Article
Immunology
Moon H. Nahm, Jigui Yu, Juan J. Calix, Feroze Ganaie
Summary: Reports conflict on which lectin-microbial ligand interactions trigger a protective response from the lectin pathway (LP) of complement. In this study, researchers demonstrate the binding of human lectin ficolin-2 to the capsule polysaccharide of Streptococcus pneumoniae serotype 11A, which leads to complement deposition and phagocytosis of the bacteria. The study also suggests that the gene wcjE plays a crucial role in ficolin-2's ligand expression and bacterial killing. The findings highlight the importance of glycopolymer-specific evaluation of LP's impact.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhongliang Wang, Xueru Liang, Guiying Li, Bai Liufu, Kaiqi Lin, Jinfeng Li, Jing Wang, Bei Wang
Summary: The pearl oyster pf-C3 gene was characterized, showing similarities with homologs in terms of structural features and functional domains. Expression of pf-C3 mRNA was detected in various tissues, with significant induction in hemocytes following Vibrio alginolyticus challenge. Knockdown of pf-C3 resulted in reduced phagocytosis activity in vitro, indicating a potential role in immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Anneloes van Duijn, Sjoerd H. Van der Burg, Ferenc A. Scheeren
Summary: This article focuses on the interactions between myeloid immune cells and anti-tumor immune responses in the tumor microenvironment. Blocking the CD47/SIRP alpha axis can enhance adaptive immune response. The potential therapeutic role of CD47/SIRP alpha axis is discussed in tumors with acquired resistance to classic immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Matthew R. Woeste, Rejeena Shrestha, Anne E. Geller, Shu Li, Diego Montoya-Durango, Chuanlin Ding, Xiaoling Hu, Hong Li, Aaron Puckett, Robert A. Mitchell, Traci Hayat, Min Tan, Yan Li, Kelly M. McMasters, Robert C. G. Martin, Jun Yan
Summary: This study investigates the combination therapy of IRE and beta-glucan in the treatment of pancreatic cancer, and finds that this combination can enhance immune response, reduce tumor burden, and prolong survival in patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Microbiology
Elisabet Bjanes, Victor Nizet
Summary: The complement system is a crucial defense mechanism in immune responses against various pathogens, playing multiple roles beyond direct membrane lysis. While Gram-positive bacteria possess inherent resistance to complement-mediated killing, complement can still flag and destroy these bacteria through alternative mechanisms, demonstrating its versatility in the immune defense.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2021)
Article
Microbiology
Carlos Henrique D. Barbosa, Louis Lantier, Joseph Reynolds, Jinyong Wang, Fabio Re
Summary: Immunization with Ft LPS triggers production of IL-25, which promotes activation and differentiation of B1 cells into IgM secreting cells through stimulation of IL-5 release by ILC2. This IL-25-ILC2-IL-5 axis represents a potential novel strategy to improve vaccination against T-independent bacterial antigens.
Article
Biology
S. Marina Casalino-Matsuda, Sergejs Berdnikovs, Naizhen Wang, Aisha Nair, Khalilah L. Gates, Greg J. Beitel, Peter H. S. Sporn
Summary: Studies have shown that hypercapnia inhibits select innate immune genes and suppresses host defence against bacterial and viral pneumonia. Under hypercapnia conditions, global gene transcription in human and mouse macrophages is selectively down-regulated for genes associated with innate immunity, antiviral response, and inflammation, while genes related to mitosis and DNA repair are upregulated. These changes in gene expression may partially explain the high mortality in patients with severe lung disease and hypercapnia.
Article
Biochemistry & Molecular Biology
Yuan Liu, Ao Zhang, Na Guo, Qiang Hao, Fuhua Li
Summary: In this study, a ficolin gene Ptficolin was characterized from the swimming crab Portunus trituberculatus. Ptficolin showed higher expression in stomach and hepatopancreas, and could recognize and eliminate invading pathogens, playing an important role in hemolymph coagulation in crabs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Cell Biology
Xuehua Xu, Miao Pan, Tian Jin
Summary: The discovery of how phagocytes effectively find and kill pathogens through chemotaxis and phagocytosis sheds light on the evolutionarily conserved mechanisms underlying these processes in mammals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Edna Ayerim Mandujano-Tinoco, Eliya Sultan, Aner Ottolenghi, Orly Gershoni-Yahalom, Benyamin Rosental
Summary: The evolution of the immune system is aimed at protecting organisms from infections and providing regenerative capacities and tissue maintenance. Despite the diverse range of effector cells, common features and interesting convergent mechanisms can be observed across different animals. The review explores the evolution of phagocytic and cytotoxic immune lineages, highlighting the diverse function plasticity within evolved immune effector cells.
