Article
Agriculture, Dairy & Animal Science
Wootichai Kenchaiwong, Pongphol Pongthaisong, Srinuan Kananit, Monchai Duangjinda, Wuttigrai Boonkum
Summary: This study demonstrates the importance of understanding the genetic diversity of Thai swamp buffalo for conservation and breeding planning. The high genetic diversity found in this population suggests that there is potential for selecting and improving genetic tools to enhance health and production. The variations in the TLR2 gene may be useful for marker-based breeding programs aimed at improving disease resistance.
Article
Multidisciplinary Sciences
Katherine A. Farquharson, Elspeth A. McLennan, Yuanyuan Cheng, Lauren Alexander, Samantha Fox, Andrew Lee, Katherine Belov, Carolyn J. Hogg
Summary: Conservation breeding programs aim to maintain wild genetic diversity, but rarely assess functional diversity. This study compares both genome-wide and functional diversity of Tasmanian devils within the insurance metapopulation and across their range. The results show that the insurance metapopulation is representative of current wild genetic diversity.
Article
Microbiology
Rowan Durrant, Rodrigo Hamede, Konstans Wells, Miguel Lurgi
Summary: Metapopulation structure is crucial for wildlife population persistence and disease dynamics. The interaction between host dispersal, disease transmission rate, and within-population mixing plays a synergistic role in disease spread and population declines. Population isolation may reduce disease prevalence but can also lead to declines in size and genetic diversity, emphasizing the importance of considering metapopulation structure in disease control strategies.
Article
Multidisciplinary Sciences
Cleopatra Petrohilos, Amanda Patchett, Carolyn J. Hogg, Katherine Belov, Emma Peel
Summary: The Tasmanian devil is endangered due to the spread of a contagious cancer called Devil Facial Tumour Disease (DFTD). In this study, seven recently characterized Tasmanian devil cathelicidins were tested for their potential role in cancer regulation. The results showed that four cathelicidins were toxic to DFTD cells and caused cellular stress, while the most toxic peptide also suppressed important signaling pathways associated with cancer proliferation. Additionally, three cathelicidins induced inflammatory pathways in DFTD cells, potentially recruiting immune cells. These findings suggest that devil cathelicidins have potential anti-cancer and inflammatory functions that warrant further exploration as potential treatment leads.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Priscila Saamara Masin, Hugo Alves Visentin, Laise Nayana Sala Elpidio, Ana Maria Sell, Lorena Visentainer, Quirino Alves De Lima Neto, Joana Maira Valentini Zacarias, Patricia Couceiro, Andressa Higa Shinzato, Manuel Santos Rosa, Paulo Rodrigues-Santos, Jeane Eliete Laguila Visentainer
Summary: This study investigated the association between polymorphisms in TLR1 and TLR2 genes and susceptibility/protection against leprosy in southern Brazil. The results showed that certain genotypes in TLR1 and TLR2 were more frequent in the control group, suggesting a potential protective role against leprosy.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Parice A. Brandies, Belinda R. Wright, Carolyn J. Hogg, Catherine E. Grueber, Katherine Belov
Summary: Interindividual variation at genes known to play a role in reproduction may impact reproductive fitness in Tasmanian devils. The study identified functional diversity at reproductive genes, with two genes ADAMTS9 and NANOG showing putative signatures of balancing selection. Researchers will further investigate the interplay between reproductive gene variation and reproductive fitness in Tasmanian devil populations.
MOLECULAR ECOLOGY RESOURCES
(2021)
Article
Biochemistry & Molecular Biology
Lei Zhang, Guangshuai Liu, Tian Xia, Xiufeng Yang, Guolei Sun, Chao Zhao, Chunzhu Xu, Honghai Zhang
Summary: The study analyzed TLR genes from the genomes and transcriptomes of 102 amphibian species to understand their evolutionary patterns. Results showed that TLR genes can be divided into seven subfamilies, with TLR4 subfamily found only in Anura. Purification selection played a leading role in amphibian TLR evolution, and different domains had different evolution rates. Positive selection patterns and single-nucleotide polymorphisms were observed in TLR genes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biodiversity Conservation
Kang-Rae Kim, Hee-kyu Choi, Taek Won Lee, Hyuk Je Lee, Jeong-Nam Yu
Summary: The population size of the spotted sleeper, a fish endemic to Korea and with potential in aquaculture, has declined significantly in recent years. We analyzed microsatellite loci in twelve populations to characterize the population structure and genetic diversity. The results showed high microsatellite diversity but low mitochondrial DNA diversity, with evidence of genetic admixture among populations. Conservation efforts are needed due to the small effective population size and the findings provide insights for conservation strategies.
Review
Chemistry, Multidisciplinary
Xin Zhi, Peipei Yang, Yunxue Xu, Zhifei Dai, Xiuli Yue, Linxue Qian
Summary: This review discusses the functions of Toll-like receptors (TLRs) in the tumor microenvironment and the pathways that activate immune responses. It also summarizes recent developments in nanotechnology for immunomodulation with TLR agonists. Nanotechnology can improve the efficacy of TLR agonist-based immunotherapy and address its limitations.
