Article
Pharmacology & Pharmacy
Filomena Amoroso, Eduardo Ibello, Federica Saracino, Federica Cermola, Giovanna Ponticelli, Enrica Scalera, Francesca Ricci, Gino Villetti, Gilda Cobellis, Gabriella Minchiotti, Eduardo Jorge Patriarca, Dario De Cesare, Cristina D'Aniello
Summary: Small molecules that can modulate or stabilize cell-cell interactions are valuable tools for investigating the impact of collective cell behavior on various biological processes. Budesonide, an anti-asthmatic drug, has been shown to be a potent regulator of stem cell pluripotency. In this study, a derivative of budesonide called CHD-030498 was identified as a more effective analogue that can prevent stem cell pluripotency exit in different cell-based models at lower doses compared to budesonide.
Article
Medicine, General & Internal
David Goodman-Meza, Chelsea L. Shover, Jesus A. Medina, Amber B. Tang, Steven Shoptaw, Alex A. T. Bui
Summary: In this diagnostic study, NLP/ML algorithms demonstrated excellent diagnostic performance at classifying substances related to overdoses. These algorithms should be integrated into workflows to decrease the lag time in reporting overdose surveillance data.
Article
Multidisciplinary Sciences
S. Guddala, F. Komissarenko, S. Kiriushechkina, A. Vakulenko, M. Li, V. M. Menon, A. Alu, A. B. Khanikaev
Summary: Topological photonics offers enhanced control over electromagnetic fields by providing a platform for robust trapping and guiding of topological states of light, enabling the control and guidance of hybrid states of light and lattice vibrations. The observed topological edge states of phonon-polaritons carry nonzero angular momentum locked to their propagation direction, enabling their robust transport.
Article
Pharmacology & Pharmacy
Katarzyna Asendrych-Wicik, Jakub Zarczuk, Katarzyna Walaszek, Tomasz Ciach, Magdalena Markowicz-Piasecka
Summary: The ocular delivery route poses challenges in terms of drug administration and bioavailability. This review focuses on the analysis and quality assessment of glaucoma treatments. Impurity profiling and stability-indicating analytical methods are important for assessing the quality of PGF2 alpha analogues. The development of more specific and accurate methods is crucial for determining content and related substances.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Inorganic & Nuclear
Rebecca J. Salthouse, Amit Sil, Louise F. Gildea, Dmitry S. Yufit, J. A. Gareth Williams
Summary: 2,6-Dipyridylbenzene derivatives are known ligands for brightly luminescent Pt(II) complexes. In this study, nonsymmetrical systems of this type, where the two heterocycles are different, were investigated. The emission generally originates from the lower-energy π* orbitals of the heterocycle, but an isoquinoline complex showed dual emission at room temperature. Isoquinoline also favored the formation of bright excimers at higher concentrations. New platinum(II) complexes with seven different ligands were synthesized and their absorption and emission properties were compared with symmetrical complexes. In addition, the unusual emission behavior of (PtLCl)Cl_1, which involves both pyridine and isoquinoline rings, was attributed to thermally activated repopulation of the excited state.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Linghan Zhu, Haonan Wang, Li Yang
Summary: In this study, we reveal a remarkable many-electron effect where doped carriers form a 2D plasmon and strongly couple with quasiparticles to renormalize moire potential and achieve ultra-flat bands. We demonstrate this effect in twisted MoS2/WS2 heterobilayer and predict that doping can effectively control the competition between correlated mechanisms, potentially leading to a quantum transition between Mott and charge-transfer insulating states.
NPJ COMPUTATIONAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Shogo Sumiyoshi, Keitaro Suyama, Naoki Tanaka, Takumi Andoh, Akihiko Nagata, Keisuke Tomohara, Suguru Taniguchi, Iori Maeda, Takeru Nose
Summary: This study synthesized truncated elastin-like peptide (ELP) analogues by shortening the amino acid sequence and found that the coacervation ability of truncated ELPs is affected by the amino acid sequence rather than the peptide chain length. Among the novel truncated ELP analogues, the 16-mer (FPGV)4 exhibited stronger coacervation ability than the 25-mer (FPGVG)5, and it could also capture Cd2+. These findings suggest that the 16-mer (FPGV)4 composed of proteinogenic amino acids can serve as a new biomaterial with minimal environmental impact.
