Article
Oncology
Naining Xu, Honglei Tian, Chun Po Fung, Yuntao Lin, Guang Zhu, Yuehong Shen, Hongyu Yang
Summary: This study aims to develop a new method to quantitatively evaluate and compare prodrug-activating suicide gene therapies for cancer treatment. The research was conducted on an oral squamous cell carcinoma cell line CAL-27, with suicide genes integrated to evaluate and compare the efficacy of PA suicide gene therapies. The method could be used to measure anti-cancer effects when prodrug concentration, treatment time, and rate of suicide gene-positive cells are fixed, providing valuable information for preclinical development of suicide gene therapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biophysics
Ying Xu, Peng Chen, Lei Tang, Xiaojun Zhang, Feng Shi, Xuyang Ning, Jingli Bi, Yang Qu, Hongfei Liu
Summary: In this study, a mixed micelle with tumor targeting and hypoxia responsiveness was designed for tumor therapy and imaging. The micelles showed enhanced cytotoxic effect and improved cellular uptake in vitro, especially under hypoxic conditions. In vivo experiments further demonstrated the outstanding tumor targeting and hypoxia responsive properties of the micelles.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Analytical
Kheibar Dashtian, Fatemeh Binabaji, Rouholah Zare-Dorabei
Summary: Wearable sweat sensors offer exciting opportunities for personal health monitoring and noninvasive biomarker measurements. This study presents a portable microfluidic device capable of simultaneous sweat sampling and fluorometric sensing of potential biomarkers for kidney disease monitoring. The device integrates seamlessly with smartphones for easy data retrieval and analysis. The sensors show exceptional performance, with low detection limits and remarkable selectivity. The evaluation extends to monitoring kidney diseases in real-world scenarios, showing the potential of low-cost, multidiagnostic microfluidic sensor arrays for enhanced disease detection and healthcare outcomes.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sijia Feng, Huizhu Li, Chang Liu, Mo Chen, Huaixuan Sheng, Mingru Huang, Yunxia Li, Jun Chen, Jian Zhang, Yuefeng Hao, Shiyi Chen
Summary: A PbS QDs-based second near-infrared (NIR-II) fluorescence imaging system was developed for real-time detection and monitoring of dynamic changes in bacterial infections in vivo, enabling real-time imaging of bacterial load.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Analytical
Mingce Tian, Wenjuan Zhou, Weijiang Guan, Chao Lu
Summary: This study designed a micron-sized fluorescent probe that can provide real-time 3D imaging of stress and its relaxation in the crystallization process. It was found that stress increased significantly in spherulites as a result of the suppression of stress relaxation in polymer melts. This method provides a novel approach for studying crystallization behavior and guiding the development of materials.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
J. Li, P. Liu
Summary: In this study, Cu(II)-complexed CDs (Cu(II)-CDs NPs) were designed for tumor intracellular glutathione-activated cuprous ion-mediated therapy and real-time imaging. The Cu(II)-CDs NPs could release CDs and Cu(I) ions in the intracellular environment, showing strong tumor specificity.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Lata Chouhan, Syoji Ito, Elizabeth Mariam Thomas, Yuta Takano, Sushant Ghimire, Hiroshi Miyasaka, Vasudevanpillai Biju
Summary: Despite the excellent optoelectronic properties of halide perovskites, defects such as halide vacancies can adversely affect their stability and durability. By using halide precursors to fill these vacancies, real-time suppression of nonradiative exciton recombination and photoluminescence blinking in perovskite quantum dots is achieved, leading to improved quantum efficiencies and lifetimes. Statistical analysis also reveals different types of blinking mechanisms in quantum dots before and after halide vacancy filling.
Article
Biophysics
Junjie Lin, Xiaoman Huang, Erfeng Kou, Wenxiao Cai, Haoran Zhang, Xuejie Zhang, Yingliang Liu, Wei Li, Yinjian Zheng, Bingfu Lei
Summary: A low-cost sensing platform was developed using carbon dots (CDs) as the optical probe, electronic devices for image acquisition, and a built-in algorithm program for image processing, enabling precise detection of Cu2+ in plant internal and external environments. The platform offers high spatial and temporal resolution and has the potential for real-time and remote control in agriculture.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Hou-Fu Xia, Zi-Li Yu, Li-Juan Zhang, Shu-Lin Liu, Yi Zhao, Jue Huang, Dan-Dan Fu, Qi-Hui Xie, Hai-Ming Liu, Zhi-Ling Zhang, Yi-Fang Zhao, Min Wu, Wei Zhang, Dai-Wen Pang, Gang Chen
Summary: This study proposes a single particle tracking platform using a quantum dot labeling strategy to dissect the dynamic behaviors of extracellular vesicles (EVs). The interplay between tumor cell-derived small EVs (T-sEVs) and endothelial cells (ECs) is investigated, revealing the entire process and detailed dynamics of T-sEV transportation and cargo-release in ECs. This study provides insights into the proangiogenic functions of T-sEVs and highlights the potential of the QD-based single particle tracking technique in exploring sEV-mediated cell-cell communication.
