Review
Polymer Science
Weixing Chen, Yue Ming, Min Wang, Mingshu Huang, Hongyu Liu, Yisheng Huang, Zhijie Huang, Ling Qing, Qin Wang, Bo Jia
Summary: Regenerative medicine aims to transform clinical medicine through curative strategies, and the development of this field relies on multifunctional biomaterials. Hydrogels, which resemble the natural extracellular matrix and have good biocompatibility, are of interest in bioengineering and medical research. However, traditional hydrogels lack sufficient internal structure and cross-linking modes to achieve desired functions and stability. Introducing multifunctional nanomaterials into 3D hydrogel networks addresses these limitations and enables the display of various functionalities.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
A. E. Lee, J. G. Choi, S. H. Shi, P. He, Q. Z. Zhang, A. D. Le
Summary: This study demonstrated the osteogenic and osteoinductive effects of dental pulp stem cell-derived extracellular vesicles (DPSC-EVs) on jawbone regeneration. DPSC-EVs efficiently promoted the expression of osteogenic genes and the differentiation capability of jawbone marrow-derived mesenchymal stem cells (JB-MSCs) in vitro, and exhibited comparable pro-osteogenic effects to the FDA-approved growth factor BMP-2. In vivo, local treatment with DPSC-EVs resulted in fast wound closure and increased new bone density in a mandibular bone defect model in rats.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Engineering, Biomedical
Sania Ghobadi Alamdari, Abbas Alibakhshi, Miguel de la Guardia, Behzad Baradaran, Reza Mohammadzadeh, Mohammad Amini, Prashant Kesharwani, Ahad Mokhtarzadeh, Fatemeh Oroojalian, Amirhossein Sahebkar
Summary: This article introduces the use of synthetic and natural polymer hydrogels, nanocarbon-based hydrogels, and other nanoparticle-based materials in cardiac tissue engineering, with a focus on conductive nanostructured hydrogels.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Tingting Yu, Lingyun Zhang, Xueyu Dou, Rushui Bai, Hufei Wang, Jie Deng, Yunfan Zhang, Qiannan Sun, Qian Li, Xing Wang, Bing Han
Summary: Development of artificial biomaterials that mimic the extracellular matrix of bone tissue is a promising strategy for bone regeneration. However, the current hydrogel substitutes have inhomogeneous networks and weak mechanics, which greatly hinder their clinical applications. In this study, a dual crosslinked gelling system with tunable architectures and mechanics was developed to promote osteogenic capacity. The hybrid hydrogel showed outstanding osteogenic potential both in vitro and in vivo, and a key epigenetic regulator of ten-eleven translocation 2 (Tet2) was discovered to play a significant role in promoting osteogenesis.
Article
Materials Science, Multidisciplinary
Hussein M. El-Husseiny, Eman A. Mady, Walaa A. El-Dakroury, Moataz B. Zewail, Mina Noshy, Amr M. Abdelfatah, Ahmed S. Doghish
Summary: Bone tissue engineering plays a crucial role in repairing bone defects by combining biomolecules, biomimetic scaffolds, and cells to provide smart and complex platforms that enhance the limited self-healing capacity.
APPLIED MATERIALS TODAY
(2022)
Article
Engineering, Biomedical
Zhong Li, Shiqi Xiang, Zixuan Lin, Eileen N. Li, Haruyo Yagi, Lauren Yocum, La Li, Katherine K. Bruce, Madalyn R. Fritch, Huanlong Hu, Bing Wang, Peter G. Alexander, Khiam Aik Khor, Rocky S. Tuan, Hang Lin
Summary: This study successfully enhanced the osteogenic capability of hMSCs by incorporating graphene oxide-based nanosheets into GelMA. Both in vitro and in vivo experiments demonstrated the tremendous potential of this technology, providing new possibilities for bone tissue engineering applications.
