Sensing ofMycobacterium tuberculosisand consequences to both host and bacillus

Navigating through the maze of TLR2 mediated signaling network for better mycobacterium infection control

(2014) Xiaowen Yu et al.   BIOCHIMIE

The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression

(2014) Vanesa G. Martinez et al.   Cellular & Molecular Immunology

Listeria monocytogenes induces IFN  expression through an IFI16-, cGAS- and STING-dependent pathway

(2014) K. Hansen et al.   EMBO JOURNAL

Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids

(2014) Maximiliano J Jiménez-Dalmaroni et al.   Innate Immunity

NOD2-Deficient Mice Have Impaired Resistance to Mycobacterium tuberculosis Infection through Defective Innate and Adaptive Immunity

(2014) M. Divangahi et al.   JOURNAL OF IMMUNOLOGY

Dectin-1 Pathway Activates Robust Autophagy-Dependent Unconventional Protein Secretion in Human Macrophages

(2014) T. Ohman et al.   JOURNAL OF IMMUNOLOGY

The DNA Sensor, Cyclic GMP–AMP Synthase, Is Essential for Induction of IFN-β duringChlamydia trachomatisInfection

(2014) Yugen Zhang et al.   JOURNAL OF IMMUNOLOGY

Autophagy in Antimicrobial Immunity

(2014) Ligia C. Gomes et al.   MOLECULAR CELL

Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-κB pathways via TLR2

(2014) Shuqing Liu et al.   MOLECULAR IMMUNOLOGY

Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) inMycobacterium tuberculosisleads to reduced virulence in a mouse model of infection

(2014) Jun Yang et al.   MOLECULAR MICROBIOLOGY

Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population

(2013) Dawn ME Bowdish et al.   BMC Medical Genetics

Receptor-mediated recognition of mycobacterial pathogens

(2013) Kate E. Killick et al.   CELLULAR MICROBIOLOGY

Insights into phagocytosis-coupled activation of pattern recognition receptors and inflammasomes

(2013) Julien Moretti et al.   CURRENT OPINION IN IMMUNOLOGY

The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome

(2013) Hiroki Mitoma et al.   IMMUNITY

C-type Lectin MCL Is an FcRγ-Coupled Receptor that Mediates the Adjuvanticity of Mycobacterial Cord Factor

(2013) Yasunobu Miyake et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Endocytosis ofMycobacterium tuberculosisHeat Shock Protein 60 Is Required to Induce Interleukin-10 Production in Macrophages

(2013) Nazia Parveen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Mycobacterium tuberculosis but Not Nonvirulent Mycobacteria Inhibits IFN-  and AIM2 Inflammasome-Dependent IL-1  Production via Its ESX-1 Secretion System

(2013) S. Shah et al.   JOURNAL OF IMMUNOLOGY

Human Gene Variants Linked to Enhanced NLRP3 Activity Limit Intramacrophage Growth of Mycobacterium tuberculosis

(2013) Daniel Eklund et al.   JOURNAL OF INFECTIOUS DISEASES

Antimicrobial Autophagy: A Conserved Innate Immune Response inDrosophila

(2013) Ryan H. Moy et al.   Journal of Innate Immunity

TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors

(2013) Jeroen van Bergenhenegouwen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Variants in toll-like receptor 9 gene influence susceptibility to tuberculosis in a Mexican population

(2013) Diana Torres-García et al.   Journal of Translational Medicine

The novel human MRC1 gene polymorphisms are associated with susceptibility to pulmonary tuberculosis in Chinese Uygur and Kazak populations

(2013) Xing Zhang et al.   MOLECULAR BIOLOGY REPORTS

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

(2013) C. J. Cambier et al.   NATURE

Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response

(2013) Jenny Carmona et al.   PLoS One

Meta-Analysis on the Associations of TLR2 Gene Polymorphisms with Pulmonary Tuberculosis Susceptibility among Asian Populations

(2013) Jia-Jia Wang et al.   PLoS One

The Scavenger Protein Apoptosis Inhibitor of Macrophages (AIM) Potentiates the Antimicrobial Response against Mycobacterium tuberculosis by Enhancing Autophagy

(2013) Lucía Sanjurjo et al.   PLoS One

Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis

(2013) R. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Type I Interferon Suppresses Type II Interferon-Triggered Human Anti-Mycobacterial Responses

(2013) R. M. B. Teles et al.   SCIENCE

The physiological role of DC-SIGN: A tale of mice and men

(2013) Juan J. Garcia-Vallejo et al.   TRENDS IN IMMUNOLOGY

Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection

(2013) C. E. Witte et al.   mBio

Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship

(2013) Volker Briken et al.   Frontiers in Cellular and Infection Microbiology

Recognition of Bacteria by Inflammasomes

(2012) Jakob von Moltke et al.   Annual Review of Immunology

A novel single nucleotide polymorphism within the NOD2 gene is associated with pulmonary tuberculosis in the Chinese Han, Uygur and Kazak populations