Article
Chemistry, Physical
Pawan K. Kanaujia, Mohammad Adnan, Kshetra Mohan Dehury, Mohammad Akram, G. Vijaya Prakash
Summary: Inorganic-organic (IO) hybrid semiconductors are fascinating optoelectronic materials due to their unique crystal structure, wide range of crystal phases, tunable bandgap, optical exciton characteristics, and optoelectronic properties. This study investigates the digitized intercalation process and dynamic structural deviations/evolution in mixed IO hybrid systems, resulting in the formation of 2D or 3D hybrid networks. Real-time photoluminescence monitoring reveals the progressive shift of exciton energies, providing insight into the nature of multiphase crystal packings in IO hybrid semiconductors.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Analytical
Sahil S. Kanani, Hsin-Yun Tsai, W. Russ Algar
Summary: This study reports a double-chopper design for time-gated photoluminescence (PL) imaging using a portable, 3D-printed, smartphone-based device. The device is capable of quantitative imaging of PL, including spectral and temporal multiplexing, TG-FRET assay, and cell imaging. This work is the first demonstration of these important analytical capabilities on a smartphone, providing an important foundation for developing smartphone-based POCD methods using time-gated PL imaging.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Sahil S. Kanani, Hsin-Yun Tsai, W. Russ Algar
Summary: This study presents a double-chopper design for time-gated photoluminescence imaging using a portable, 3D-printed, smartphone-based device. The device enables quantitative imaging and rejection of background fluorescence, making it useful for studying luminescent lanthanide complexes and performing spectral and temporal multiplexing. These findings lay an important foundation for developing point-of-care diagnostics methods based on time-gated photoluminescence imaging.
ANALYTICAL CHEMISTRY
(2023)
Article
Oncology
Yuan-Yuan Zhu, Liang Song, Yong-Qu Zhang, Wan-Ling Liu, Wei-Ling Chen, Wen-Liang Gao, Li-Xin Zhang, Jia-Zheng Wang, Zi-He Ming, Yun Zhang, Guo-Jun Zhang
Summary: This study developed a novel near-infrared in vivo fluorescence imaging system that can accurately detect breast cancer metastasis to the Sentinel lymph node (SLN). By combining erbium-based rare-earth nanoparticles with a peptide antagonist, the system was able to visualize metastatic tumor cells in real-time and significantly improve the detection rate of SLN metastasis.
Article
Multidisciplinary Sciences
Artem N. Abramov, Igor Y. Chestnov, Ekaterina S. Alimova, Tatiana Ivanova, Ivan S. Mukhin, Dmitry N. Krizhanovskii, Ivan A. Shelykh, Ivan V. Iorsh, Vasily Kravtsov
Summary: By using local deformation of monolayer WSe2, we have successfully created high-purity single-photon emitters. Through nanoindentation and atomic force microscopy, we have identified the single-photon emitting sites and reconstructed the details of the surrounding local strain potential. The experimental results suggest that the single-photon emission is likely due to strain-induced spectral shift of dark excitonic states and their hybridization with localized states of individual defects.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
S. Yamamoto, R. Kaji, S. Adachi
Summary: In this study, the formation of the anomalous Hanle effect in a self-assembled quantum dot was investigated using experimental and theoretical approaches. The buildup time of the nuclear field was found to increase with increasing applied transverse magnetic field strength. Additionally, the inversion of the circular polarization degree of photoluminescence was observed to occur much faster than the buildup time of the nuclear field, indicating the importance of the in-plane component of the major principal axis of nuclear quadrupole interaction.
Article
Nanoscience & Nanotechnology
Xiao-Dong Li, Zheng Wang, Xin-Rui Wang, Dan Shao, Xi Zhang, Li Li, Ming-Feng Ge, Zhi-Min Chang, Wen-Fei Dong
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Review
Chemistry, Multidisciplinary
Huize Yan, Dan Shao, Yeh-Hsing Lao, Mingqiang Li, Hanze Hu, Kam W. Leong
Article
Biophysics
Yu Han, Fan Zhang, Jing Zhang, Dan Shao, Yanan Wang, Shuang Li, Shuang Lv, Guangfan Chi, Ming Zhang, Li Chen, Jianguo Liu
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Multidisciplinary Sciences
Jianati Dawulieti, Madi Sun, Yawei Zhao, Dan Shao, Huize Yan, Yeh-Hsing Lao, Hanze Hu, Lianzhi Cui, Xiaoyan Lv, Feng Liu, Chun-Wei Chi, Yue Zhang, Mingqiang Li, Ming Zhang, Huayu Tian, Xuesi Chen, Kam W. Leong, Li Chen
Article
Chemistry, Multidisciplinary
Jing Gong, Hong-Xia Wang, Yeh-Hsing Lao, Hanze Hu, Naazanene Vatan, Jonathan Guo, Tzu-Chieh Ho, Dantong Huang, Mingqiang Li, Dan Shao, Kam W. Leong
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Feng Liu, Shu Sheng, Dan Shao, Yongqiang Xiao, Yiling Zhong, Jie Zhou, Chai Hoon Quek, Yanbing Wang, Zhiming Hu, Heshi Liu, Yanhui Li, Huayu Tian, Kam W. Leong, Xuesi Chen
Summary: A novel cfDNA-scavenging nanoparticle (NP) has been developed as a potential treatment for sepsis. This nanoparticle showed superior efficacy in scavenging circulating cfDNA, reducing inflammation, and reversing the progression of sepsis compared to naked PEI.