Review
Polymer Science
Kapender Phogat, Subrata Bandhu Ghosh, Sanchita Bandyopadhyay-Ghosh
Summary: There has been significant interest in developing injectable hydrogel scaffolds for efficient healing and regeneration of defective bone tissues. These scaffolds can be injected into irregularly shaped defects and act as a reservoir for necessary components for bone tissue repair. The trend is to develop nanocomposite scaffolds that mimic the hierarchical nanostructure and composition of natural bone by combining biopolymers and inorganic nanofillers. The ability to tailor these scaffolds to patient-specific bone properties leads to better biological responses.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Engineering, Biomedical
Wentao Wang, Xiaolong Liang, Kai Zheng, Gaoran Ge, Xu Chen, Yaozeng Xu, Jiaxiang Bai, Guoqing Pan, Dechun Geng
Summary: Exosomes, small vesicles with the ability of vesicle-mediated intercellular signal transmission, have played an important role in bone tissue engineering. Compared to cells, exosomes have the advantage of cell-free therapy, which can promote bone regeneration and overcome immune rejection.
MATERIALS TODAY BIO
(2022)
Review
Nanoscience & Nanotechnology
Mingyu Lee, Min Chul Kim, Jae Young Lee
Summary: Cardiovascular disease is a leading cause of death, and biomaterial-based tissue engineering approaches have shown promise in cardiac repair. This review focuses on the use of nanomaterial-incorporated conductive hydrogels for improving cardiac function post-myocardial infarction.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Nanoscience & Nanotechnology
Chengcheng Du, Wei Huang
Summary: Nanocomposite hydrogels, with excellent biocompatibility and mechanical strength, have significant potential in bone tissue engineering. By modifying the properties and compositions of nanomaterials, the physical, chemical, and biological properties of nanocomposite hydrogels can be enhanced.
Review
Pharmacology & Pharmacy
Shuqin Zhang, Denghui Xie, Qun Zhang
Summary: This review summarizes the current status and prospects of bone regeneration therapy, introducing the roles of scaffolds and stem cells in tissue engineering, common treatment strategies for bone metabolism-related diseases, and the direction for further development.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Polymer Science
Jianghong Huang, Fei Liu, Haijing Su, Jianyi Xiong, Lei Yang, Jiang Xia, Yujie Liang
Summary: Nanocomposite hydrogels, with their ability to mimic natural cartilage structure and exhibit nano-bio effects in response to external stimuli, show great potential as scaffold materials for cartilage tissue engineering. This review article summarizes the recent advances in nanocomposite hydrogels for artificial cartilage, including their preparation methods and application scope, while also highlighting the challenges faced in using hydrogel nanocomposites for cartilage repair.
Article
Engineering, Biomedical
Matthew L. Bedell, Angelica L. Torres, Katie J. Hogan, Ziwen Wang, Bonnie Wang, Anthony J. Melchiorri, K. Jane Grande-Allen, Antonios G. Mikos
Summary: The investigation of novel hydrogel systems in osteochondral tissue engineering is important for understanding the relationship between biomaterials, cells, and other factors. This study explored the use of 3D printing to fabricate hydrogel environments that mimic tissue-specific architectures. The researchers characterized a methacryloylated gelatin composite hydrogel system and investigated the effects of additives on bone and cartilage-like matrix deposition and genetic markers in human mesenchymal stem cells (hMSCs). New assays were developed to study the effects of different bioinks and printing techniques, and viable constructs with encapsulated hMSCs were successfully printed. The results demonstrate the potential of these novel hydrogel formulations for promoting osteochondral phenotypes and highlight the importance of bioink additives in printability.
Article
Polymer Science
Krishnamurithy Genasan, Mohammad Mehrali, Tarini Veerappan, Sepehr Talebian, Murali Malliga Raman, Simmrat Singh, Sasikumar Swamiappan, Mehdi Mehrali, Tunku Kamarul, Hanumantha Rao Balaji Raghavendran
Summary: The study investigated the physicochemical, biocompatible, and osteoinductive properties of gellan-chitosan incorporated with different percentages of calcium silicate in human bone-marrow mesenchymal stromal cells (hBMSCs). Results showed that the 40% calcium silicate incorporation exhibited the most promising osteogenic potential in hBMSCs, making it a potential biomaterial for treating critical bone defects.