(2012) Mengyuan Zhao et al.   BMC INFECTIOUS DISEASES

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

(2012) Paolo S. Manzanillo et al.   Cell Host & Microbe

NOD2 enhances the innate response of alveolar macrophages to Mycobacterium tuberculosis in humans

(2012) Esmeralda Juárez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis Rv0577, a novel TLR2 agonist, induces maturation of dendritic cells and drives Th1 immune response

(2012) Eui-Hong Byun et al.   FASEB JOURNAL

Mincle is not essential for controlling Mycobacterium tuberculosis infection

(2012) Lisa Heitmann et al.   IMMUNOBIOLOGY

Mycobacterium tuberculosis Rv0652 stimulates production of tumour necrosis factor and monocytes chemoattractant protein-1 in macrophages through the Toll-like receptor 4 pathway

(2012) Kwangwook Kim et al.   IMMUNOLOGY

Critical role of AIM2 in Mycobacterium tuberculosis infection

(2012) H. Saiga et al.   INTERNATIONAL IMMUNOLOGY

Polymorphic Allele of Human MRC1 Confer Protection against Tuberculosis in a Chinese Population

(2012) Xing Zhang et al.   International Journal of Biological Sciences

Polymorphisms of NOD2 and the risk of tuberculosis: a validation study in the Chinese population

(2012) H. Pan et al.   International Journal of Immunogenetics

Evaluation of Toll-like receptor and adaptor molecule polymorphisms for susceptibility to tuberculosis in a Colombian population

(2012) D. Sánchez et al.   International Journal of Immunogenetics

R753Q Polymorphism Inhibits Toll-like Receptor (TLR) 2 Tyrosine Phosphorylation, Dimerization with TLR6, and Recruitment of Myeloid Differentiation Primary Response Protein 88

(2012) Yanbao Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Mincle in Alveolar Macrophage-Dependent Innate Immunity against Mycobacterial Infections in Mice

(2012) F. Behler et al.   JOURNAL OF IMMUNOLOGY

The mannose receptor

(2012) Luisa Martinez-Pomares   JOURNAL OF LEUKOCYTE BIOLOGY

Association between CD209 -336A/G and -871A/G Polymorphisms and Susceptibility of Tuberculosis: A Meta-Analysis

(2012) Kai Chang et al.   PLoS One

Mycobacterium tuberculosis Infection of Dendritic Cells Leads to Partially Caspase-1/11-Independent IL-1β and IL-18 Secretion but Not to Pyroptosis

(2012) Hana Abdalla et al.   PLoS One

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

(2012) E. F. Castillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association between the CD209 promoter −336A/G polymorphism and susceptibility to tuberculosis: A meta-analysis

(2012) RUIFEN MIAO et al.   RESPIROLOGY

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway

(2012) Wook-Bin Lee et al.   PLoS Pathogens

Mycobacterial signaling through toll-like receptors

(2012) Joyoti Basu et al.   Frontiers in Cellular and Infection Microbiology

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

Interaction between mannosylated lipoarabinomannan and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin influences dendritic cells maturation and T cell immunity

(2011) Tingting Wu et al.   CELLULAR IMMUNOLOGY

Arg753Gln polymorphism of the human Toll-like receptor 2 gene from infection to disease in pediatric tuberculosis

(2011) Nazan Dalgic et al.   HUMAN IMMUNOLOGY

Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice

(2011) Rafael Prados-Rosales et al.   JOURNAL OF CLINICAL INVESTIGATION

Mycobacterium tuberculosis Triggers Host Type I IFN Signaling To Regulate IL-1  Production in Human Macrophages

(2011) A. Novikov et al.   JOURNAL OF IMMUNOLOGY

The overlapping host responses to bacterial cyclic dinucleotides

(2011) Ali A. Abdul-Sater et al.   MICROBES AND INFECTION

Mycobacterium tuberculosis lipoarabinomannan enhances LPS-induced TNF-α production and inhibits NO secretion by engaging scavenger receptors

(2011) Szczepan Józefowski et al.   MICROBIAL PATHOGENESIS

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

CD36 as a lipid sensor

(2011) Céline Martin et al.   PHYSIOLOGY & BEHAVIOR

Genetic Variants in MARCO Are Associated with the Susceptibility to Pulmonary Tuberculosis in Chinese Han Population

(2011) Mai-Juan Ma et al.   PLoS One

Vitamin D Is Required for IFN- -Mediated Antimicrobial Activity of Human Macrophages

(2011) M. Fabri et al.   Science Translational Medicine

Association of TLR polymorphisms with development of tuberculosis in Indonesian females

(2011) K. Kobayashi et al.   TISSUE ANTIGENS

Prolonged survival of scavenger receptor class A-deficient mice from pulmonary Mycobacterium tuberculosis infection

