Article
Pharmacology & Pharmacy
Dalila Miele, Xin Xia, Laura Catenacci, Milena Sorrenti, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, John J. Rossi, Maria Cristina Bonferoni
Summary: Oligonucleotide therapeutics such as miRNAs and siRNAs are developed to modulate gene expression, but face issues of instability and easy degradation. Viral and non-viral vectors are used for efficient delivery, with non-viral vectors like polymeric nanocarriers providing safer and more effective means of delivery.
Article
Biochemistry & Molecular Biology
M. Torres-Ramos, M. F. Martin-Marquez, Maria del Carmen Leal-Moya, Suresh Ghotekar, Jorge Alberto Sanchez-Burgos, Alejandro Perez-Larios
Summary: This paper reports the green synthesis of PLGA-TiO2 nanocomposite using a natural extract and its characterization. The study used UV-visible spectrometry, scanning electron microscopy, infrared spectroscopy, and X-ray diffraction to analyze the properties of the nanoparticles. The results showed that terpenes enhance the synthesis and stabilization of titanium dioxide nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Feipeng Yang, Maleen Cabe, Hope A. Nowak, Kelly A. Langert
Summary: In this study, different size groups of poly(lactic-co-glycolic) acid (PLGA) nanoparticles and chitosan-PLGA nanoparticle counterparts were prepared by adjusting key formulation parameters. The effects of size and surface modification on drug loading and release were investigated, and changes in mucoadhesion were quantified.
Article
Biochemistry & Molecular Biology
Saeem Ahmad, Iram Khan, Jayamanti Pandit, Nasr A. Emad, Shahnaj Bano, Khalid Imtiyaz Dar, M. Moshahid Alam Rizvi, Mohd Danish Ansari, Mohd. Aqil, Yasmin Sultana
Summary: This study successfully developed chitosan-coated PLGA nanoparticles for nose-to-brain delivery of carmustine. The optimized nanoparticles showed satisfactory levels in terms of particle size, entrapment efficiency, drug release, and permeability. The results suggested that chitosan-coated nanoparticles could be a promising approach for delivering carmustine to treat Glioblastoma multiforme via intranasal administration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Biomaterials
Mark Rutschmann, Natalja Redinger, Ulrich E. Schaible, Claus Feldmann
Summary: AMC@SiO2 core@shell nanocarriers with a high drug load of 0.8 mg mg(-1) are prepared using a solvent-antisolvent approach. The nanocarriers have a mean diameter of 240 nm, with an inner AMC core of 200 nm and an outer silica shell of 20 nm. The size, structure, and composition of the nanocarriers are confirmed by various characterization methods. The AMC@SiO2 core@shell nanocarriers show promising potential for the treatment of multidrug resistant bacterial pathogens.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Pharmacology & Pharmacy
Abdullah Alshememry, Mohd Abul Kalam, Abdulhadi Almoghrabi, Abdulwahab Alzahrani, Mudassar Shahid, Azmat Ali Khan, Anzarul Haque, Raisuddin Ali, Musaed Alkholief, Ziyad Binkhathlan, Aws Alshamsan
Summary: The present study investigates the simultaneous encapsulation and delivery of DOX and NAR using PLGA-NPs and CS-coated PLGA-NPs to enhance their efficacy and synergistic anticancer activity, while reducing toxicity. The results demonstrate that F4 exhibits the best drug release and cytotoxicity, indicating its potential as an effective nano-carrier for DOX and NAR.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Madhuri Dandamudi, Peter McLoughlin, Gautam Behl, Sweta Rani, Lee Coffey, Anuj Chauhan, David Kent, Laurence Fitzhenry
Summary: The study developed a nanoparticulate system for topically applied corticosteroids, aiming to reduce the treatment burden for patients and doctors. Surface-modified nanoparticles showed controlled drug release and improved bioavailability, making them potential candidates for treating acquired retinal vasculopathies.
Review
Chemistry, Multidisciplinary
Eman Jaradat, Edward Weaver, Adam Meziane, Dimitrios A. Lamprou
Summary: In conventional drug administration, drug molecules may not effectively reach the pathological site, so nanoparticles (NPs) as drug carriers have potential. NPs have a large surface area and quantum properties. Traditional methods for manufacturing NPs have limitations and new methods need to be investigated.