Review
Engineering, Biomedical
Xiaojie Liu, Tao Fang, Ting Shi, Yun Wang, Guanying Liu
Summary: The anatomical and physiological architecture of the craniofacial bone is complex, making precise management of osteogenesis crucial for regeneration of any deficiencies in this area. Stem-based tissue engineering approaches offer a safer and more cost-effective way to induce bone growth compared to traditional surgical intervention. Mesenchymal stem/stromal cells (MSCs) have pluripotent differentiation potential, anti-inflammatory and immunomodulatory properties that make them versatile in bone tissue therapies. Hydrogels, with their excellent swelling capabilities and similarity to natural extracellular matrices, are preferred choices for mediating cell growth and adapting to 3D environments. Due to their biocompatibility and ability to stimulate bone regeneration, hydrogels have become a topic of great interest in bone tissue engineering. This review explores the potential of MSC-based regenerative skeletal therapies and the application of hydrogel scaffolds as artificial bone microenvironments for stem cells in craniofacial bone tissue engineering.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Review
Pharmacology & Pharmacy
Seyedeh Maryam Hosseinikhah, Fatemeh Gheybi, Seyedeh Alia Moosavian, Mohammad-Ali Shahbazi, Mahmoud Reza Jaafari, Mika Sillanpaa, Prashant Kesharwani, Seyedeh Hoda Alavizadeh, Amirhossein Sahebkar
Summary: This article summarizes the important role of tumor-derived exosomes in cancer pathogenesis and resistance to therapy, as well as their applications and prospects in diagnosis and treatment.
JOURNAL OF DRUG TARGETING
(2023)
Article
Biotechnology & Applied Microbiology
Hamid Eshaghzadeh, Maryam Shahbazi, Sobhan Rana Akhavan, Leonel Pereira
Summary: This study compares different purification methods for extracting R-PE from Caspian Sea red macroalga. Response surface methodology was used to optimize the preliminary purification conditions and obtain the highest purity and concentration of R-PE. The effects of different treatments on R-PE purity and recovery yield were also evaluated, with PECE + AC + IE method showing the highest purity and recovery yield.
JOURNAL OF APPLIED PHYCOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Arezoo Mohammadian Farsani, Fatemeh Rahimi, Nayere Taebnia, Mahdieh Salimi, Ayyoob Arpanaei
Summary: In this study, a magnetic nanocomposite system composed of magnetite nanoparticles coated with silica shell (MSNPs) was prepared and conjugated with CD9 antibody (AntiCD9) using different strategies. The MSNPs were able to efficiently isolate exosomes from various samples and showed higher recovery efficiency compared to traditional methods. The results suggest that magnetic nanocomposites are a promising tool for the simple and fast isolation of exosomes for diagnosis applications.
Review
Gastroenterology & Hepatology
Nayere Taebnia, Ute Romling, Volker M. Lauschke
Summary: Enteric bacterial infections are a major cause of disease and mortality worldwide, especially in developing countries. In vitro 2D monolayer cultures have provided valuable insights into the virulence mechanisms of various pathogens, leading to the discovery of potential targets for antimicrobial therapy and vaccines. More complex models, such as organoids, 3D bioengineered scaffolds, and microphysiological devices, have expanded our understanding of the effects of physiological and biological factors on infection. Advances in ex vivo cultures and intravital imaging have also allowed for the study of enteric pathogens on fluid secretion, barrier integrity, and immune cell surveillance. The combined use of these different methods promises to enhance our understanding of host-microbe interactions and their impact on intestinal health.
