期刊
ACS APPLIED MATERIALS & INTERFACES
卷 1, 期 10, 页码 2400-2407出版社
AMER CHEMICAL SOC
DOI: 10.1021/am9005463
关键词
complement activation; protein adsorption; poly(vinyl alcohol); dextran
资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan [21240051]
- Kyoto City Collaboration of Regional Entities for the Advancement of Technological Excellence, JST, Japan
- Grants-in-Aid for Scientific Research [21240051] Funding Source: KAKEN
Hydrogels of polymers carrying Surface hydroxyl groups strongly activate the complement system through the alternative pathway, although it has also been reported that solutions of polymers do not. To address these curious, inconsistent results. we examined the effect of polymer states, either immobilized on a surface or soluble in serum, on the complement activation using a surface plasmon resonance apparatus and enzyme-linked immunosorbent assay We clearly showed that dextran- and poly(vinyl alcohol)-immobilized surfaces strongly activated the complement system but that soluble polymers could not, even when the amounts of the soluble polymers added to serum were 4-2000 dines higher than those on the polymer-immobilized surfaces
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