Review
Pharmacology & Pharmacy
Anas Ahmad, Mohammad Imran, Nisha Sharma
Summary: The assessment of human and environmental risks of nanoparticulate material is crucial and requires the development of scientific tools and techniques. Challenges exist in toxicology assessment and regulatory guidance for nanocarriers. Nanotoxicology plays a significant role in pharmaceutical drug development and commercialization potential.
Review
Chemistry, Multidisciplinary
Catia Domingues, Ana Santos, Carmen Alvarez-Lorenzo, Angel Concheiro, Ivana Jarak, Francisco Veiga, Isabel Barbosa, Marilia Dourado, Ana Figueiras
Summary: Worldwide development and application of nanotechnology have led to significant scientific advancements. It is important to balance the high expectations and concerns associated with this field. Nanomedicine, a specific arm of nanotechnology, focuses on the diagnosis, treatment, and monitoring of various diseases. However, the concept of nanotoxicology has also emerged as a crucial aspect of nanomedicine. More research is needed to identify potential adverse effects and ensure the safety of nanomedicines.
Article
Biophysics
Edvinas Navakauskas, Gediminas Niaura, Simona Strazdaite
Summary: We used vibrational sum-frequency generation spectroscopy to study the effect of isotopic substitution on the properties of a DPPC monolayer. We found that deuteration of the choline group significantly impacted the monolayer properties, while deuteration of the alkyl chains did not have any effect. Deuteration of the choline group also affected the hydration of the phosphate group.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biotechnology & Applied Microbiology
Xue Bai, Jiali Wang, Qingxin Mu, Gaoxing Su
Summary: Understanding the interactions between engineered nanoparticles (ENPs) and biological systems is crucial for evaluating their safety and developing nanomedicine. Protein corona (PC) formation plays a key role in altering the properties and behaviors of ENPs, impacting their absorption, circulation, distribution, metabolism, and toxicity. In vivo studies on PC formation have shown differences in protein composition and structure compared to in vitro studies, highlighting the importance of considering real-life scenarios in nanomedical research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Developmental Biology
Leonie Aengenheister, Rodolfo R. Favaro, Diana M. Morales-Prieto, Lea A. Furer, Michael Gruber, Christian Wadsack, Udo R. Markert, Tina Buerki-Thurnherr
Summary: Increasing human exposure to nanoparticles raises concerns for public health, especially vulnerable risk groups like pregnant women and their developing fetuses, but nanomedicine offers promise for pregnancy treatment. Studies on ex vivo human placental perfusion of NPs reveal characteristics such as size and surface modifications influence placental uptake and transfer significantly, highlighting the need for relevant controls in future studies. Ex vivo placental perfusion model shows potential in revealing insights on NP effects on placental tissue functionality, impacting maternal-fetal health indirectly.
Review
Biochemistry & Molecular Biology
Nhung H. A. Nguyen, Priscila Falagan-Lotsch
Summary: Nanotechnology has great potential in the biomedical field, but the limited understanding of nano-bio interactions has hindered their use and commercialization. Understanding these interactions is crucial in nanotoxicology and nanomedicine to develop safe nanomaterials and improve the efficacy of nanomedicines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Engineering, Chemical
Jesus Roberto Vargas-Ortiz, Carmen Gonzalez, Karen Esquivel
Summary: This review discusses the role, physicochemical properties, potential applications, and toxicological effects of magnetic nanoparticles (MNPs) in complex biological systems. MNPs have been widely used in various industries, leading to increased interactions with biological organisms. However, the full impact of these particles on complex biological systems and the toxicology aspects of their biomedical applications remain unclear, with mixed and inconclusive results. A consolidative framework that considers the physicochemical properties and potential risks of MNPs is necessary for their future manageable applications.
