Article
Immunology
Rui Tang, Shubin Lei, Liping Zhu, Yuzhen Lv, Hong Li
Summary: This study aimed to evaluate the preventative efficacy of omalizumab for seasonal allergic rhinoconjunctivitis (SARC) and explore its influencing factors. The retrospective analysis of patients' medical records found that pre-seasonal omalizumab treatment could significantly alleviate SARC-related symptoms and reduce medication use. The dosage and number of injections of omalizumab did not affect the preventative efficacy, with a single dose of 150mg achieving satisfactory outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Behavioral Sciences
Jiehong Huang, Ruoyu Li, Lixi Li, Yunping Song, Lingjing Jin
Summary: This systematic review explores the association between tic disorders (TD) and allergic diseases (AD) through literature compilation and evidence analysis. It identifies a positive correlation between TD and asthma, allergic rhinitis, and allergic conjunctivitis. Provisional tic disorder (PTD) patients are more likely to suffer from these three AD. Shared genetic and etiological factors are suggested as responsible for this AD-TD association.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Immunology
Peng Liu, Chenglin Kang, Jin Zhang, Yue Liu, Jiangqi Liu, Tianyong Hu, Xianhai Zeng, Shuqi Qiu
Summary: Allergic diseases are common and important diseases affecting many patients worldwide. Dendritic cells (DC) play a crucial role in these diseases by presenting allergens, secreting cytokines, and participating in immune regulation. However, current research on DC is limited and further exploration is needed to understand their role in different allergic diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Camilla Stefani, Luca Pecoraro, Carl-Erik Flodmark, Marco Zaffanello, Giorgio Piacentini, Angelo Pietrobelli
Summary: Several epidemiological studies have found childhood obesity to be a risk factor for asthma, while the association with allergic rhinitis, atopic dermatitis, and chronic urticaria is more conflicting. This article suggests a relationship between childhood obesity and allergic diseases, as obesity can contribute to the development of asthma through mechanical and inflammatory effects. Excess adiposity also leads to systemic inflammation, increasing the risk of asthma exacerbations. Allergic rhinitis, atopic dermatitis, food allergies, and chronic urticaria are also associated with chronic low-grade systemic inflammation seen in obese children. Further research is needed to confirm the role of fat tissue in the development of allergic diseases and explore potential therapeutic strategies.
Review
Allergy
Ming Wang, Ning Zhao, Chengshuo Wang, Zi-Bing Jin, Luo Zhang
Summary: Allergic rhinitis is a common chronic inflammatory disorder that significantly impacts patients' health and quality of life. Current treatments for allergic rhinitis are limited in their ability to restore immune balance and target specific allergens. Mesenchymal stem cells (MSCs) offer a potential therapeutic strategy for allergic rhinitis due to their immune privilege and strong immunomodulatory effects. Recent studies have investigated the use of MSCs in animal models of allergic rhinitis and have shown promising results. This review discusses the immunomodulatory effects of MSCs on allergic airway inflammation, highlights recent research on the role of MSCs in modulating immune cells, and explores the clinical potential of MSC-based therapy for allergic rhinitis.
Article
Health Care Sciences & Services
Huijun Qiu, Rui Zheng, Xinyue Wang, Zhuanggui Chen, Peiying Feng, Xuekun Huang, Yuqi Zhou, Jin Tao, Min Dai, Lianxiong Yuan, Xiangdong Wang, Luo Zhang, Qintai Yang
Summary: Based on big data analysis, it was found that allergic rhinitis and allergic conjunctivitis in Beijing and Guangzhou have significant seasonal variations, and are positively correlated with hospital outpatient visits and pollen concentration. During the COVID-19 pandemic, although most people wore masks without eye protection, the outpatient visits for allergic conjunctivitis remained at a high level.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Chemistry, Applied
Xinyu Bai, Ping Liu, Hengyan Shen, Qiaoyue Zhang, Tao Zhang, Xuejun Jin
Summary: WLJP was found to improve allergic rhinitis through various mechanisms, such as reducing inflammation levels, modulating immune responses, maintaining gut microbiota balance, repairing damaged barriers, and alleviating AR symptoms. Additionally, significant interaction between WLJP and the NLRP3 inhibitor CY-09 was observed.