Article
Environmental Sciences
Tyler E. Harman, Briana Hauff-Salas, Joshua A. Haslun, James M. Cervino, Kevin B. Strychar
Summary: This study analyzes the photosynthetic efficiency of Porites astreoides corals in two different reef sites in the lower Florida Keys. The results show that the photosynthetic efficiency of corals is influenced by the specific characteristics of each site, with the Acer24 reef site experiencing a significant decrease in photosynthetic efficiency compared to the Birthday reef site. Additionally, exposure to an immune stimulant (LPS) leads to a significant increase in photosynthetic efficiency.
Article
Biochemistry & Molecular Biology
Michikazu Tanio
Summary: C-reactive protein (CRP) and M-ficolin are pattern recognition proteins of the innate immune system. They can reversibly coaggregate in a calcium-dependent manner, potentially playing a role in bacteria trapping and arterial disease development.
MOLECULAR IMMUNOLOGY
(2022)
Article
Clinical Neurology
Che-Feng Chang, Brittany A. Goods, Michael H. Askenase, Hannah E. Beatty, Artem Osherov, Jonathan H. DeLong, Matthew D. Hammond, Jordan Massey, Margaret Landreneau, J. Christopher Love, Lauren H. Sansing
Summary: Our study shows that microglia and MDMs have distinct functional properties in the brain after ICH, with MDMs exhibiting higher phagocytic activity, erythrophagocytosis, and antigen-presenting capabilities compared to microglia. This suggests that the different origins of microglia and MDMs lead to divergent responses and functions in the inflamed brain following ICH.
Review
Immunology
Chiara Agostinis, Andrea Balduit, Alessandro Mangogna, Gabriella Zito, Federico Romano, Giuseppe Ricci, Uday Kishore, Roberta Bulla
Summary: Endometriosis is a chronic disease characterized by the presence and proliferation of endometrial tissues outside the uterus, with symptoms depending on the location of involvement. The risk of developing endometriosis is influenced by complex interactions between genetic, immunological, hormonal, and environmental factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Raffaella Parente, Valentina Possetti, Marco Erreni, Francesca D'Autilia, Barbara Bottazzi, Cecilia Garlanda, Alberto Mantovani, Antonio Inforzato, Andrea Doni
Summary: The ubiquitous mold Aspergillus fumigatus is the major cause of invasive aspergillosis, requiring coordinated action of cellular and humoral components of the innate immune system for effective disposal. The complement system and pentraxins form an integrated system with interactions, synergy, and regulation, playing a pivotal role in mounting antifungal immunity. Proteins like PTX3 and SAP target A. fumigatus through complement-dependent pathways, utilising different mechanisms of complement activation and receptor-mediated phagocytosis, adding complexity to the immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gabriela Gajek, Anna S. Swierzko, Maciej Cedzynski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Oncology
Maciej Cedzynski, Anna S. swierzko
Article
Biochemistry & Molecular Biology
Katarzyna Sobierajska, Wojciech M. Ciszewski, Ewa Macierzynska-Piotrowska, Wanda Klopocka, Patrycja Przygodzka, Magdalena Karakula, Karolina Pestka, Marta E. Wawro, Jolanta Niewiarowska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Tomasz K. Gozdziewicz, Anna Maciejewska, Alona Tsybulska, Czeslaw Lugowski, Jolanta Lukasiewicz
Summary: Enterobacterial common antigen (ECA) is a conserved antigen expressed by enterobacteria in different forms. This study used various techniques to purify, fractionate, and analyze the structure of ECA, revealing the complexity of ECA derived from LPS supernatants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Szymczak-Kulus, Sascha Weidler, Anna Bereznicka, Krzysztof Mikolajczyk, Radoslaw Kaczmarek, Bartosz Bednarz, Tao Zhang, Anna Urbaniak, Mariusz Olczak, Enoch Y. Park, Edyta Majorczyk, Katarzyna Kapczynska, Jolanta Lukasiewicz, Manfred Wuhrer, Carlo Unverzagt, Marcin Czerwinski
Summary: Human Gb3/CD77 synthase is a promiscuous glycosyltransferase that can produce various glycosphingolipids recognized by Shiga toxins. Experimental evidence shows that this enzyme can synthesize P1 glycotope on N-glycans and glycoproteins, allowing Shiga toxins to enter and kill cells. The results suggest a new mechanism for Shiga toxin pathology beyond canonical GSL receptors.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Oncology
Izabela Papiewska-Pajak, Patrycja Przygodzka, Damian Krzyzanowski, Kamila Soboska, Izabela Szulc-Kielbik, Olga Stasikowska-Kanicka, Joanna Boncela, Malgorzata Wagrowska-Danilewicz, M. Anna Kowalska
Summary: Understanding the role of extracellular vesicles (EVs) in cancer progression is crucial, as EVs released from cells with migratory properties contain different factors compared to EVs from original tumor cells. These EVs could potentially serve as biomarkers to denote the stage of colorectal cancer (CRC) and be targeted to prevent cancer progression.
