Review
Immunology
Fabian Flores-Borja, Paul Blair
Summary: This article discusses the induction of regulatory B cells in the tumour microenvironment and their role in suppressing anti-tumour responses. The article also explores the therapeutic implications of inhibiting Bregs in cancer. It highlights the importance of understanding the heterogeneity of Bregs and their interactions with other immune cells and the tumour itself in developing potential therapeutic tools to promote anti-tumour responses.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Laurence C. Chen, Yvonne Y. Chen
Summary: Key nutrients for immune cells are lacking in tumors, but engineered cancer-invasive bacteria can convert tumor waste into metabolic fuel to enhance anti-cancer immune responses in mice.
Review
Immunology
Prerana Muralidhara, Vanshika Sood, Vishnu Vinayak Ashok, Kushagra Bansal
Summary: Immunological tolerance is critical during pregnancy to protect the semi-allogeneic fetus from immune responses. Regulatory T cells (Tregs) accumulate at the placenta in the uterus during pregnancy and confer immunological tolerance at the maternal-fetal interface. Tregs play a role in supporting proper growth of the embryo during pregnancy and their dysfunction is associated with pregnancy-related complications. Tregs also have a similar role in tumor immunity by creating a tolerogenic system.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Zeyang Chen, Yanan Zhang, Joanne Kwak-Kim, Wenjuan Wang
Summary: Maternal immune tolerance to embryos is crucial in pregnancy, and memory T cells play a critical role in this process. Dysfunction of memory T cells is associated with various pregnancy complications. Therefore, understanding the differentiation and characteristics of memory T cells, as well as their role in pregnancy, is of great importance for diagnosing and treating pregnancy-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Toru Tanaka, Naoto Sasaki, Yoshiyuki Rikitake
Summary: Tregs play a protective role in atherosclerosis by regulating immune responses to prevent and treat the development of the disease. Enhancing regulatory immune responses may be an attractive approach to treating atherosclerotic diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Fei Guo, Brandon Hancock, Alec Griffith, Hui Lin, Kaitlyn Howard, Joshua Keegan, Fan Zhang, Adam Chicoine, Laura Cahill, Julie Ng, James Lederer
Summary: This study comprehensively characterized injury-responsive Tregs in mice using multi-dimensional profiling techniques, and found that CD44(high) Tregs expand and exhibit a highly suppressive ability in response to injury, distinct from CD44(low) Tregs. Injury-induced upregulation of specific genes was observed in CD44(high) Tregs, with chemokine receptors and cell division being the most enriched functional terms in this population.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xu Guan, Pu Cheng, Ran Wei, Jiangtao Li, Shuai Jiao, Zhixun Zhao, Haipeng Chen, Zheng Liu, Zheng Jiang, Zhaoxu Zheng, Shuangmei Zou, Xishan Wang
Summary: Enlarged TDLN in non-metastatic CRC exhibits an activated anti-tumour immune profile and is associated with favorable survival outcomes. The presence of numerous immune-activating pathways and higher numbers of CD3+ and CD8+ T cells in L-TDLN suggests its potential as a prognostic indicator.
BRITISH JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Tiong Y. Lim, Elena Perpinan, Maria-Carlota Londono, Rosa Miquel, Paula Ruiz, Ada S. Kurt, Elisavet Kodela, Amy R. Cross, Claudia Berlin, Joanna Hester, Fadi Issa, Abdel Douiri, Felix H. Volmer, Richard Taubert, Evangelia Williams, Anthony J. Demetris, Andrew Lesniak, Gilbert Bensimon, Juan Jose Lozano, Marc Martinez-Llordella, Tim Tree, Alberto Sanchez-Fueyo
Summary: This study investigated the role of low-dose IL-2 (LDIL-2) in maintaining liver allograft tolerance. The results showed that LDIL-2 expanded circulating regulatory T cells (Tregs) but failed to effectively suppress antigen-specific immune responses and promote the accumulation of intrahepatic Tregs. Furthermore, LDIL-2 induced a liver transcriptional response even before immunosuppression weaning. The study was terminated after the first 6 participants failed to reach the primary endpoint, requiring reinstitution of immunosuppression.
