Article
Medicine, General & Internal
Haejung Kim, Eun Young Ko, Ka Eun Kim, Myoung Kyoung Kim, Ji Soo Choi, Eun Sook Ko, Boo-Kyung Han
Summary: This study found that kinetic information provides added value for breast lesion evaluation on abbreviated breast MRI (AB-MRI). By analyzing 207 breast lesions, it was discovered that adding dynamic information such as the degree of enhancement can increase the specificity of AB-MRI without compromising its sensitivity.
Review
Oncology
Amy M. Fowler, Roberta M. Strigel
Summary: PET-MRI is a hybrid imaging technology that combines the advantages of PET and MRI, which plays an important role in the early diagnosis, staging, prognosis, tumor phenotyping, and assessment of treatment response in breast cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhen Ren, Federico D. Pineda, Frederick M. Howard, Elle Hill, Teodora Szasz, Rabia Safi, Milica Medved, Rita Nanda, Thomas E. Yankeelov, Hiroyuki Abe, Gregory S. Karczmar
Summary: The study found that breast cancer patients with similar kinetic parameters in ipsi- and contra-lateral normal parenchyma before NAT were more likely to achieve pathologic complete response. Patients classified as RCB II after NAT showed higher values in normal parenchyma and tumor kinetics.
ACADEMIC RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia C. Carmona-Bozo, Roido Manavaki, Ramona Woitek, Turid Torheim, Gabrielle C. Baxter, Corradina Caraco, Elena Provenzano, Martin J. Graves, Tim D. Fryer, Andrew J. Patterson, Fiona J. Gilbert
Summary: Through combined (18)F-FMISO-PET/MRI, we found a relationship between hypoxia and vascular function in breast cancer, highlighting the heterogeneity within tumour regions. Hypoxia was positively correlated with lesion size, but negatively correlated with DCE-MRI parameters.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Pierrick Gouel, Francoise Callonnec, Franchel-Rais Obongo-Anga, Pierre Bohn, Emilie Leveque, David Gensanne, Sebastien Hapdey, Romain Modzelewski, Pierre Vera, Sebastien Thureau
Summary: This study demonstrates the value of combining PET and MRI to define hypoxic subvolumes and determine the radiotherapy dose in head and neck cancers. Hypoxic subvolumes are associated with poor prognosis and response to treatment. Quantitative MRI parameters show differences between hypoxic and normoxic volumes, suggesting the ability to identify hypoxic subvolumes for additional radiotherapy doses.
Article
Radiology, Nuclear Medicine & Medical Imaging
Soo-Yeon Kim, Nariya Cho, Hyunsook Hong, Youkyoung Lee, Heera Yoen, Yeon Soo Kim, Ah Reum Park, Su Min Ha, Su Hyun Lee, Jung Min Chang, Woo Kyung Moon
Summary: This study compared the efficacy of abbreviated breast MRI with full-protocol MRI in women with a personal history of breast cancer. The results showed that abbreviated MRI had comparable sensitivity and higher specificity, making it suitable for breast cancer detection in these women.
Article
Oncology
Xiaoxin Hu, Luan Jiang, Chao You, Yajia Gu
Summary: The study results indicate that increased BPEV is highly correlated with a high risk of breast cancer, while FGT is not significantly associated.
FRONTIERS IN ONCOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Elias George Kikano, Stefanie Avril, Holly Marshall, Robert Stanley Jones, Alberto J. Montero, Norbert Avril
Summary: Evaluation of F-18 Fluorodeoxyglucose (FDG) with Positron Emission Tomography (PET) in breast cancer patients requires consideration of normal variants and potential pitfalls, such as increased glucose metabolism in benign breast diseases and malignancies other than breast cancer. Inflammatory changes can also impact the accuracy of PET/CT in breast cancer staging, highlighting the importance of careful evaluation and comparison with anatomical imaging.