Article
Biophysics
Caio Vaz Rimoli, Rafael de Oliveira Pedro, Paulo B. Miranda
Summary: The study investigates the interactions of chitosan and poly(allylamine) hydrochloride on phospholipid membrane models, revealing different effects on different types of membranes, highlighting the importance of molecular structure and interactions for bioactivity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Olesja Bondarenko, Monika Mortimer, Anne Kahru, Neus Feliu, Ibrahim Javed, Aleksandr Kakinen, Sijie Lin, Tian Xia, Yang Song, Thomas P. Davis, Iseult Lynch, Wolfgang J. Parak, David Tai Leong, Pu Chun Ke, Chunying Chen, Yuliang Zhao
Summary: Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology that focus on nano-bio interface, with shared goals and challenges. In recent years, the relationship between the two fields has become closer, and their joint development can bring greater benefits to human health and environmental safety.
Article
Biochemistry & Molecular Biology
Emilia Piosik, Marta Ziegler-Borowska, Dorota Chelminiak-Dudkiewicz, Tomasz Martynski
Summary: The research investigates the adsorption process of magnetite nanoparticles functionalized with aminated chitosan into cell membrane models. The study demonstrates a membrane model composition-dependent regulation of phospholipid-nanoparticle interactions, with stronger adsorption of Fe3O4-AChit nanoparticles into negatively charged DPPG monolayers likely due to electrostatic attraction. Additionally, differences in adsorption strength of the nanoparticles into Langmuir films formed by phosphatidylcholines were observed, with easier adsorption into more loosely packed POPC monolayers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Xuexin Li, Weiyuan Li, Mina Wang, Zehuan Liao
Summary: Nanoparticles have emerged as a novel approach in cancer diagnosis and treatment, showing great potential in medical applications. However, more research is needed to improve their toxicity and efficacy for clinical use.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Toxicology
Wei-Chun Chou, Yi-Hsien Cheng, Jim E. Riviere, Nancy A. Monteiro-Riviere, Wolfgang G. Kreyling, Zhoumeng Lin
Summary: This study suggests that the traditional route-to-route extrapolation approaches for PBPK modeling of small molecules are not applicable to NPs. Therefore, multi-route PBPK models for NPs should be developed using route-specific data. The PBPK model using the new approach showed superior performance compared to the traditional approach. In addition, QSAR-based multivariate linear regressions were established to predict key biodistribution parameters based on the physicochemical properties of AuNPs.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Oncology
Nuria Lafuente-Gomez, Paula Milan-Rois, David Garcia-Soriano, Yurena Luengo, Marco Cordani, Hernan Alarcon-Iniesta, Gorka Salas, Alvaro Somoza
Summary: The study introduced a smart gemcitabine delivery system based on magnetic nanoparticles, enabling selective release in pancreatic cancer cells via disulfide bonds. The modified nanoparticles showed promising potential for biomedical applications by reducing drug toxicity in non-cancerous cells, enhancing internalization, and synergistic cytotoxic effects when combined with magnetic hyperthermia.
Article
Biochemistry & Molecular Biology
Emilia Piosik, Aleksandra Zaryczniak, Kinga Mylkie, Marta Ziegler-Borowska
Summary: Understanding the interactions between magnetite nanoparticles and phospholipids in cell membranes is crucial for safe medical applications. Surface coating of nanoparticles plays a key role, with aminated starch improving drug binding and reducing membrane disruption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Analytical
Marcela Tavares Luiz, Jessyca Aparecida Paes Dutra, Leonardo Delello Di Filippo, Alberto Gomes Tavares Junior, Larissa Bueno Tofani, Juliana Maldonado Marchetti, Marlus Chorilli
Summary: Epirubicin is a chemotherapeutic agent used for treating tumors, and its delivery in nanosystems can enhance safety and efficacy. Spectrophotometric, spectrofluorimetric, and chromatographic methods are commonly employed for analyzing and characterizing these nanosystems.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Hyunsik Hong, Sunhong Min, Sagang Koo, Yunjung Lee, Jinho Yoon, Woo Young Jang, Nayeon Kang, Ramar Thangam, Hyojun Choi, Hee Joon Jung, Seong-Beom Han, Qiang Wei, Seung-Ho Yu, Dong-Hwee Kim, Ramasamy Paulmurugan, Woong Kyo Jeong, Ki-Bum Lee, Taeghwan Hyeon, Dokyoon Kim, Heemin Kang
Summary: This study investigates the modulation of stem cell differentiation in the microenvironment using nanoassembly-based magnetic screens. Different sizes of screens can affect the adhesion, mechanotransduction, and differentiation of stem cells by adjusting nanogaps. This regulation mechanism is shown to be effective in vivo, demonstrating the potential for diverse modalities of unscreening RGDs to modulate stem cell differentiation for tissue repair.
