期刊
ACADEMIC RADIOLOGY
卷 19, 期 1, 页码 26-34出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.acra.2011.09.008
关键词
Metachromatic leukodystrophy; demyelination load; semiautomatic segmentation; magnetic resonance imaging; lesion load
资金
- IZKF-Promotionskolleg, Medical Faculty, University of Tubingen [PK2011-6]
- German Federal Ministry of Education and Research
- Shire plc
- German Research Council DFG [WI3630/1-1]
Rationale and Objectives: Metachromatic leukodystrophy is a lysosomal storage disorder leading to progressive demyelination of brain white matter. This is sensitively detected using magnetic resonance imaging. The volume of demyelination, the demyelination load, could serve as a useful parameter for assessing both the natural course of the disease and treatment effects. The aim of this study was to develop and validate a semiautomated approach for determining the demyelination load to achieve reliable and time-efficient segmentation results. Materials and Methods: The demyelination load was determined in 77 magnetic resonance imaging data sets from 35 patients both manually and semiautomatically. For manual segmentation, regarded as the gold standard, the software ITK-Snap was used. For semiautomatic segmentation, a new algorithm called Clusterize was developed and implemented in MATLAB, consisting of automatic iterative region growing followed by the interactive selection of clusters. Results were compared in terms of the obtained volumes, spatial overlap, and time taken to conduct the segmentation. Results: Performance of the semiautomatic algorithm was excellent, with the volumes generated by the new algorithm showing good agreement with the ones generated by the gold standard (93.4 +/- 45.5 vs 96.1 +/- 49.0 mL, P = NS) with high spatial overlap (Dice's similarity coefficient = 0.7861 +/- 0.0697). The semiautomatic algorithm was significantly faster than the gold standard (8.2 vs 27.0 min, P < .001). Intrarater and interrater reliability determined high reproducibility of the method. Conclusion: The demyelination load in metachromatic leukodystrophy can be determined in a time-efficient manner using a semiautomatic algorithm, showing high agreement with the current gold standard.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据