Article
Chemistry, Multidisciplinary
Ayaka Harada, Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Tomohiro Sawa, Takuro Niidome
Summary: Advances in drug delivery systems have allowed specific delivery of drugs to target cells. This study demonstrates the selective delivery of SubAB to macrophages and its anti-inflammatory effects by modifying it with PLGA nanoparticles. These findings provide a useful technique for protein delivery to macrophages and support the application of drug delivery systems in the treatment of inflammatory diseases.
Article
Chemistry, Multidisciplinary
Barbora Boltnarova, Jana Kubackova, Josef Skoda, Alzbeta Stefela, Monika Smekalova, Petra Svacinova, Ivona Pavkova, Milan Dittrich, Daniel Scherman, Jarmila Zbytovska, Petr Pavek, Ondrej Holas
Summary: In this study, various PLGA polymer nanospheres were prepared for macrophage-targeted drug delivery using nanoprecipitation and emulsification solvent evaporation methods. The larger nanospheres, prepared using nanoprecipitation, showed enhanced distribution into macrophages. The experimental PLGA nanoformulations surpassed the commercially available polymer in their capacity as macrophage-specific carriers, with no observed effects on cell viability or proinflammatory response.
Review
Polymer Science
Iyyakkannu Sivanesan, Judy Gopal, Manikandan Muthu, Juhyun Shin, Selvaraj Mari, Jaewook Oh
Summary: This review discusses the preparation, drug delivery applications, and current status of green synthesis of chitosan. It highlights the lack of systematic research in the green synthesis of chitosan and calls for more innovative green processes to be explored. Additionally, there is a lack of reports on the application of green synthesized chitosan nanoforms and nanocomposites towards drug delivery applications, which is an area that deserves more research focus.
Article
Biochemistry & Molecular Biology
Preeti Yadav, Awadh Bihari Yadav, Preksha Gaur, Vartika Mishra, Zul- Huma, Neelesh Sharma, Young-Ok Son
Summary: Mastitis is a devastating economic disease in dairy cattle, commonly occurring during the dry period or early lactation. Escherichia coli and Staphylococcus aureus are the main causative agents of mastitis in India. The use of ciprofloxacin-encapsulated nanocarriers shows potential in improving drug availability and providing an effective treatment for mastitis.
Review
Biochemistry & Molecular Biology
Ghazaleh Salmanian, S. A. Hassanzadeh-Tabrizi, Narjes Koupaei
Summary: Magnetic chitosan nanocomposites with multifunctional tasks such as localized tumor heating under magnetic field and controlled drug release are highly demanded. Combining different types of magnetic cores and engineered chitosan shells can create unique characteristics with biocompatibility, the least toxic effects, controlled drug release, and the ability to carry various medicines for long-term circulation in the body. Recent advances in the synthesis and applications of magnetic chitosan nanocomposites for hyperthermia and drug delivery are summarized in this review.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Jun Wu, Xinyu Wang, Haiwen Li, Mingyue Qu, Wenbin Sun, Xu Yan, Zheng Zhao, Binbin Li
Summary: In this study, chitosan-coated PLGA microspheres with rough surface and hollow structure were successfully prepared using a modified method. These microspheres can be used as drug carriers to improve drug loading efficiency and anticancer effect, and reduce drug administration frequency. The chitosan-modified microspheres showed prolonged anticancer activity and promoted apoptosis, suggesting their potential application in liver cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Anna Czapka, Christian Grune, Patrick Schaedel, Vivien Bachmann, Karl Scheuer, Michael Dirauf, Christine Weber, Alexios-Leandros Skaltsounis, Klaus D. Jandt, Ulrich S. Schubert, Dagmar Fischer, Oliver Werz
Summary: In this study, we encapsulated 6BIGOE into sustainable solvents-based PLGA nanoparticles, which resulted in efficient drug delivery systems with improved cellular uptake and the ability to mask cytotoxic effects. The anti-inflammatory properties of 6BIGOE were fully retained in these nanoparticles.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Baoqi Dong, Tingping Hou, Kaiming Wu, Bernie Rolfe, Lingxue Kong, Minghui Cai, Peter Hodgson
Summary: The effect of a 12 Tesla magnetic field on the microstructure and carbon partitioning in a low temperature bainitic steel was studied. The high magnetic field accelerated the formation of bainitic ferrite, resulting in refined laths and uniform distribution. It also promoted carbon partitioning to retained austenite and increased the carbon accommodation of the retained austenite.