ADVANCED MATERIALS
(2022)
Article
Polymer Science
Thiers M. Uehara, Fernanda L. Migliorini, Murilo H. M. Facure, Nicolau B. Palma Filho, Paulo B. Miranda, Valtencir Zucolotto, Daniel S. Correa
Summary: The study investigates the application of graphene oxide (GO) in medical devices, focusing on its interactions with liver cancer cells on different scaffold platforms. Spectroscopic and electrochemical analysis reveal the characteristics of GO-cell interactions, providing insights for regenerative medicine research.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Engineering, Biomedical
Edson J. Comparetti, Paula M. P. Lins, Joao Quitiba, Valtencir Zucolotto
Summary: In this study, nanocarriers were used to transport siRNA into cancer cells and leukocytes to modulate the activity of tumor microenvironment cells. The results showed that the nanostructures were stable and could reduce the expression of CD47 and PD-L1 on cancer cells, and switch APC activity for an anti-tumor response.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Marine & Freshwater Biology
Priscila Rodrigues Siqueira, Jaqueline Perola Souza, Bianca Martins Estevao, Wanessa Fernanda Altei, Talita Laurie Lustosa Carmo, Fabricio Aparecido Santos, Heloisa Sobreiro Selistre Araujo, Valtecir Zucolotto, Marisa Narciso Fernandes
Summary: This study investigated the effects of graphene oxide (GO) and reduced graphene oxide (rGO) on zebrafish hepatocytes using in vitro assays. The results showed that the internalization of GO increased with increasing concentrations, while rGO had stronger interaction with the cell membrane due to its hydrophobic characteristic. After 72 hours of exposure, both GO and rGO showed harmful effects on the cells, but with different mechanisms of toxicity.
AQUATIC TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Letao Yang, Christopher Rathnam, Takuya Hidaka, Yannan Hou, Brandon Conklin, Ganesh N. Pandian, Hiroshi Sugiyama, Ki-Bum Lee
Summary: The study highlights the development of a nanoparticle-based synthetic mitochondrial transcription regulator (MitoScript) for controlling mitochondrial DNA transcription. MitoScript demonstrates great colloidal stability, biocompatibility, efficient cell uptake, and selective mitochondria targeting. It effectively downregulated the expression of the ND6 gene, which impacted the cell's redox status, resulting in increased ROS generation. This technology could contribute to understanding mitochondrial disorders and developing treatments for mitochondrial diseases.
Article
Chemistry, Multidisciplinary
Brian M. Conley, Letao Yang, Basanta Bhujel, Jeffrey Luo, Inbo Han, Ki-Bum Lee
Summary: We developed a dynamic and multifunctional nanohybrid peptide hydrogel that can overcome the heterogeneous pro-inflammatory and inhibitory extracellular matrix microenvironment, enabling robust repair of severely wounded fibrocartilaginous tissues.
Article
Chemistry, Multidisciplinary
Letao Yang, Basanta Bhujel, Yannan Hou, Jeffrey Luo, Seong Bae An, Inbo Han, Ki-Bum Lee
Summary: Degeneration of fibrocartilaginous tissues is often associated with complex pro-inflammatory factors, including reactive oxygen species (ROS), cell-free nucleic acids (cf-NAs), and epigenetic changes in immune cells. A self-therapeutic and epigenetic modulator-encapsulated hybrid protein nanoscaffold shows promise for restoring dysregulated inflammatory signaling and treating degenerative fibrocartilaginous diseases, such as disc injuries. The nanoscaffold exhibits inflammatory stimuli-responsive drug release, disc-mimetic stiffness, and excellent biodegradability, along with the ability to scavenge ROS and cf-NAs, reducing inflammation and promoting tissue regeneration.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Sarah Nevins, Callan D. McLoughlin, Alfredo Oliveros, Joshua B. Stein, Mohammad Abdur Rashid, Yannan Hou, Mi-Hyeon Jang, Ki-Bum Lee
Summary: Nanotechnology offers a promising approach for targeted drug delivery, improving the effectiveness and safety of therapeutics. Nanomaterials developed for selective targeting of cancers can potentially treat off-target effects caused by chemotherapy. Chemotherapy-induced neurotoxicity, neuropathy, and cardiomyopathy are common side effects that impact the quality of life for breast and ovarian cancer survivors. Nanoparticles have the potential to enhance therapeutic efficacy and reduce side effects, but more research is needed to develop interventions for women cancer survivors.
