期刊
ACS APPLIED MATERIALS & INTERFACES
卷 3, 期 12, 页码 4831-4836出版社
AMER CHEMICAL SOC
DOI: 10.1021/am201320a
关键词
drug delivery; controlled release; plasma polymerization; n-heptylamine; levofloxacin; Staphylococcus aureus; biofilm; antibacterial surface
资金
- Australian Government under NHMRC [1000737]
- Australian Research Council [FT100100292]
- Australian Research Council [FT100100292] Funding Source: Australian Research Council
Targeted delivery and controlled local release of drugs has a number of advantages over conventional systemic drug delivery approaches. Novel platforms for local delivery from solid drug carriers are needed to satisfy the requirements of various medical applications, in particular for the incorporation and release of hydrophilic drugs from a solid carrier material. We have utilized the plasma polymerization of n-heptylamine for the generation of two thin coated layers that serve two distinct purposes. First, an n-heptylamine plasma polymer layer is applied onto the surface of the solid carrier material in order to facilitate spreading of the drug, which is applied by solvent casting; levofloxacin in ethanol was used for this study. A second n-heptylarnine plasma polymer coating then serves as a thin barrier coating to control the release. We show that the rate of release can be adjusted via the thickness of the plasma polymer overlayer. We also show that this modality of controlled release of levofloxacin completely inhibits Methicillin-resistant Staphylococcus aureus (MRSA) colonization and bioffirn formation on and near the coated biomaterial surface.
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