期刊
ACS APPLIED MATERIALS & INTERFACES
卷 4, 期 4, 页码 2033-2040出版社
AMER CHEMICAL SOC
DOI: 10.1021/am300008x
关键词
drug carrier; magnetic resonance imaging; nanoparticle; photocytotoxicity; porosity
资金
- RGC-GRF [401709]
- UGC [AoE/P-03/08]
- NSFC [11102202]
Novel high magnetization microspheres with porous gamma-Fe2O3 core and porous SiO2 shell were synthesized using a templating method, whereas the size of the magnetic core and the thickness of the porous shell can be controlled by tuning the experimental parameters. By way of an example, as-prepared gamma-Fe2O3@meso-SiO2 microspheres (170 nm) display excellent water-dispersity and show photonic characteristics under externally applied a magnetic field. The magnetic property of the gamma-Fe2O3 porous core enables the microspheres to be used as a contrast agent in magnetic resonance imaging with a high r(2) (76.5 s(-1) mM(-1) Fe) relaxivity. The biocompatible composites possess a large BET surface area (222.3 m(2)/g), demonstrating that they can be used as a bifunctional agent for both MM and drug carrier. Because of the high substrate loading of the magnetic, dual-porous materials, only a low dosage of the substrate will be acquired for potential practical applications. Hydrophobic zinc(II) phthalocyanine (ZnPC) photosensitizing molecules have been encapsulated into the dual-porous microspheres to form gamma-Fe2O3@meso-SiO2-ZnPC microspheres. Biosafety, cellular uptake in HT29 cells, and in vitro MRI of these nanoparticles have been demonstrated. Photocytotoxicity (lambda > 610 nm) of the HT29 cells uptaken with gamma-Fe2O3@meso-SiO2-ZnPC microspheres has been demonstrated for 20 min illumination.
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