期刊
ACS APPLIED MATERIALS & INTERFACES
卷 10, 期 40, 页码 33867-33878出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b09999
关键词
carbon nanoparticles; theranostic nanoplatform; chemo/photothermal therapy; dual-modal imaging; pH/NIR responsive drug release
资金
- Ministry of Science and Technology of China [2017YFA0104301]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA16020100]
- Key Research Program of the Chinese Academy of Sciences [ZDRW-ZS-2016-2-3]
- CAS/SAFEA International Innovation Teams program
- Collaborative Innovation Center of Suzhou Nano-Science and Technology
The combination of chemotherapy and photothermal therapy has aroused great interest due to its better antitumor effect than either single therapy alone. Herein, we report on the development of hydroxypropyl-beta-cyclodextrin functionalized Fe3O4/carbon nanoparticles (HFCNPs) for pH/near-infrared (NIR) responsive drug release, magnetic resonance/NIR fluorescence (MR/NIRFL) imaging-guided combined chemo/photothermal therapy. The high doxorubicin (DOX) loading capacity (61.2%) and controlled drug release by NIR irradiation and weak acid micro environment render HFCNPs a good vector for DOX delivery and controlled release. Moreover, the MR/NIRFL dual-modal imaging was used to define the tumor location, size, and boundary and to track the tumor accumulation of HFCNPs and their biodistribution. The efficient accumulation and prolonged retention time of the nano particles in tumor are beneficial to tumor therapy. Taking advantage of the NIR laser-induced heating and hence promoted drug permeation, remarkable tumor inhibition was realized by synergetic chemo/photothermal therapy. In conclusion, the current work offers a promising approach to the development of smart and efficient multimodal cancer-targeted nanotheranostics.
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