期刊
ACS APPLIED MATERIALS & INTERFACES
卷 5, 期 1, 页码 213-219出版社
AMER CHEMICAL SOC
DOI: 10.1021/am302589g
关键词
conjugated polymers; self-assembly; core-shell nanoparticles; fluorescence; gold nanoflowers; cellular imaging
资金
- National Natural Science Foundation of China [20904003, 90923015]
- General Financial Grant from the China Postdoctoral Science Foundation [2011M500235]
- State Key Lab for Advanced Metals and Materials [2012-ZD05]
- Fundamental Research Funds for the Central Universities of China [FRF-TP-09-006A, FRF-TP-09-011B]
- Program for New Century Excellent Talents in University of Ministry of Education of China [NCET-11-0576]
In the present work, a facile one-pot method is designed to fabricate a core shell fluorescent nanoparticle (NP) for cellular imaging based on a new cationic conjugated polymer, poly[9,9'-bis(6,6'-(N,N,N-trimethylaminium)-fluorene-2,7-ylenevinylene-co-alt-2,5-dicyano-1,4-phenylene] (PFVCN). Gold nanoflowers (AuNFs) are prepared by a seedless method, in which a gelatin layer formed through a sol-gel phase transition is deposited on the surface of each AuNF. The cationic PFVCN self-assembles onto the negative surface of the resultant (AuNF@Gelatin NPs) driven by electrostatic attraction. An obvious enhancement of fluorescence intensity is observed. The AuNF@Gelatin/PFVCN NPs exhibit excellent c-ytocompatibility, and their cellular imaging ability is demonstrated when cocultured with HeLa cells. AuNF@Gelatin/PFVCN hybrid NPs are expected to be a desirable material in the field of cellular imaging and biosensing.
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