Article
Genetics & Heredity
Shulei Sun, Yuehao Shen, Jing Feng
Summary: This study found that genetic variants in Toll-like receptors were associated with the risk of COPD, and rs3775291 and rs4696480 may act as potential biomarkers for predicting COPD risk in the Chinese population.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Yuan-Tung Chu, Min-Tser Liao, Kuo-Wang Tsai, Kuo-Cheng Lu, Wan-Chung Hu
Summary: A comprehensive framework has been established to understand immunological pathways, and specific associations between immune responses and immune receptors have been identified. These findings contribute to the identification of biomarkers for immune cells and provide insights into host immunological pathways.
Article
Fisheries
Radoslaw Wlodarczyk, Martin Tesicky, Michal Vinkler, Marian Novotny, Magdalena Remisiewicz, Tomasz Janiszewski, Piotr Minias
Summary: The study found high genetic diversity in TLR genes in bird species, with no shared nucleotide allelic variants between different species, indicating rapid evolution of TLR genes.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Review
Virology
Mohammad Kazem Vakil, Yaser Mansoori, Ghaidaa Raheem Lateef Al-Awsi, Ali Hosseinipour, Samaneh Ahsant, Sedigheh Ahmadi, Mohammad Ekrahi, Zahra Montaseri, Babak Pezeshki, Poopak Mohaghegh, Mojtaba Sohrabpour, Maryam Bahmanyar, Abdolreza Daraei, Tahereh Dadkhah Jouybari, Alireza Tavassoli, Abdolmajid Ghasemian
Summary: Innate and acquired immunity responses are crucial for eliminating viral infections. However, genetic variations in coding genes may exacerbate inflammation or initiate devastating cytokine storms, leading to severe respiratory conditions in COVID-19. Host genetic variations, particularly those related to immune responses, determine patients' susceptibility and the severity and pathophysiology of COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kirstin M. Proft, Brooke L. Bateman, Christopher N. Johnson, Menna E. Jones, Matthew Pauza, Christopher P. Burridge
Summary: It was found that weather plays an important role in driving population dynamics and species distributions on decadal timescales. Areas with highly variable weather tend to have lower genetic diversity and smaller population sizes.
Review
Genetics & Heredity
Muhammad Saif-ur Rehman, Saif Ur Rehman, Wasim Yousaf, Faiz-ul Hassan, Waqas Ahmad, Qingyou Liu, Hongping Pan
Summary: Toll-like receptors (TLRs) are essential for regulating immune responses and disease resistance in chickens. By utilizing specific feed ingredients and yeast-derived products, the immunity and disease resistance of chickens can be enhanced, providing new avenues for healthy and profitable chicken production.
FRONTIERS IN GENETICS
(2021)
Article
Zoology
Lauren J. Young, Jessica Gurr, Katrina Morris, Sabine Flenady, Katherine Belov
AUSTRALIAN MAMMALOGY
(2019)
Article
Evolutionary Biology
Catherine E. Grueber, Samantha Fox, Elspeth A. McLennan, Rebecca M. Gooley, David Pemberton, Carolyn J. Hogg, Katherine Belov
EVOLUTIONARY APPLICATIONS
(2019)
Article
Biodiversity Conservation
C. J. Hogg, B. Wright, K. M. Morris, A. Lee, J. A. Ivy, C. E. Grueber, K. Belov
ANIMAL CONSERVATION
(2019)
Article
Virology
Rowena Chong, Mang Shi, Catherine E. Grueber, Edward C. Holmes, Carolyn J. Hogg, Katherine Belov, Vanessa R. Barrs
JOURNAL OF VIROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Elspeth A. McLennan, Belinda R. Wright, Katherine Belov, Carolyn J. Hogg, Catherine E. Grueber
MOLECULAR ECOLOGY RESOURCES
(2019)
Article
Biodiversity Conservation
C. J. Hogg, E. A. McLennan, P. Wise, A. Lee, D. Pemberton, S. Fox, K. Belov, C. E. Grueber
BIOLOGICAL CONSERVATION
(2020)
Review
Genetics & Heredity
Parice Brandies, Emma Peel, Carolyn J. Hogg, Katherine Belov
Article
Biodiversity Conservation
E. A. McLennan, C. E. Grueber, P. Wise, K. Belov, C. J. Hogg
ANIMAL CONSERVATION
(2020)
Article
Evolutionary Biology
Katherine A. Farquharson, Carolyn J. Hogg, Katherine Belov, Catherine E. Grueber
EVOLUTIONARY APPLICATIONS
(2020)
Review
Microbiology
Rowena Chong, Yuanyuan Cheng, Carolyn J. Hogg, Katherine Belov
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Belinda R. Wright, Katherine A. Farquharson, Elspeth A. McLennan, Katherine Belov, Carolyn J. Hogg, Catherine E. Grueber
MOLECULAR ECOLOGY RESOURCES
(2020)
Article
Multidisciplinary Sciences
Rebecca M. Gooley, Carolyn J. Hogg, Samantha Fox, David Pemberton, Katherine Belov, Catherine E. Grueber
Article
Microbiology
Rowena Chong, Catherine E. Grueber, Samantha Fox, Phil Wise, Vanessa R. Barrs, Carolyn J. Hogg, Katherine Belov
Article
Developmental Biology
C. E. Grueber, E. Peel, B. Wright, C. J. Hogg, K. Belov
REPRODUCTION FERTILITY AND DEVELOPMENT
(2019)
Article
Biology
Yuanyuan Cheng, Mariano Makara, Emma Peel, Samantha Fox, Anthony T. Papenfuss, Katherine Belov
COMMUNICATIONS BIOLOGY
(2019)