(2011) Zvjezdana Sever-Chroneos et al.   TUBERCULOSIS

Early Secreted Antigen ESAT-6 of Mycobacterium tuberculosis Promotes Protective T Helper 17 Cell Responses in a Toll-Like Receptor-2-dependent Manner

(2011) Samit Chatterjee et al.   PLoS Pathogens

CD36 deficiency attenuates experimental mycobacterial infection

(2010) Michael Hawkes et al.   BMC INFECTIOUS DISEASES

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The STING pathway and regulation of innate immune signaling in response to DNA pathogens

(2010) Hiroki Ishikawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling

(2010) Dong-Min Shin et al.   CELLULAR MICROBIOLOGY

NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages

(2010) Michelle N. Brooks et al.   CELLULAR MICROBIOLOGY

Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome

(2010) Bibhuti B. Mishra et al.   CELLULAR MICROBIOLOGY

The TLR4 ASP299GLY Polymorphism is a Risk Factor for Active Tuberculosis in Caucasian HIV-Infected Patients

(2010) Ildefonso Pulido et al.   CURRENT HIV RESEARCH

Relationship between polymorphism of DC-SIGN (CD209) gene and the susceptibility to pulmonary tuberculosis in an eastern Chinese population

(2010) Ruijuan Zheng et al.   HUMAN IMMUNOLOGY

Comparison of the Moonlighting Actions of the Two Highly Homologous Chaperonin 60 Proteins of Mycobacterium tuberculosis

(2010) A. Cehovin et al.   INFECTION AND IMMUNITY

Partial Redundancy of the Pattern Recognition Receptors, Scavenger Receptors, and C-Type Lectins for the Long-Term Control of Mycobacterium tuberculosis Infection

(2010) N. Court et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate

(2010) H. Schoenen et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis Activates Human Macrophage Peroxisome Proliferator-Activated Receptor   Linking Mannose Receptor Recognition to Regulation of Immune Responses

(2010) M. V. S. Rajaram et al.   JOURNAL OF IMMUNOLOGY

The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice

(2010) Mohlopheni J. Marakalala et al.   MICROBES AND INFECTION

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1

(2010) Erin McElvania TeKippe et al.   PLoS One

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India

(2010) P. Selvaraj et al.   TUBERCULOSIS

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System

(2009) Russell E. Vance et al.   Cell Host & Microbe

TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis

(2009) Michael G. Drage et al.   CELLULAR IMMUNOLOGY

Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans

(2009) Digna Rosa Velez et al.   HUMAN GENETICS

Mycobacterial Phosphatidylinositol Mannosides Negatively Regulate Host Toll-like Receptor 4, MyD88-dependent Proinflammatory Cytokines, and TRIF-dependent Co-stimulatory Molecule Expression

(2009) Emilie Doz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dectin-1 is Inducible and Plays an Essential Role for Mycobacteria-Induced Innate Immune Responses in Airway Epithelial Cells

(2009) Hye-Mi Lee et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A murine DC-SIGN homologue contributes to early host defense againstMycobacterium tuberculosis

(2009) Antoine Tanne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage

(2009) S. Nair et al.   JOURNAL OF IMMUNOLOGY

Induction of Th1/Th17 immune response by Mycobacterium tuberculosis : role of dectin-1, mannose receptor, and DC-SIGN

(2009) Elena Zenaro et al.   JOURNAL OF LEUKOCYTE BIOLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2

(2009) Maximiliano J. Jimenez-Dalmaroni et al.   PLoS One

MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis

(2009) Dawn M. E. Bowdish et al.   PLoS Pathogens

Mycobacterium tuberculosislipoprotein-induced association of TLR2 with protein kinase C ζ in lipid rafts contributes to reactive oxygen species-dependent inflammatory signalling in macrophages

(2008) Dong-Min Shin et al.   CELLULAR MICROBIOLOGY

Containment of aerogenicMycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9

(2008) Christoph Hölscher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis

(2008) Catharina W. Wieland et al.   IMMUNOLOGY

Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole

(2008) J. Smith et al.   INFECTION AND IMMUNITY

Common Nonsynonymous Polymorphisms in theNOD2Gene Are Associated with Resistance or Susceptibility to Tuberculosis Disease in African Americans

(2008) Celest M. Austin et al.   JOURNAL OF INFECTIOUS DISEASES

Attenuated Activation of Macrophage TLR9 by DNA from Virulent Mycobacteria

(2008) Alexandra K. Kiemer et al.   Journal of Innate Immunity

CD209 Genetic Polymorphism and Tuberculosis Disease

(2008) Fredrik O. Vannberg et al.   PLoS One

Mycobacterium tuberculosis lipids regulate cytokines, TLR-2/4 and MHC class II expression in human macrophages

(2008) Luz María Rocha-Ramírez et al.   TUBERCULOSIS

The immunomodulatory lipoglycans, lipoarabinomannan and lipomannan, are exposed at the mycobacterial cell surface

(2008) Sylvain Pitarque et al.   TUBERCULOSIS