期刊
ACS APPLIED MATERIALS & INTERFACES
卷 6, 期 10, 页码 7198-7203出版社
AMER CHEMICAL SOC
DOI: 10.1021/am500324z
关键词
thiolated; nanodiamond; detonation nanodiamond; surface modification; thiolated nanodiamond; functionalized nanodiamond
资金
- National Tsing Hua University
- National Health Research Institutes [NM-102-PP-07]
- Ministry of Science and Technology, Republic of China
An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds.
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