Article
Biochemistry & Molecular Biology
Nicole M. Paterson, Hussein Al-Zubieri, Matthew F. Barber
Summary: The study focuses on the divergence of CD1 genes among simian primate species, indicating that lipid-protein conflicts have shaped genetic variation during primate evolution. Multiple CD1 family proteins in primates show signs of repeated positive selection at surfaces impacting antigen presentation, binding pocket morphology, and T-cell receptor accessibility.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Genetics & Heredity
Paula Montana-Lozano, Sergio A. Balaguera-Reina, Carlos F. Prada-Quiroga
Summary: The study on reptile mitochondrial genomes reveals differences in base composition and codon usage patterns. Reptile mitochondrial genomes have low GC content with a bias towards Adenine, and the compositional asymmetry is inversely correlated with the rates of genome rearrangements. The most common codons in reptile mitochondria are shared with birds, indicating a conservation of patterns across sauropsid mitogenomes. Analysis on codon usage bias clustering and effective codon number suggests high translational efficiency and selection pressure in reptile mitochondrial genomes. The highest codon adaptation index is found in turtles, suggesting higher translational efficiency and potential metabolic adaptations.
Article
Ecology
Samantha L. Bock, Yeraldi Loera, Josiah M. Johnson, Christopher R. Smaga, David L. Haskins, Tracey D. Tuberville, Randeep Singh, Thomas R. Rainwater, Philip M. Wilkinson, Benjamin B. Parrott
Summary: The study provides the first empirical support for the adaptive value of temperature-dependent sex determination (TSD) in crocodilians, showing that incubation temperature influences the annual survival of alligator hatchlings. This finding suggests that TSD has adaptive advantages in alligator populations.
FUNCTIONAL ECOLOGY
(2023)
Article
Engineering, Chemical
Xueru Chen, Xue Li, Jun Wu, Cheng Fang, Jing Ding, Hui Wan, Guofeng Guan
Summary: The study prepared a high surface area isotype heptazine/triazine based carbon nitride heterojunction (HTCN-1M) using a molten salt method, which utilized H2SO4-treated melamine as precursor. The synergistic effect of the structure's built-in electric field and the abundant specific surface area led to excellent photocatalytic performance with H(2) evolution up to 5764 mu mol h(-1) g(-1), significantly higher than pure g-C3N4.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Cell Biology
Linnea C. Wethekam, Jeffrey K. Moore
Summary: By regulating gene copy number and expression levels of α- or β-tubulin genes, cells maintain an excess of α-tubulin to prevent excessive accumulation of β-tubulin, which is crucial for microtubule function and cell proliferation.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Chemistry, Physical
Mohammed A. Bajiri, Khaled Alkanad, Gubran Alnaggar, G. C. Sujay Shekar, Basheer M. Al-Maswari, Mahmood M. S. Abdullah, Amar Al-khawlani, N. K. Lokanath, B. Neppolian, H. S. Bhojya Naik
Summary: This study demonstrates the construction of an effective interphase boundary between two different morphologies of graphitic carbon nitride, leading to significant improvements in photocatalytic and sonophotocatalytic hydrogen evolution reactions. It suggests the possibility of developing intrinsic photocatalysts with different phases or morphology for efficient photocatalytic or sonophotocatalytic applications.
SURFACES AND INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Jizhou Jiang, Zhiguo Xiong, Haitao Wang, Guodong Liao, Saishuai Bai, Jing Zou, Pingxiu Wu, Peng Zhang, Xin Li
Summary: This study successfully develops a new heterojunction structure composed of sulfur-doped and sulfur-free active sites, which demonstrates high efficiency and durability in photocatalytic hydrogen evolution. The research contributes to the exploration of other carbon-based isotype S-scheme heterojunctions.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Paleontology
Gabriela Sobral, Hans-Dieter Sues, Rainer Schoch
Summary: The study presents an interesting fossil record of a reptile with unusual dentition, revealing unique anatomical features and suggesting potential evolutionary relationships with certain ancient animals. The research also indicates that tetrapods with similar tooth morphologies may have inhabited freshwater and brackish-water paleoenvironments, providing additional evidence for future morpho-functional assessments.