SEMINARS IN NUCLEAR MEDICINE
(2021)
Article
Medicine, General & Internal
Andra Piciu, Doina Piciu, Narcis Polocoser, Anita A. Kovendi, Iulia Almasan, Alexandru Mester, Dragos-Stefan Morariu, Calin Cainap, Simona Sorana Cainap
Summary: The study analyzed the F18-FDG PET/CT systemic staging in male patients with breast cancer, revealing a high rate of distant metastases or synchronous cancers.
Review
Oncology
Rosa Di Micco, Letizia Santurro, Maria Luisa Gasparri, Veronica Zuber, Giovanni Cisternino, Sara Baleri, Manuela Morgante, Nicole Rotmensz, Carla Canevari, Francesca Gallivanone, Paola Scifo, Annarita Savi, Patrizia Magnani, Ilaria Neri, Nadia Ferjani, Elena Venturini, Claudio Losio, Isabella Sassi, Giampaolo Bianchini, Pietro Panizza, Luigi Gianolli, Oreste Davide Gentilini
Summary: PET/MRI is a relatively new imaging tool under investigation for its role in breast cancer patients. Studies have shown promising diagnostic performance of PET/MRI in breast cancer, especially in axillary staging, which may lead to further de-escalation of surgical treatments in the future.
Article
Chemistry, Physical
Prashant Pandey, Aparajita Shankar, Michael Biney, Vipin K. Saini
Summary: In this study, ordered-mesoporous silica SBA-15 was modified into a composite adsorbent PANI-SBA-15, with a higher adsorption rate and capacity for amoxicillin due to increased surface negative charge. The adsorption mechanism is regulated by pore-diffusion and regeneration with HNO3 results in high efficiency. PANI-SBA-15 successfully removes impurities from simulated hospital wastewater samples.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Solene Collet, Jean-Sebastien Guillamo, David Hassanein Berro, Ararat Chakhoyan, Jean-Marc Constans, Emmanuele Lechapt-Zalcman, Jean-Michel Derlon, Mathieu Hatt, Dimitris Visvikis, Stephane Guillouet, Cecile Perrio, Myriam Bernaudin, Samuel Valable
Summary: Conventional MRI plays a crucial role in managing high-grade glioma patients, but multiparametric MRI and PET tracers provide additional information to characterize tumor metabolism and heterogeneity. This study focused on evaluating proliferation, hypervascularization, and hypoxia in glioblastoma patients, finding marked differences in tracer uptake and rCBV maps between individuals, with certain tumor regions extending beyond the contrast enhancement volume.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Lei Xia, Xiangxi Meng, Li Wen, Nina Zhou, Teli Liu, Xiaoxia Xu, Feng Wang, Zhen Cheng, Zhi Yang, Hua Zhu
Summary: A novel biocompatible melanin nanoprobe coupled with a specific inhibitor is developed for targeted multimodal diagnosis and treatment of prostate cancer, demonstrating functionalities for photoacoustic imaging and photothermal therapy. The nanoparticles also have the capability for radioisotope therapy and photothermal therapy, showing a significant inhibitory effect on prostate cancer growth.
Article
Radiology, Nuclear Medicine & Medical Imaging
H. Sallam, L. Lenga, C. Solbach, S. Becker, T. J. Vogl
Summary: This study evaluated the prognostic value of background parenchymal enhancement (BPE) in breast magnetic resonance imaging (MRI) for high-risk breast cancer patients. The results showed weak or no significant correlations between BPE and patient age, fibroglandular tissue (FGT), Breast Imaging Reporting and Data System (BIRADS) categories, presence of breast cancer, and expression of human epidermal growth factor receptor 2 (HER2), progesterone receptor (PR), estrogen receptor (ER), and Ki67. Therefore, BPE in MRI may not be a reliable biomarker for breast cancer development.
CLINICAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Noam Nissan, Vera Sorin, Ethan Bauer, Debbie Anaby, David Samoocha, Yael Yagil, Renata Faermann, Osnat Halshtok-Neiman, Anat Shalmon, Michael Gotlieb, Miri Sklair-Levy
Summary: This study investigates the application of computer-added diagnosis (CAD) in dynamic contrast-enhanced (DCE) MRI of healthy lactating breasts. The results show that false-positive CAD coloring is common among lactating patients, with background parenchymal enhancement (BPE) being the main cause. Lactation BPE is characterized by non-mass enhancement (NME) shape, bilateral and symmetric coloring. Compared to healthy non-lactating controls, lactating patients have a significantly increased probability of CAD false positives, while CAD features are mostly inconclusive when compared to breast cancer patients, although increased size parameters are significantly associated with lactation BPE.
ACADEMIC RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anthony J. Young, Austin R. Pantel, Varsha Viswanath, Tiffany L. Dominguez, Mehran Makvandi, Hsiaoju Lee, Shihong Li, Erin K. Schubert, Daniel A. Pryma, Michael D. Farwell, Robert H. Mach, Fiona Simpkins, Lilie L. Lin, David A. Mankoff, Robert K. Doot
Summary: The PARP family of proteins is involved in various functions, including the DNA damage response. PARP inhibitors have shown therapeutic efficacy in cancer treatment, and F-18-fluorthanatrace uptake can serve as a biomarker for response to PARP inhibitor therapy. SUVmax and SUVpeak are robust measures of PARP-1 binding.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Austin R. Pantel, Varsha Viswanath, Mark Muzi, Robert K. Doot, David A. Mankoff
Summary: Kinetic analysis in dynamic PET imaging allows estimation of biologic processes related to disease, going beyond static uptake measures. This two-part continuing education paper reviews principles and methodology of kinetic modeling in part I and showcases benefits of kinetic modeling in oncologic imaging through case examples in part II.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Austin R. Pantel, Varsha Viswanath, Mark Muzi, Robert K. Doot, David A. Mankoff
Summary: PET enables noninvasive imaging of regional in vivo cancer biology. By engineering a radiotracer to target specific biologic processes of relevance to cancer (e.g., cancer metabolism, blood flow, proliferation, and tumor receptor expression or ligand binding), PET can detect cancer spread, characterize the cancer phenotype, and assess its response to treatment. However, static imaging at a single time point may not utilize all the information that PET cancer imaging can provide, and reliance on static imaging measures alone may lead to misleading results. This review introduces the principles and examples of kinetic analysis for oncologic PET imaging, highlighting the added benefits over static imaging.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hwan Lee, Joshua S. Scheuermann, Anthony J. Young, Robert K. Doot, Margaret E. Daube-Witherspoon, Erin K. Schubert, Matthew A. Fillare, David Alexoff, Joel S. Karp, Hank F. Kung, Daniel A. Pryma
Summary: In this pilot study, Ga-68-P16-093 showed superior diagnostic performance compared to conventional imaging methods for prostate cancer, leading to changes in patient management. Further investigation in larger clinical studies is warranted to explore its potential.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Chaya S. Moskowitz, Mattea L. Welch, Michael A. Jacobs, Brenda F. Kurland, Amber L. Simpson
Summary: This article reviews common issues in radiomic research, with a focus on study design and statistical analysis considerations, and proposes approaches to avoid these pitfalls.
Review
Oncology
Jean M. Seely, Peter R. Eby, Martin J. Yaffe
Summary: The negative findings of the Canadian National Breast Screening Study (CNBSS) trials, conducted 40 years ago, continue to heavily impact screening policies worldwide. This review highlights the flaws of the CNBSS trials, including inadequate power, poor quality mammography, inclusion of symptomatic women, and a study design allowing for randomization violation. These trials failed to demonstrate the mortality benefit of screening mammography, making them outliers among eight screening mammography RCTs.
JOURNAL OF BREAST IMAGING
(2022)
Article
Oncology
Jean M. Seely, Peter R. Eby, Paula B. Gordon, Shushiela Appavoo, Martin J. Yaffe
Summary: This study investigates the reasons why the Canadian National Breast Screening Study (CNBSS) did not demonstrate a reduction in mortality with mammography. It reveals concerns related to the validity of the randomization process, methods of recruiting women for the trials, and the training of CNBSS staff. Interviews with former CNBSS personnel confirm the presence of systematic recruitment of women with preexisting breast cancer symptoms, inadequate training and experience of the screening personnel, substandard imaging equipment, poor quality of mammography images, and reluctance of surgeons to perform biopsies or surgeries for women with suspicious abnormalities found only on screening mammography. These accounts highlight the inadequacy of CNBSS in assessing the efficacy of screening mammography and emphasize the need to consider the evidence from other randomized trials.