MATERIALS CHARACTERIZATION
(2023)
Article
Chemistry, Multidisciplinary
Xiangyang Guo, Chung Kim Nguyen, Aishani Mazumder, Yichao Wang, Nitu Syed, Enrico Della Gaspera, Torben Daeneke, Sumeet Walia, Samuel J. Ippolito, Ylias Sabri, Yongxiang Li, Ali Zavabeti
Summary: Various non-stratified two-dimensional (2D) materials can be obtained from liquid metal surfaces that are not naturally accessible. These materials have high-quality oxide layers that can be transferred onto desired substrates. The liquid metal-derived 2D oxides have versatile applications, but their gas-sensing properties remain underexplored.
Article
Engineering, Chemical
Shuaifei Zhao, Paul H. M. Feron, Xiao Chen, Inci Boztepe, Jianhua Zhang, Nouman Rafique Mirza, Lingxue Kong
Summary: In this study, a simple and highly effective method to enhance the water vapor flux in vacuum membrane distillation (VMD) was proposed and demonstrated by introducing a gas flow on the vacuum side. Experimental and modelling results confirmed that gas flow can effectively enhance mass transfer in VMD by minimizing the boundary layer effect. A higher gas flow velocity results in a much higher water vapor flux due to reduced boundary layer effect and temperature polarization. The study provides a cost-effective method to enhance the water vapor flux in VMD and contributes to understanding vapor condensation and mass transfer mechanisms in thermally-driven membrane processes.
Review
Biochemistry & Molecular Biology
Senlin Gu, Liangliang Zhang, Liliana de Campo, Luke A. O'Dell, Dong Wang, Guang Wang, Lingxue Kong
Summary: Mesoporous materials based on lyotropic liquid crystal templates offer a solution to water scarcity, while polyamide-based thin-film composite membranes have trade-offs between permeability and selectivity. This review explores the advancements in fabricating active layers using liquid crystal templates, analyzes membrane performance, and compares the effects of different substrates on TFC membranes. It also discusses strategies for surface modification and interlayer introduction, and techniques for detecting interfacial structures.
Review
Agriculture, Multidisciplinary
Ananya Padmakumar, Chowdary Pavani, Kalyani Eswar, Lingxue Kong, Wenrong Yang, Subramanium Gopalakrishnan, David Miles Cahill, Aravind Kumar Rengan
Summary: The use of bacterial biocontrol agents (BBCAs) in plant protection has increased due to the rising awareness of chemical risks and the need for sustainable agriculture. Nanotechnology has facilitated the development of efficient and ecologically sound nanoformulations, such as bacteria premised nanobiopesticides (B-NBPs). These B-NBPs are synthesized using nanomaterials with amended properties at the nanoscale. This article provides an overview of BBCAs and their antagonistic mechanisms, focusing on the significance of BNPs in plant infection management and addressing concerns related to the efficacy of B-NBPs.