JOURNAL OF HEPATOLOGY
(2023)
Review
Nutrition & Dietetics
Jian Tan, Jemma Taitz, Shir Ming Sun, Lachlan Langford, Duan Ni, Laurence Macia
Summary: Modern industrial practices have changed the human diet, leading to increased consumption of processed foods and increased risk of inflammatory disorders. Dietary factors can directly regulate the development of anti-inflammatory regulatory T cells (Treg) and indirectly modulate Treg differentiation by altering the composition of gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Audrey Moatti, Anais Debesset, Caroline Pilon, Asma Beldi-Ferchiou, Mathieu Leclerc, Rabah Redjoul, Frederic Charlotte, Nhu Hanh To, Adeline Bak, Yazid Belkacemi, Benoit Laurent Salomon, Fadi Issa, David Michonneau, Sebastien Maury, Jose Laurent Cohen, Allan Thiolat
Summary: This study reveals the potential of targeting TNFR2 to enhance anti-tumor responses and treat relapse of blood malignancies. The researchers also found that TNFR2 is over-expressed in Tregs from healthy donors and patients with leukemia relapse or GVHD. These findings provide new perspectives for the development of immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Bo-Jin Chen, Jing-Wen Zhao, Da-Hong Zhang, Ai-Hong Zheng, Guo-Qing Wu
Summary: Regulatory T (Treg) cells maintain immune homeostasis and play an important role in immune tolerance, autoimmune diseases, infectious diseases, organ transplantation, and tumor diseases. Targeted elimination of Treg cells can activate tumor-specific effector T cells and improve the efficiency of cancer immunotherapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Tiago R. Matos, Masahiro Hirakawa, Ana C. Alho, Lars Neleman, Luis Graca, Jerome Ritz
Summary: CD4(+) Regulatory T cells play a critical role in immune homeostasis, but their heterogeneity in different populations including newborns, healthy adults, and patients after allogeneic hematopoietic stem cell transplantation with or without chronic graft-versus-host disease has been compared. The study found that Treg heterogeneity is higher in adults and gradually increases in the first two years post-transplant, while patients with chronic graft-versus-host disease have significantly fewer distinct Treg subpopulations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Kevin Kos, Camilla Salvagno, Max D. Wellenstein, Muhammad A. Aslam, Denize A. Meijer, Cheei-Sing Hau, Kim Vrijland, Daphne Kaldenbach, Elisabeth A. M. Raeven, Martina Schmittnaegel, Carola H. Ries, Karin E. de Visser
Summary: This study reveals that tumor-associated macrophages (TAMs) contribute to the accumulation of regulatory T cells (T-regs) in breast tumors by promoting the conversion of CD4(+) T cells into T-regs. It is found that TAMs directly promote the conversion of CD4(+) T cells into T-regs through TGF-beta, and indirectly enhance the accumulation of T-regs by enhancing PD-1 expression on CD4(+) T cells.
Review
Immunology
Enitome E. Bafor, Julio C. Valencia, Howard A. Young
Summary: The immune regulation of female reproductive function plays a crucial role in fertility, disruptions in immune tolerance can lead to autoimmune subfertility or infertility. Double negative T regulatory cells (DNTregs) are emerging as effector cells capable of mediating immune tolerance in the female reproductive system, potentially providing a paradigm shift from the known roles of conventional regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Yuping Bai, Tingting He, Liyan Zhang, Qianqian Liu, Jing Yang, Ziru Zhao, Kehu Yang, Min Zhang
Summary: The relationship between FOXP3(+) Treg expression and DLBCL prognosis was not consistent across studies, potentially due to different measurement methods. Subgroup analysis suggested that higher expression of FOXP3(+) Tregs was associated with better overall survival in Asian populations.