Article
Engineering, Biomedical
Jeffrey Luo, Anjani Darai, Thanapat Pongkulapa, Brian Conley, Letao Yang, Inbo Han, Ki-Bum Lee
Summary: Intervertebral disc degeneration is a common cause of back pain and can lead to more serious conditions such as disc herniation and spinal stenosis. Traditional growth factor therapies have limited effectiveness in completely regenerating degenerated discs, thus there is a need for bioscaffolds. A new injectable bioorthogonal hydrogel, called BIOGEL, was developed using tetrazine-norbornene bioorthogonal ligation combined with gelatin. This BIOGEL showed promising results in promoting tissue repair and functional recovery in rat models of IVD degeneration.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Analytical
Jairo Pinto de Oliveira, Francisco Burgos-Florez, Isabella Sampaio, Pedro Villalba, Valtencir Zucolotto
Summary: In this study, a label-free impedimetric immunosensor was developed to detect OTA in coffee. The biosensor showed high selectivity and was not affected by matrix interference in coffee samples. It has the advantages of small sample volume, short analysis time, and potential miniaturization.
Editorial Material
Clinical Neurology
Jeffrey Luo, Joshua B. Stein, Ki-Bum Lee
Article
Materials Science, Biomaterials
Luana Corsi Antonio, Lais Ribovski, Paula Maria Pincela Lins, Valtencir Zucolotto
Summary: Polymeric nanocarriers are effective drug delivery tools, but their toxic effects on cellular processes and interactions with cells still need further evaluation. This study assessed the interaction of nanocarriers prepared with different concentrations of Dex with myocardial cells, breast adenocarcinoma cells, and macrophages. The results showed that Dex concentration affected the uptake of nanocarriers and the formation of protein corona, and different carriers had varying mechanisms of cellular damage.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Nanoscience & Nanotechnology
Renata Rank Miranda, Natalia Noronha Ferreira, Edmarcia Elisa de Souza, Paula Maria Pincela Lins, Leonardo Miziara Barboza Ferreira, Arne Kruger, Valeria Maria de Oliveira Cardoso, Edison Luiz Durigon, Carsten Wrenger, Valtencir Zucolotto
Summary: This study explores a drug repurposing strategy using nanotechnology to develop a therapy for COVID-19 treatment. By encapsulating the drug in nanoparticles, the toxicity of the drug is reduced while its antiviral activity is enhanced. This approach shows great potential as a new strategy in the fight against COVID-19.
ACS APPLIED BIO MATERIALS
(2022)
Review
Chemistry, Physical
Sara Shakibania, Mehrdad Khakbiz, Cemile Kilic Bektas, Lida Ghazanfari, Milad Tavakoli Banizi, Ki-Bum Lee
Summary: Early diagnosis of diseases is crucial in selecting appropriate treatments, preventing problems, and stopping the spread of diseases. Additive manufacturing (AM) or 3D printing technology has been widely used in biomedical applications, providing highly precise and economical diagnostic tools with complex geometries.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2022)
Article
Chemistry, Physical
Ali Akbar Ashkarran, Atiyeh Hosseini, Reza Loloee, George Perry, Ki-Bum Lee, Mikael Lund, Mohammad Reza Ejtehadi, Morteza Mahmoudi
Summary: We investigated the charge transport characteristics of self-assembled monolayers (SAMs) of short tau peptides using electron tunneling rates and quantum mechanical simulation. Our findings showed that the conformation and phosphorylation of short peptides can significantly affect their electron tunneling current and energy levels.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