ACS AGRICULTURAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Xiaodi Wu, Zheng Li, Jin Hu, Shumin Wang, Yichao Wang, Peng Lin, Hong Zhou, Wei-Wei Zhao
Summary: Scientists have been seeking a solution for developing an organic photoelectrochemical transistor (OPECT) biosensor with a removed background, but this challenge remains. However, by tailoring a unique heterogeneous light antenna as the functional gating module and its cascade interaction with a proper channel, we have successfully addressed this issue. This achievement resulted in an OPECT with minimal background and the highest current gain of 19,000.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Milad Laghaei, Mohsen Ghasemian, Mahmoud Reza Ghandehari Ferdowsi, Juerg A. Schuetz, Lingxue Kong
Summary: This study investigates the fabrication of nanoporous composites of titanium-vanadium oxide using magnetron sputtering, electrochemical anodization, and annealing processes. The effect of varying vanadium sputtering power on the composite semiconductors and their photodegradation performance was studied. The results showed that the composite with the lowest vanadium content exhibited the highest degradation efficiency under solar-simulated irradiation due to its homogeneous vanadium dispersion and lower recombination possibility.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Chemical
Riyadh Al-Attabi, Fenghua She, Shuaifei Zhao, Ludovic F. Dumee, Jurg A. Schutz, Weihong Xing, Zhaoxiang Zhong, Lingxue Kong
Summary: Electrospinning was used to synthesize nanofiber membranes from polyvinylidene fluoride (PVDF) for separating airborne contaminants. By optimizing the electrospinning process, scalable and comfortable PVDF nanofiber membranes with high filtration efficiency were achieved. Compared to commercial surgical face masks, the PVDF nanofiber membranes had smaller fiber diameter, higher mechanical strength, and better filtration efficiency.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Albert Guirguis, Wenrong Yang, Xavier A. Conlan, Lingxue Kong, David M. Cahill, Yichao Wang
Summary: Artificially augmented photosynthesis in nano-bionic plants requires tunable nano-antenna structures with specific properties, such as physiochemical and optoelectronic properties, as well as unique light conversion capabilities. The use of carbon dots as nanomaterials has shown promising results in enhancing photosynthesis through tunable uptake, translocation, and biocompatibility. This review discusses the recent progress in fabricating nano-antennas based on carbon dots and their performance in artificially boosted photosynthesis.
Article
Engineering, Environmental
Ahmed O. Rashed, Chi Huynh, Andrea Merenda, Julio Rodriguez-Andres, Lingxue Kong, Takeshi Kondo, Joselito M. Razal, Ludovic F. Dumee
Summary: By engineering dry-spun ultrafiltration carbon nanotube (CNT) membranes coated with anti-viral SnO2 thin films, an efficient approach for simultaneous filtration and disinfection of waterborne Human Coronavirus 229E (HCoV-229E) is proposed.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Review
Chemistry, Physical
Milad Laghaei, Mohsen Ghasemian, Weiwei Lei, Lingxue Kong, Qi Chao
Summary: The conversion of carbon dioxide into valuable chemicals by photoreduction using two-dimensional nanomaterials, such as boron nitride, shows promising potential. However, modification strategies are needed to enhance their efficiency in CO2 reduction due to their large band gaps and inert surface chemistry. Various modification techniques, including doping, fabricating composite heterojunctions, and engineering defects, have been developed to tailor CO2 adsorption/conversion. Challenges regarding large-scale production, stability, and product selectivity are discussed, along with suggestions for future studies.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Review
Engineering, Environmental
Akbar Samadi, Zhuan Wang, Shaobin Wang, S. K. Nataraj, Lingxue Kong, Shuaifei Zhao
Summary: This review critically assesses PANI-based adsorbents in terms of their advantages, disadvantages, and separation mechanisms in pollutant removal. It highlights the significant roles of low-cost materials as well as emerging 2D nanosheets in enhancing the performance of PANI-based adsorbents.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Yayun Zheng, Yuefo Yi, Ziyi Yang, Wenbin Zhou, Yichao Wang, Zhengfei Chen
Summary: A crystalline Ti2O1.3(PO4)(1.6)/TiO2 carbon-coated composite was successfully synthesized using a glucose-modified hydrothermal method. Compared to the counterpart prepared without glucose modification, this composite exhibits the highest reversible capacities, excellent rate properties, and remarkable cycling performances, with a capacity of 233.9 mA h g(-1) maintained after 200 cycles at 1000 mA g(-1).
CHEMICAL COMMUNICATIONS
(2023)
Article
Agricultural Engineering
Lin Li, Dou Du, Chengen He, Lianqing Yu, Wenyang Tang, Shuang Hu, Xinyu Wang, Zhuan Fu, Liangjun Xia, Weilin Xu, Lingxue Kong
Summary: A reduced graphene oxide/cotton yarn supercapacitor was fabricated using a green hydrothermal approach without the use of any chemical reducing agents. The study investigated the reduction efficiency of graphene oxide nanoparticles and morphology change of cotton fibers under different hydrothermal treatments, and their effects on the energy storage performance of the supercapacitor.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