Article
Oncology
Patrycja Przygodzka, Ewelina Sochacka, Kamila Soboska, Marcin Pacholczyk, Izabela Papiewska-Pajak, Tomasz Przygodzki, Przemyslaw Plocinski, Steven Ballet, An De Prins, Joanna Boncela
Summary: The study found elevated expression of NMU and NMUR2 in CRC tissue samples and variable expression in CRC cell lines. It was shown for the first time that NMUR2 activation induces signaling in CRC cells, and NMU increases motility and invasiveness in NMUR2-positive CRC cells, as well as promoting prometastatic integrin receptor subunit expression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Marta Kaszowska, Grazyna Majkowska-Skrobek, Pawel Markwitz, Cedric Lood, Wojciech Jachymek, Anna Maciejewska, Jolanta Lukasiewicz, Zuzanna Drulis-Kawa
Summary: This study investigated the genetic and phenotypic characteristics of resistance to phage-borne polysaccharide-degrading enzymes in Klebsiella pneumoniae, leading to the loss of capsule and increased susceptibility to the innate immune response. The research discovered that emerging resistance to the antivirulence agent resulted in beneficial consequences by sensitizing the bacteria to phagocytosis and enhancing adherence and internalization to human lung epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Tim Rollenske, Sophie Burkhalter, Lukas Muerner, Stephan von Gunten, Jolanta Lukasiewicz, Hedda Wardemann, Andrew J. Macpherson
Summary: In this study, recombinant dimeric monoclonal IgAs were used to map the intestinal plasma cell response to microbial colonization in mice, revealing distinct effects on microbial function and metabolism depending on the antigen specificity of the dimeric mIgAs. Even when targeting the same microbial antigen, different IgA epitope specificities led to varied microbial metabolic changes.
Article
Immunology
Anna S. Swierzko, Dariusz Jarych, Gabriela Gajek, Karolina Chojnacka, Paulina Kobiela, Maja Kufelnicka-Babout, Mateusz Michalski, Katarzyna Sobczuk, Agnieszka Szala-Pozdziej, Misao Matsushita, Jan Mazela, Iwona Domzalska-Popadiuk, David C. Kilpatrick, Jaroslaw Kalinka, Hideharu Sekine, Maciej Cedzynski
Summary: The study identified FCN2 gene 3'UTR polymorphisms associated with ficolin-2 expression and perinatal complications in preterm neonates, with some polymorphisms showing linkage disequilibrium and influence on serum ficolin-2 concentration. These findings indicate a potential genetic basis for susceptibility to infections and birthweight in preterm neonates.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Maciej Cedzynski, Anna S. Swierzko
Summary: The complement system is a crucial branch of the innate immune response that can be activated through three distinct pathways. It plays a role in maintaining/restoring homeostasis, interacting with cellular and acquired immunity components. The cross-talk between the complement system and other enzyme-dependent cascades enhances its defensive capabilities, but excessive or chronic activation may be harmful.
Article
Biochemistry & Molecular Biology
Anna Maciejewska, Czeslaw Lugowski, Jolanta Lukasiewicz
Summary: Streptococcus gallolyticus subspecies gallolyticus is a facultative pathogen associated with bacteraemia, infective endocarditis, and sepsis that has been linked with colorectal cancer. Its major sugar antigen, the exopolysaccharide (EPS), is a potential virulence factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Katarzyna Kasperkiewicz, Anna S. Swierzko, Mateusz Michalski, Lukasz Eppa, Mikael Skurnik, Zbigniew Zuber, Maciej Cedzynski
Summary: This study found that chemotype-specific antibodies to Yersinia enterocolitica O:3 LPS were present in synovial fluids from patients with arthritis, with high titers of antibodies specifically recognizing the Kdo-lipid A region. Western blot analysis showed antibodies reacting with fast-migrating LPS fractions and enterobacterial common antigen (ECA). Furthermore, in vitro experiments confirmed that Yersinia LPS processing leads to the exposure of its core region and enhanced potency of complement lectin pathway activation.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Patrycja Przygodzka, Kamila Soboska, Ewelina Sochacka, Marcin Pacholczyk, Marcin Braun, Hassan Kassassir, Izabela Papiewska-Pajak, Michal Kielbik, Joanna Boncela
Summary: The study revealed that NMU levels are elevated in human CRC compared to normal tissue, with high NMUR1 expression correlating with shorter overall survival in CRC patients. NMUR1 expression was identified in macrophages, endothelial cells, platelets, and platelet microparticles, with NMU-stimulated macrophages increasing the migratory potential of CRC cells. Additionally, NMU activation induced pro-metastatic phenotypes in macrophages and endothelial cells, changing their secretome.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Immunology
Anna Krakowska, Maciej Cedzynski, Agnieszka Wosiak, Rafal Swiechowski, Adrian Krygier, Marcin Tkaczyk, Krzysztof Zeman
Summary: The study found that TLR2 and TLR4 gene polymorphisms are associated with children suffering from urinary tract infections (UTI), while urine neutrophil gelatinase-associated lipocalin (NGAL) concentration can reflect the degree of kidney tissue injury in children with urinary tract malformations.
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