CARBOHYDRATE POLYMERS
(2022)
Review
Allergy
Song - Yang, Il Hwan Lee, Minji Kim, Gwanghui Ryu, Sung-Yoon Kang, Mi-Ae Kim, Sang Min Lee, Hyun-Jung Kim, Do -Yang Park, Yong Ju Lee, Dong-Kyu Kim, Soo Whan Kim, Do Hyun Kim, Young Joon Jun, Sang Chul Park, Bong-Seong Kim, Soo Jie Chung, Hyun Jong Lee, Hyo-Bin Kim, Jeong-Hee Choi, Gil-Soon Choi, Hyeon-Jong Yang
Summary: The prevalence of allergic rhinitis (AR) and the associated socioeconomic burden have increased. Practical guidelines for AR management that consider patients' and physicians' values and preferences are needed. The Korean Academy of Asthma, Allergy and Clinical Immunology revised clinical guidelines for AR and made recommendations for AR pharmacotherapy based on a meta-analysis and review, although the evidence certainty was low. Well-designed randomized controlled trials are needed to measure appropriate outcomes.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Tejal Sunil Bhure, Prabhudatta Das, Avinash Jukanti, Dilip Kumar Mishra, Srikant Kumar Sahu, Sayan Basu, Sachin Shukla
Summary: Allergic eye diseases, especially vernal keratoconjunctivitis, have become a major concern worldwide, particularly in the paediatric population. The use of mesenchymal stem cells or their secreted products shows potential in alleviating inflammation and promoting repair of the damaged ocular surface in allergic conjunctivitis patients, with reduced side effects compared to current treatments.
MEDICAL HYPOTHESES
(2022)
Article
Immunology
Mohammad Gholami, Khodayar Ghorban, Mahvash Sadeghi, Maryam Dadmanesh, Negin Hosseini Rouzbahani, Sajad Dehnavi
Summary: This review summarizes the potential therapeutic effects of mesenchymal stem cells (MSCs) on allergic airway inflammations. The studies suggest that MSCs can modulate airway inflammation, affect inflammatory cell infiltration, balance Th1/Th2 cellular responses, disrupt humoral responses, regulate Th17/Treg cell balance, and modulate macrophage and dendritic cell function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Otorhinolaryngology
Jiayi Yang, Weidong Wang, Zhen Shen, Wei Kang, Pengfei Zhang, Xin Chen, Huajing Li, Yuan Shao, Lifeng Liu, Shaoqiang Zhang, Fang Quan
Summary: This study investigates the efficacy and safety of sublingual immunotherapy (SLIT) with A. annua allergens in patients with seasonal allergic rhinoconjunctivitis over two pollen seasons. The results show that the symptoms and medication scores of the SLIT group decreased in 2021 and remained lower than the baseline in 2022. Compared with the SLIT group, the control group showed significant improvement in efficacy indexes in 2022. Therefore, A. annua-SLIT can safely and effectively treat patients with moderate-severe seasonal allergic rhinoconjunctivitis over two pollen seasons.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Immunology
Yanlu Che, Nan Wang, Qianzi Ma, Junjie Liu, Zhaonan Xu, Qiuying Li, Jingting Wang, Yanan Sun
Summary: This study investigated the differences in nasal flora composition between patients with allergic rhinitis (AR) and non-allergic rhinitis (nAR) and their role in pathogenesis. The results showed that AR patients had a significantly higher abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity compared to nAR patients, while the abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. The study also identified specific bacterial models associated with AR and nAR, providing new insights for their treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Hyo Geun Choi, Joo-Hee Kim, Yong-Hwi An, Min Woo Park, Jee Hye Wee
Summary: The COVID-19 pandemic has led to a significant decrease in medical visits for allergic diseases, particularly allergic rhinitis and asthma, while there has been little change in the number of visits for atopic dermatitis and allergic conjunctivitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Chiel van Geffen, Constantin Heiss, Astrid Deissler, Saeed Kolahian
Summary: In this article, we summarize and critically discuss different pharmacological approaches to modulate the generation, activation, and recruitment of MDSCs in vitro and in vivo, and their potential role in future immunosuppressive therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Monika Marko, Rafal Pawliczak
Summary: This study aimed to evaluate the efficacy and safety of oral antihistamines, intranasal antihistamines, intranasal glucocorticosteroids, subcutaneous immunotherapy, and sublingual immunotherapy in the treatment of allergic rhinitis. The results showed that these treatment methods were effective and safe in reducing the symptoms of seasonal and perennial allergic rhinitis.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
