期刊
AAPS PHARMSCITECH
卷 12, 期 2, 页码 453-460出版社
SPRINGER
DOI: 10.1208/s12249-011-9587-0
关键词
apparent viscosity; calcium alginate gel; compression; gel properties; viscoelasticity
The purpose of this study is to determine whether sodium alginate solutions' rheological parameters are meaningful relative to sodium alginate's use in the formulation of calcium alginate gels. Calcium alginate gels were prepared from six different grades of sodium alginate (FMC Biopolymer), one of which was available in ten batches. Cylindrical gel samples were prepared from each of the gels and subjected to compression to fracture on an Instron Universal Testing Machine, equipped with a 1-kN load cell, at a cross-head speed of 120 mm/min. Among the grades with similar % G, (grades 1, 3, and 4), there is a significant correlation between deformation work (L (E)) and apparent viscosity (eta (app)). However, the results for the partial correlation analysis for all six grades of sodium alginate show that L (E) is significantly correlated with % G, but not with the rheological properties of the sodium alginate solutions. Studies of the ten batches of one grade of sodium alginate show that eta (app) of their solutions did not correlate with L (E) while tan delta was significantly, but minimally, correlated to L (E). These results suggest that other factors-polydispersity and the randomness of guluronic acid sequencing-are likely to influence the mechanical properties of the resultant gels. In summary, the rheological properties of solutions for different grades of sodium alginate are not indicative of the resultant gel properties. Inter-batch differences in the rheological behavior for one specific grade of sodium alginate were insufficient to predict the corresponding calcium alginate gel's mechanical properties.
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