JOURNAL OF VERTEBRATE PALEONTOLOGY
(2021)
Article
Chemistry, Physical
Angelina Zhurenok, Dina Markovskaya, Evgeny Y. Gerasimov, Alexander S. Vokhmintsev, Ilya A. Weinstein, Igor P. Prosvirin, Svetlana Cherepanova, Andrey Bukhtiyarov, Ekaterina A. Kozlova
Summary: Two types of photocatalysts were synthesized by varying the deposition order of platinum, and their catalytic performance was tested under visible light. It was found that the ternary photocatalyst Cd1-xZnxS/1%Pt/g-C3N4 with platinum located on the g-C3N4 surface showed a higher hydrogen evolution rate compared to single-phase platinized 1%Pt/Cd1-xZnxS photocatalysts.
Article
Materials Science, Ceramics
Jing Wang, Jiajia Li, Lu Xiao, Dilnur Kurbanjan, Hong Nie, Hong Du
Summary: Efficient charge separation is achieved by porous Cd1-xZnxS nanosheets with twinned phase junctions, resulting in high photocatalytic activity for hydrogen generation. The synergy of phase junctions and porous structure improves the separation efficiency of photoelectron-hole pairs and provides more surface active sites, leading to enhanced light absorption capacity and high hydrogen evolution rate.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Chemistry, Physical
Bin Yang, Zhongwen Wang, Jiaojiao Zhao, Xiyin Sun, Rongjie Wang, Guangfu Liao, Xin Jia
Summary: A simple and template-free strategy was developed to prepare 1D/2D g-C3N4 isotype heterojunction with high separation efficiency and strong visible light absorption. The isotype heterojunction significantly improved the photocatalytic H-2 evolution activity and stability.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Multidisciplinary Sciences
Andre J. Rowe, Emily J. Rayfield
Summary: Finite element analysis (FEA) is commonly used to assess stress and strain in solid structures like bone. This study compared FEA results from CT scans and surface scans, and found that while there are similarities in overall mechanical behavior, there can be differences in exterior shape and stress distribution. Surface scans do not preserve internal geometries, resulting in lower stresses in the models compared to CT scans.
Article
Multidisciplinary Sciences
Brett W. Higgins, Andrew G. Shuparski, Karen B. Miller, Amanda M. Robinson, Louise J. McHeyzer-Williams, Michael G. McHeyzer-Williams
Summary: This study investigates the production and functions of antibody isotypes in immune processes. Through studying the molecular programs of plasma cells in mice, it is found that different cellular differentiation programs play crucial roles in long-term cellular functions during antibody affinity maturation. Additionally, in the steady state, different plasma cell differentiation programs have complementary roles in antigen clearance and immune protection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nanoscience & Nanotechnology
Chaogang Ban, Youyu Duan, Yang Wang, Jiangping Ma, Kaiwen Wang, Jiazhi Meng, Xue Liu, Cong Wang, Xiaodong Han, Guozhong Cao, Liyong Gan, Xiaoyuan Zhou
Summary: Photocatalytic conversion of CO2 to high-value products is crucial for achieving a carbon-neutral economy. Isotype heterojunctions, such as the one formed by g-C3N4, have been found to have significantly higher efficiency in spatial separation and transfer of photogenerated carriers compared to single components. This enhanced charge dynamics promotes the production of key intermediates and improves the overall reaction kinetics.
NANO-MICRO LETTERS
(2022)
Article
Paleontology
Julien Benoit, David P. Ford, Juri A. Miyamae, Irina Ruf
Summary: By comparing the maxillary canals of different species, it is suggested that Varanopidae may be more closely related to the Synapsida group, rather than the Diapsida.