Article
Optics
Anahita Taherkhani, Mohammad Shahbazi, Jaber Nasrollah Gavgani
Summary: In this study, a thermally reduced graphene oxide-manganese dioxide (TRGO-MnO2) hybrid was synthesized using an in-situ thermal-chemical method. MnO2 nanoparticles (NPs) with a size of 20-30 nm were uniformly dispersed on TRGO nanosheets. The deposition of MnO2 NPs on TRGO significantly improved the performance of silicon solar cells, reducing emission and enhancing the quantum efficiency from 5.8% to 9.5%. These results suggest that TRGO and TRGO-MnO2 hybrid could be promising materials for highly efficient heterocontacts in silicon solar cells.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Matteo Paolieri, Zihao Chen, Firoz Babu Kadumudi, Morteza Alehosseini, Melanie Zorron, Alireza Dolatshahi-Pirouz, Hajar Maleki
Summary: In order to adapt to the era of IoT and AI, there is a need for biocompatible, elastic, and self-healing soft electronic devices, such as wearable sensors. Inspired by the adhesive properties of marine organisms, a library of materials was synthesized and fabricated, including adhesive, self-healable, and stretchable gum-like materials, hydrogels, and aerogels. The resulting materials exhibit mussel-inspired adhesiveness, mechanical flexibility, electrical conductivity, and self-healing features. These materials have potential applications in soft electronic devices, such as electronic skins and wearable pressure sensors.
ACS APPLIED NANO MATERIALS
(2023)
Article
Engineering, Biomedical
Mehdi Azizi, Rana Jahanban-Esfahlan, Hadi Samadian, Masoud Hamidi, Khaled Seidi, Alireza Dolatshahi-Pirouz, Amirhossein Ahmadieh Yazdi, Amin Shavandi, Sophie Laurent, Mahsa Be Omide Hagh, Nahid Kasaiyan, Helder A. Santos, Mohammad-Ali Shahbazi
Summary: In the past three decades, nanoscience has provided a unique solution for reducing the systemic toxicity and increasing therapeutic efficiency of chemotherapy drugs. However, the poor accumulation and pharmacokinetics of nanoparticles hinder their translation into clinical use. New findings suggest that the efficacy based on enhanced permeability and retention may be as low as 1%. This review focuses on the current barriers, available solutions, and strategies for efficient drug delivery using nanocarriers and the tumor environment.
MATERIALS TODAY BIO
(2023)
Article
Pharmacology & Pharmacy
Carmine D'Amico, Flavia Fontana, Nesma El-Sayed, Khalil Elbadri, Alexandra Correia, Antti Rahikkala, Jukka Saarinen, Mohammad-Ali Shahbazi, Helder A. Santos
Summary: This study focuses on the use of polymeric microneedles (MNs) for transdermal drug delivery, which is a noninvasive and convenient method. A double-layered MN formulation comprising a dissolvable layer and a hydrogel-forming layer is developed. The formulation exhibits faster drug release followed by a slower release, leading to extended bioavailability. Preliminary results show that the MN formulation is effective in pain relief and inflammation reduction. The study confirms the short-term stability of the MN formulation, including its mechanical properties and drug distribution within MNs using CARS microscopy. Overall, the double-layered MN formulation holds significant potential for transdermal drug delivery.
ADVANCED THERAPEUTICS
(2023)
Article
Engineering, Biomedical
Milan Finn Wesseler, Nayere Taebnia, Sean Harrison, Sonia Youhanna, Lena C. Preiss, Aurino M. Kemas, Akos Vegvari, Jaroslav Mokry, Gareth J. Sullivan, Volker M. Lauschke, Niels B. Larsen
Summary: This study presents an accurate liver microphysiological system (MPS) created through engineering of 3D printed hydrogel chips with synthetic vasculature channels. The MPS allows the long-term culture of human liver cells and demonstrates improved molecular phenotypes compared to other 3D culture methods. The platform also successfully generates physiologically relevant oxygen gradients and shows zonation-specific toxicity patterns.
