期刊
ACS CHEMICAL BIOLOGY
卷 6, 期 10, 页码 1029-1035出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb2001395
关键词
-
资金
- National Institutes of Health [AG021518]
Identification of pathways of drug metabolism provides critical information regarding, efficacy and safety of these compounds. Particularly challenging cases involve stereospecific processes. We found that broad classes of compounds containing methylsulfinyl groups are reduced to methylsulfides specifically by methionine sulfoxide reductase A, which acts on the S-stereomers of methionine sulfoxides, whereas the R-stereomers of these compounds could not be efficiently reduced by any methionine sulfoxide reductase m mammals. The findings of efficient reduction. of S-methylsulfinyls and deficiency in the reduction of R-methylsulfinyls by methionine sulfoxide reductases suggest strategies for improved efficacy and decreased toxicity of drugs and natural compounds containing methylsulfinyls through targeted use of their enantiomers.
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