JOURNAL OF BREAST IMAGING
(2022)
Article
Oncology
Peter R. Eby, Sujata Ghate, Regina Hooley
Summary: Research confirms that regular screening with mammography significantly reduces breast cancer mortality, but the efficacy of screening remains a subject of debate. Recent studies utilize observational data and study designs to address these debates and inform the construction of effective databases for continuous assessment of optimal screening techniques in the current era of rapid medical technology advancement.
JOURNAL OF BREAST IMAGING
(2022)
Article
Cell Biology
Robert K. Doot, Anthony J. Young, Ilya M. Nasrallah, Reagan R. Wetherill, Andrew Siderowf, Robert H. Mach, Jacob G. Dubroff
Summary: Neuroinflammation is an important factor in neurodegenerative diseases and is mediated by microglia. This study used [F-18]NOS PET imaging to measure neuroinflammation in idiopathic Parkinson's disease patients and found increased oxidative stress as a marker of inflammation in early-stage disease.
Editorial Material
Public, Environmental & Occupational Health
Daniel B. Kopans, Richard E. Sharpe Jr, Peter R. Eby
Summary: Debates on breast cancer screening have continued due to the lack of data on the method of detection and its impact on the decline in breast cancer deaths.
JOURNAL OF MEDICAL SCREENING
(2023)
Meeting Abstract
Neurosciences
Corinde Wiers, Anthony Young, Juliana Byanyima, Xinyi Li, Robert Doot, Sianneh Vesslee, Rishika Reddy, Zhenhao Shi, Reagan Wetherill, Timothy Pond, Nora Volkow, Henry Kranzler, Jacob Dubroff
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Ali Nabavizadeh, Stephen Bagley, Robert Doot, Jeffrey B. Ware, Anthony Young, Satyam Ghodasara, Chao Zhao, Hannah Anderson, Erin Schubert, Fraser Henderson, Austin Pantel, H. Isaac Chen, John Y. K. Lee, Nduka M. Amankulor, Donald M. O'Rourke, Arati Desai, MacLean Nasrallah, Steven Brem
JOURNAL OF NUCLEAR MEDICINE
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Austin Pantel, Mehran Makvandi, Hyoung Kim, Joanna Weeks, Drew Torigian, Nawar Latif, Lainie Martin, Janos Tanyi, Mark Morgan, Robert Doot, Lilie Lin, David Mankoff, Robert Mach, Fiona Simpkins
JOURNAL OF NUCLEAR MEDICINE
(2022)
Meeting Abstract
Oncology
Ali Nabavizadeh, Stephen Bagley, Jeffrey B. Ware, Robert K. Doot, Anthony Young, Satyam Ghodasara, Chao Zhao, Hannah Anderson, Erin Schubert, Erica L. Carpenter, Jacob Till, Fraser Henderson, Austin R. Pantel, Isaac Chen, John Yk Lee, Nduka Amankulor, Donald O'Rourke, Arati Desai, MacLean Nasrallah, Steven Brem
Article
Oncology
Hsiaoju S. Lee, Sally W. Schwarz, Erin K. Schubert, Delphine L. Chen, Robert K. Doot, Mehran Makvandi, Lilie L. Lin, Elizabeth S. McDonald, David A. Mankoff, Robert H. Mach
Summary: This article describes the development of F-18-FTT as a radiotracer for imaging PARP-1 expression levels in breast and ovarian cancer patients. It also discusses the preparation and submission of an exploratory investigational new drug application to the FDA and the need for a commercialization strategy to overcome financial barriers in multicenter clinical trials.
RADIOLOGY-IMAGING CANCER
(2022)