ACTA BIOMATERIALIA
(2023)
Editorial Material
Environmental Sciences
Iker Egana, Saioa Domingo-Echaburu, Gorka Orive, Unax Lertxundi
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Oncology
Ali Zarrabi, David Perrin, Mahboubeh Kavoosi, Micah Sommer, Serap Sezen, Parvaneh Mehrbod, Bhavya Bhushan, Filip Machaj, Jakub Rosik, Philip Kawalec, Saba Afifi, Seyed Mohammadreza Bolandi, Peiman Koleini, Mohsen Taheri, Tayyebeh Madrakian, Marek J. Los, Benjamin Lindsey, Nilufer Cakir, Atefeh Zarepour, Kiavash Hushmandi, Ali Fallah, Bahattin Koc, Arezoo Khosravi, Mazaher Ahmadi, Susan Logue, Gorka Orive, Stevan Pecic, Joseph W. Gordon, Saeid Ghavami
Summary: Rhabdomyosarcoma is a rare cancer that affects skeletal muscle, primarily in children and young adults. The treatment strategies for this disease include multi-agent chemotherapies following surgical resection and radiotherapy. This review provides a detailed clinical understanding of rhabdomyosarcoma, including its classification, diagnosis, and treatment strategies. The impact of apoptosis, macro-autophagy, and the unfolded protein response on chemotherapy response is discussed. Additionally, the use of in vivo mouse and zebrafish models and in vitro three-dimensional bioengineering models for screening future therapeutic approaches and promoting muscle regeneration is explored.
Article
Biochemistry & Molecular Biology
Nazanin Moazeni, Saeed Hesaraki, Aliasghar Behnamghader, Javad Esmaeilzadeh, Gorka Orive, Alireza Dolatshahi-Pirouz, Shokoufeh Borhan
Summary: In this study, a novel composite bone cement based on calcium sulfate hemihydrate and Mg, Sr-containing bioactive glass was developed. The results showed that adding glass powder improved the setting time and microscopic morphology of the cement, increased injection force, and improved cell proliferation and calcein measurements. This composite cement has potential applications in bone repair, but further evaluations are needed.
Article
Biochemistry & Molecular Biology
Mikkel O. Norgard, Philip M. Lund, Nazmie Kalisi, Thomas L. Andresen, Jannik B. Larsen, Stefan Vogel, Per Svenningsen
Summary: Extracellular vesicle (EV) secretion rate is increased by hypoxia-induced reactive oxygen species (ROS) production via the mitochondrial electron transport chain (ETC) and hypoxia-induced factor (HIF)-1 signaling. Stimulation of ETC by dichloroacetic acid (DCA) significantly increases EV secretion, which can be blocked by the antioxidant TEMPO and rotenone, an inhibitor of Complex I in the ETC. Inhibition of Complex III using antimycin A or blocking the mevalonate pathway and tyrosine metabolites with pitavastatin and 4-nitrobenzoate, respectively, enhances ROS-dependent EV secretion. These findings demonstrate that hypoxia-mimetics targeting the ETC can modify EV secretion, and ROS produced by the ETC acts as a potent stimulus for EV secretion.
Review
Biochemistry & Molecular Biology
Muhammad Umar Aslam Khan, Goran M. Stojanovic, Mohd Faizal Bin Abdullah, Alireza Dolatshahi-Pirouz, Hany E. Marei, Nureddin Ashammakhi, Anwarul Hasan
Summary: Tissue engineering is an advanced biomedical approach that utilizes smart hydrogels to repair and regenerate damaged tissues, treating patients with lost or failed organs or tissues. These hydrogels offer controllable properties, such as tunable mechanical characteristics and biocompatibility, making them ideal for tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Thermodynamics
Faezeh Rostamian, Nasrin Etesami, Mehdi Mehrali
Summary: In this study, microencapsulation of phase change materials (PCMs) was conducted for temperature management of satellite electronic boards. The synthesized microcapsules showed stability and a significant delay in reaching critical temperature, indicating the effectiveness of microencapsulated PCMs (MPCMs) in temperature management. The results demonstrate that MPCMs are a promising approach for managing the temperature of satellite electronic boards.
APPLIED THERMAL ENGINEERING
(2024)
