Suckow, Shahriar Mobashery, Mayland Chang
ACS CHEMICAL BIOLOGY
(2014)
Article
Chemistry, Multidisciplinary
Jonathan D. Ashley, Jared F. Stefanick, Valerie A. Schroeder, Mark A. Suckow, Nathan J. Alves, Rikio Suzuki, Shohei Kikuchi, Teru Hideshima, Kenneth C. Anderson, Tanyel Kiziltepe, Basar Bilgicer
JOURNAL OF CONTROLLED RELEASE
(2014)
Article
Chemistry, Medicinal
Jonathan D. Ashley, Jared F. Stefanick, Valerie A. Schroeder, Mark A. Suckow, Tanyel Kiziltepe, Basar Bilgicer
JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Article
Chemistry, Multidisciplinary
Peter I. O'Daniel, Zhihong Peng, Hualiang Pi, Sebastian A. Testero, Derong Ding, Edward Spink, Erika Leemans, Marc A. Boudreau, Takao Yamaguchi, Valerie A. Schroeder, William R. Wolter, Leticia I. Llarrull, Wei Song, Elena Lastochkin, Malika Kumarasiri, Nuno T. Antunes, Mana Espahbodi, Katerina Lichtenwalter, Mark A. Suckow, Sergei Vakulenko, Shahriar Mobashery, Mayland Chang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Article
Multidisciplinary Sciences
Bridgette D. Semple, Linda J. Noble-Haeusslein, Major Gooyit, Kayleen G. Tercovich, Zhihong Peng, Trung T. Nguyen, Valerie A. Schroeder, Mark A. Suckow, Mayland Chang, Jacob Raber, Alpa Trivedi
Article
Veterinary Sciences
Kay L. Stewart, Mark A. Suckow
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2016)