SCIENTIFIC REPORTS
(2022)
Article
Physics, Multidisciplinary
Shuangzan Lu, Hyoungdo Nam, Penghao Xiao, Mengke Liu, Yanping Guo, Yusong Bai, Zhengbo Cheng, Jinghao Deng, Yanxing Li, Haitao Zhou, Graeme Henkelman, Gregory A. Fiete, Hong-Jun Gao, Allan H. MacDonald, Chendong Zhang, Chih-Kang Shih
Summary: The study created a hybrid magnetism/superconductivity (M=SC) system with only sp electronic levels by placing a PTCDA molecular monolayer on ultrathin Pb films. The magnetic moments come from unpaired molecular orbitals due to interfacial charge transfers. Distinct tunneling spectroscopic features of a Kondo screened pi electron impurity lattice in the regime of TK >> Δ were observed, indicating the formation of a two-dimensional bound states band.
PHYSICAL REVIEW LETTERS
(2021)
Article
Materials Science, Multidisciplinary
Xiaoming Cai
Summary: We investigate a non-Hermitian Aubry-Andre-Harper model with nonreciprocal hoppings and complex quasiperiodical potentials, and introduce boundary-dependent self-dualities to describe its Asymmetrical Anderson localization and topological phase transitions analytically. The study reveals that Anderson localization does not necessarily align with topological phase transitions, and in the localized phase, single-particle states exhibit asymmetric localization due to non-Hermitian skin effect, with energy-independent localization lengths. Possible experimental detections of the results in electric circuits are also discussed.
Article
Multidisciplinary Sciences
Anna M. Seiler, Fabian R. Geisenhof, Felix Winterer, Kenji Watanabe, Takashi Taniguchi, Tianyi Xu, Fan Zhang, R. Thomas Weitz
Summary: This study reports the observation of a cascade of correlated phases in Bernal bilayer graphene, including Stoner ferromagnets and a topologically non-trivial crystal, providing new possibilities for studying strongly correlated electrons in a simple system.
Article
Chemistry, Physical
Alexander M. Berezhkovskii, Irina V. Gopich, Attila Szabo
Summary: Kramers' procedure for calculating the rate of activated processes involves partitioning space and establishing a nonequilibrium steady state. An alternative procedure estimates the first non-zero eigenvalue of the operator that describes the dynamics. This work explores the relationship between these approaches for diffusive dynamics and shows their equivalence in special cases.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Nanoscience & Nanotechnology
Yang Xu, Kaifei Kang, Kenji Watanabe, Takashi Taniguchi, Kin Fai Mak, Jie Shan
Summary: Twisting the AB-homobilayer of WSe2 enables the realization of bilayer Hubbard model in the weak interlayer hopping limit, leading to observation of competing electronic states transition.
NATURE NANOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Shen Zhao, Zhijie Li, Xin Huang, Anna Rupp, Jonas Goeser, Ilia A. Vovk, Stanislav Yu. Kruchinin, Kenji Watanabe, Takashi Taniguchi, Ismail Bilgin, Anvar S. Baimuratov, Alexander Hoegele
Summary: Moire effects in vertically stacked 2D crystals can lead to new quantum materials with rich transport and optical phenomena. However, due to finite elasticity, the superlattices can transform into periodically reconstructed patterns. In this study, the concept of lattice reconstruction is expanded to the mesoscopic scale, and its consequences in optical studies of excitons in MoSe2-WSe2 heterostructures are demonstrated.
NATURE NANOTECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Max Attwood, Hiroki Akutsu, Lee Martin, Toby J. Blundell, Pierre Le Maguere, Scott S. Turner
Summary: The synthesis and characterization of a novel amide-functionalised ligand and its iron complex salts indicate a spin-crossover phenomenon, with differences in crystal structures between low and high spin states attributed to inter-molecular hydrogen bonding.
DALTON TRANSACTIONS
(2021)
Review
Chemistry, Multidisciplinary
Hao-Fan Wang, Cheng Tang, Chang-Xin Zhao, Jia-Qi Huang, Qiang Zhang
Summary: This review summarizes recent progress on the electrocatalysis of emerging graphene derivatives and analogues. It discusses the advantages of 2D graphene derivatives and analogues for efficient electrocatalysis, and introduces new advances in the field, including twisted graphene superlattices, molecular-level single-atom catalysts, and graphene-supported dual-atom catalysts or atomic clusters. The review also explores emerging research directions of graphene analogues for electrocatalysis, such as 2D metal-free materials, metallenes, 2D transition metal borides (MBenes), and new design strategies.
ADVANCED FUNCTIONAL MATERIALS
(2022)