期刊
IMMUNOLOGY
卷 146, 期 3, 页码 369-378出版社
WILEY
DOI: 10.1111/imm.12516
关键词
DNAM-1; DNAM-1 ligands; infections; natural killer cells; tumours
类别
资金
- National Natural Science Foundation of China [81172786]
- Youth Chenguang project of Science and Technology of Wuhan City [201050231077]
Natural killer (NK) cells, which can exert early and powerful anti-tumour and anti-viral responses, are important components of the innate immune system. DNAX accessory molecule-1 (DNAM-1) is an activating receptor molecule expressed on the surface of NK cells. Recent findings suggest that DNAM-1 is a critical regulator of NK cell biology. DNAM-1 is involved in NK cell education and differentiation, and also plays a pivotal role in the development of cancer, viral infections and immune-related diseases. However, tumours and viruses have developed multiple mechanisms to evade the immune system. They are able to impair DNAM-1 activity by targeting the DNAM-1 receptor-ligand system. We have reviewed the roles of DNAM-1, and its biological functions, with respect to NK cell biology and DNAM-1 chimeric antigen receptor-based immunotherapy.
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