ACTA PALAEONTOLOGICA POLONICA
(2021)
Article
Biochemistry & Molecular Biology
Shaoxiong Tian, Ge Yu, Huan He, Yu Zhao, Peilu Liu, Alan G. Marshall, Borries Demeler, Scott M. Stagg, Hong Li
Article
Toxicology
Michael C. Petriello, J. Anthony Brandon, Jessie Hoffman, Chunyan Wang, Himi Tripathi, Ahmed Abdel-Latif, Xiang Ye, Xiangan Li, Liping Yang, Eun Lee, Sony Soman, Jazmyne Barney, Banrida Wahlang, Bernhard Hennig, Andrew J. Morris
TOXICOLOGICAL SCIENCES
(2018)
Review
Biochemistry & Molecular Biology
Ge Yu, Yu Zhao, Hong Li
Article
Pharmacology & Pharmacy
Chunyan Wang, Michael C. Petriello, Beibei Zhu, Bernhard Hennig
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Review
Environmental Sciences
Pan Deng, Xusheng Li, Michael C. Petriello, Chunyan Wang, Andrew J. Morris, Bernhard Hennig
REVIEWS ON ENVIRONMENTAL HEALTH
(2019)
Article
Biochemistry & Molecular Biology
Pan Deng, Jessie B. Hoffman, Michael C. Petriello, Chun-Yan Wang, Xu-Sheng Li, Maria P. Kraemer, Andrew J. Morris, Bernhard Hennig
JOURNAL OF LIPID RESEARCH
(2020)
Article
Multidisciplinary Sciences
Ge Yu, Yu Zhao, Shaoxiong Tian, Jay Rai, Huan He, John Spear, Duncan Sousa, Jinbo Fan, Hong-Guo Yu, Scott M. Stagg, Hong Li
SCIENTIFIC REPORTS
(2019)
Article
Environmental Sciences
Jessie B. Hoffman, Michael C. Petriello, Andrew J. Morris, M. Abdul Mottaleb, Yipeng Sui, Changcheng Zhou, Pan Deng, Chunyan Wang, Bernhard Hennig
ENVIRONMENTAL POLLUTION
(2020)
Article
Pharmacology & Pharmacy
Pan Deng, Chunyan Wang, Banrida Wahlang, Travis Sexton, Andrew J. Morris, Bernhard Hennig
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Physiology
Wei Guo, Chaoqun Zhu, Zhiyong Yin, Yanghai Zhang, Chunyan Wang, Andrea Sanchez Walk, Ying-Hsi Lin, Timothy A. McKinsey, Kathleen C. Woulfe, Jun Ren, Herbert G. Chew
Summary: RBM20 cardiomyopathy is associated with titin isoform switching and resting Ca2+ leaking. Rbm20 knockout initially promotes larger titin isoform expression and reduces myocardial stiffness in young rats, but the full DCM phenotype takes time to develop. S107 shows therapeutic promise in restoring intracellular Ca2+ levels and cardiomyocyte contractile properties in younger Rbm20 KO rats, but may not maintain cardiac homeostasis in older rats due to multiple pathogenic mechanisms.
PHYSIOLOGICAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yanghai Zhang, Chunyan Wang, Mingming Sun, Yutong Jin, Camila Urbano Braz, Hasan Khatib, Timothy A. Hacker, Martin Liss, Michael Gotthardt, Henk Granzier, Ying Ge, Wei Guo
Summary: Arginine-serine (RS) domains play critical roles in protein-protein interaction, splicing control, and nucleocytoplasmic transport. By using mass spectrometry, we identified 16 phosphorylation sites on RS domains, including two sites located in the RSRSP stretch. Mutations on these sites affected splicing, nucleocytoplasmic transport, and protein-RNA condensates. Our study also revealed that RBM20 mutations led to cardiac pathogenesis.
Article
Cardiac & Cardiovascular Systems
Chunyan Wang, Yanghai Zhang, Mei Methawasin, Camila Urbano Braz, Jeffrey Gao-Hu, Betty Yang, Joshua Strom, Jochen Gohlke, Timothy Hacker, Hasan Khatib, Henk Granzier, Wei Guo
Summary: A study found that the RBM20 S639G mutation is associated with dilated cardiomyopathy and early death. By using a knock-in mouse model, researchers showed that this mutation promotes the formation of RBM20 granules in the sarcoplasm and leads to differential expression and splicing of genes related to arrhythmia, cardiomyopathy, and sudden death. Additionally, the knock-in mice exhibited impaired cardiac function.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu Zhao, Jay Rai, Hongguo Yu, Hong Li
Summary: This study characterized the structures and conformations of modified and pseudouridine-free ribosomes using electron cryomicroscopy. It found that pseudouridine stabilizes key functional motifs by establishing water-mediated close contacts with the phosphate backbone, while the absence of pseudouridine leads to abnormal inter-subunit movements.
Article
Biology
Yu Zhao, Jay Rai, Chong Xu, Huan He, Hong Li
Summary: AlphaFold-assisted CryoEM structure determination reveals the structure of the Bfr2-Lcp5 complex in the yeast 90S pre-ribosome. The complex interacts similarly to exosome factors Rrp6-Rrp47 and plays a role in regulating 90S transitions.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yu Zhao, Jay Rai, Hong Li
Summary: Pseudouridine is vital to the central dogma as it is enriched in ribosomal, spliceosomal, transfer, and messenger RNA. However, the impact of pseudouridine on the molecular apparatus, such as the ribosome, remains unclear due to a lack of structures without this modification. This study investigated the translation of a hypopseudouridylated ribosome initiated by the internal ribosome entry site (IRES) elements, revealing the loss of pseudouridine-mediated interactions and the link between functional defects and modification loss.