Article
Nanoscience & Nanotechnology
Haijun Li, Dongbei Li, Fangman Chen, Chao Yang, Xiaogai Li, Yuan Zhang, Chunlan Hua, Xiaoxu Ma, Xin Zhao, Dan Shao, Yingshuai Wang, Liang Ming
Summary: The study developed a new material, Ag-MONs@GEN, for the treatment of antibiotic-resistant bacteria, demonstrating excellent antibacterial activity against various strains through controlled release of GEN and silver ions. Furthermore, the nanoplatform showed high safety profiles in cell experiments.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Biomedical
Yanjun Yang, Fangman Chen, Ning Xu, Qichao Yao, Ran Wang, Xiaochun Xie, Fan Zhang, Yan He, Dan Shao, Wen-fei Dong, Jiangli Fan, Wen Sun, Xiaojun Peng
Summary: This study presents a red light-responsive self-destructive carrier for chemo-photodynamic therapy. The carrier achieves dual drug release and degradation of the organosilica matrix upon low-dose red light irradiation, resulting in a synergistic chemo-photodynamic effect. Furthermore, this therapy boosts immunogenic cell death and robust anti-tumor immunity responses.
Review
Nanoscience & Nanotechnology
Zhaoxu Tu, Yiling Zhong, Hanze Hu, Dan Shao, Rainer Haag, Michael Schirner, Jaewoo Lee, Bruce Sullenger, Kam W. Leong
Summary: Inflammation plays a crucial role in our body's response to injury or infection, but dysregulation can lead to chronic inflammation and inflammatory diseases. Biomaterials can enhance the efficacy of anti-inflammatory drugs by improving drug bioavailability and reducing side effects. Key elements of the inflammatory environment and the design of biomaterials for anti-inflammatory therapeutic strategies are discussed in this Review.
NATURE REVIEWS MATERIALS
(2022)
Article
Multidisciplinary Sciences
Hanyao Huang, Weiyi Pan, Yifan Wang, Hye Sung Kim, Dan Shao, Baoding Huang, Tzu-Chieh Ho, Yeh-Hsing Lao, Chai Hoon Quek, Jiayu Shi, Qianming Chen, Bing Shi, Shengmin Zhang, Lei Zhao, Kam W. Leong
Summary: Periodontitis is a common inflammatory bone loss condition that is associated with systemic diseases. The use of a nanoparticulate cfDNA scavenger shows promise in treating periodontitis by reducing inflammation and bone loss.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Jiyin Liu, Xiaochun Xie, Junna Lu, Yi He, Dan Shao, Fangman Chen
Summary: This study reported a Ru(II)-coumarin complex consisting of ruthenium, 1,10-phenanthroline, and coumarin 6, which can form self-assembled nanoprobes for cell membrane targeting and imaging. These nanoprobes exhibit high stability and reduced background interference, providing a solution for investigating lipid trafficking with optical imaging.
Article
Engineering, Biomedical
Tongfei Shi, Jingtong Zhao, Kongrong Long, Mohan Gao, Fangman Chen, Xuenian Chen, Yue Zhang, Baoding Huang, Dan Shao, Chao Yang, Liang Wang, Ming Zhang, Kam W. Leong, Li Chen, Kan He
Summary: The MSN-PEI nanoparticles prepared in this study have potential therapeutic effects in the treatment of osteoarthritis. By targeting multiple danger mediators, they can attenuate cartilage degradation and inflammation, providing strong joint protection.
Letter
Biochemistry & Molecular Biology
Xuenian Chen, Tongfei Shi, Chao Yang, Fangman Chen, Xuan He, Kunbao Zhang, Hanze Hu, Lulu Cai, Kam W. Leong, Dan Shao
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Dan Shao, Fan Zhang, Fangman Chen, Xiao Zheng, Hanze Hu, Chao Yang, Zhaoxu Tu, Zheng Wang, Zhimin Chang, Junna Lu, Tianyu Li, Yuan Zhang, Li Chen, Kam W. Leong, Wen-fei Dong
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Zhi-min Chang, Rui Zhang, Chao Yang, Dan Shao, Yuguo Tang, Wen-fei Dong, Zheng Wang