Article
Chemistry, Applied
Xinya Wang, H. Douglas Goff, Steve W. Cui
Summary: Yellow mustard gum (YMG) is a natural stabilizer that improves the texture, quality, and shelf life of food products. When mixed with kappa-carrageenan or locust bean gum (LBG), significant synergistic interactions were observed, resulting in stronger hydrogels compared to their individual gums. The gel characteristics and gelation behaviors of the mixtures were different, with YMG-kappa-carrageenan forming a firm and elastic gel and YMG-LBG forming an adhesive and paste-like gel.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Applied
Faezeh Khoobbakht, Sadaf Khorshidi, Fereshte Bahmanyar, Seyede Marzieh Hosseini, Nafise Aminikhah, Mehdi Farhoodi, Leila Mirmoghtadaie
Summary: This study investigated the structural, mechanical, and rheological properties of a compound hydrogel using agar/locust bean/xanthan gum (ALX). The results showed that the addition of locust bean gum (LBG) and xanthan gum (XG) to agar could significantly improve the springiness and reduce the hardness of agar hydrogel, making it a promising alternative to high-bloom gelatin.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Adam O'Connell, Francisco M. Goycoolea, Alessandro Gulotta, Peter Holmqvist, Peter Schuetz, Johan Mattsson
Summary: Locust bean gum (LBG) is widely used in various industries, and understanding its solution behaviour is crucial for formulation design. This study investigated the structure and dynamics of LBG in aqueous solution using different techniques. It was found that steady state shear rheology mainly probes the dispersed LBG fraction, while scattering response is dominated by supramolecular LBG aggregates. Three viscosity-concentration regimes were identified, with scaling behaviour consistent with predictions for neutral flexible polymers. Our study provides comprehensive insight into the structure and dynamics of aqueous LBG solutions, paving the way for a better understanding and control of LBG-based formulations.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Multidisciplinary
Binbin Liu, Yuan Huang, Jiawei Wang, Zixuan Li, Guoshen Yang, Shunyu Jin, Emad Iranmanesh, Pritesh Hiralal, Hang Zhou
Summary: The quasi-solid-state ZnSO4/MnSO4 electrolyte prepared using locust bean gum demonstrated high ionic conductivity, stability, and excellent discharge performance in Zn-MnO2 batteries. It showed potential for future development of solid-state energy storage devices with bio-compatibility and environmental friendliness.
Article
Polymer Science
Hui Zhang, Zhun Yan, Fan Xie, Yanjun Tian, Lianzhong Ai
Summary: The synergistic interaction and gelling kinetics between xanthan gum (XG) and locust bean gum (LBG) were evaluated at different mass ratios. The mixture of XG/LBG 3:7 showed the strongest gel structure and the densest entanglements. This study provides insights for designing novel food structures using XG-LBG blends.
Review
Biochemistry & Molecular Biology
Max Petitjean, Jose Ramon Isasi
Summary: Locust bean gum (LBG) is a vegetable galactomannan extracted from carob tree seeds and commonly used as a thickening agent in the food industry. It has unique properties due to its synergistic behavior with other biopolymers and can be easily modified or crosslinked. LBG and its derivatives find applications in various fields such as food, encapsulation, drug delivery, packaging, batteries, and catalyst supports. The use of LBG contributes to the development of greener products as it is biodegradable and non-toxic.
Article
Biochemistry & Molecular Biology
Max Petitjean, Jose Ramon Isasi
Summary: In this study, three different polysaccharides were crosslinked with or without beta-cyclodextrin using citric acid in different ratios to create 'green' hydrogel matrices with favorable swelling behavior for sorption. The amount of beta-cyclodextrin groups is not the only factor affecting sorption capability, as the polysaccharides themselves also play a role based on their characteristic functional groups, chain conformation, and degrees of swelling. The Hill equation provided the best fit for analyzing sorption capabilities of a model sorbate, offering insights into the interaction mechanisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Adam O'Connell, Yadira Gonzalez-Espinosa, Francisco M. Goycoolea, Peter Schuetz, Johan Mattsson
Summary: In this study, we characterised locust bean gum (LBG) using asymmetric flow field-flow fractionation (AF4) and light scattering techniques. Our results showed the presence of both aggregated and well-dispersed fractions in LBG, and we were able to provide structural information for both fractions. Our findings demonstrate the suitability of AF4 for LBG characterisation, with potential application to other similar galactomannans and associating polymer systems.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Keding Li, Yuqing Lei, Jun Liao, Yong Zhang
Summary: The graphene oxide/locust bean gum aerogels synthesized in ice crystal template showed excellent adsorption properties for Rhodamine-B and Indigo Carmine, with promising potential in removing water-soluble RhB from wastewater.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Biomedical
Yangyang Qu, Si He, Shixing Luo, Jinmin Zhao, Ruiming Liang, Chuanan Liao, Li Zheng
Summary: This study reports a novel photocrosslinkable, injectable locust bean gum-methacrylate hydrogel as a biomimetic extracellular matrix for cartilage repair. The hydrogel shows controllable degradation rate, improved mechanical properties, and excellent biocompatibility. In addition, it significantly induces chondrogenic differentiation of bone mesenchymal stem cells in vitro and accelerates cartilage healing in vivo after 8 weeks of therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Chemical
Ziming Wang, Bo Feng, Yuangan Chen
Summary: In this study, the suppressive effect of locust bean gum (LBG) on dolomite in scheelite flotation was investigated. It was found that LBG (18 mg/L) could effectively inhibit dolomite and achieve a grade of 65.69% in scheelite concentrate at pH = 9. The possible inhibition mechanism was proposed based on the results of XPS, FTIR, Zeta potential, and contact angle experiments, suggesting that LBG selectively accumulated on the dolomite surface and formed a stable complexation reaction with Mg2+.
MINERALS ENGINEERING
(2023)
Review
Pharmacology & Pharmacy
Madan Sai Poka, Marnus Milne, Anita Wessels, Marique Aucamp
Summary: This article discusses the feasibility of using sugars and polyols as carriers for SDs, as they possess several ideal characteristics. Recently, there has been increasing interest in the use of low-molecular-weight excipients. However, there are limited options available for safe, low molecular excipients, which opens the door again for sugars and polyols.
Article
Food Science & Technology
Xuejiao Xu, Shuhui Ye, Xiaobo Zuo, Sheng Fang
Summary: Improving the gel texture and stability of rice starch by natural hydrocolloids, such as guar gum and locust bean gum, has a significant impact on the development of gluten-free starch-based products. These gums modify the pasting properties and rheological behavior of rice starch, leading to improved viscoelastic properties and resistance to shear forces. Additionally, the thermodynamic properties of the gum-starch system retard the retrogradation of the starch gels, resulting in enhanced texture properties and freeze-thaw stability. These findings provide alternative approaches for formulating gluten-free recipes with improved texture and stability.
Article
Polymer Science
Ghassan H. Matar, Muberra Andac, Aykut Elmas
Summary: LBG/PVA hydrogels were synthesized without toxic crosslinking agents, showing pH and temperature-responsive behavior. The hydrogels exhibited a maximum swelling ratio at 37 degrees C and non-Fickian diffusion dominated the swelling process. The Elmas model had better fits at 277 K and 298 K, while the Peppas model performed better at 310 K, indicating their potential as biomaterials for drug delivery applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Food Science & Technology
Soulef Benkadri, Ana Salvador, Teresa Sanz, Mohammed Nasreddine Zidoune
Summary: This study used response surface methodology to optimize the addition of xanthan gum and locust bean gum to gluten-free rice flour supplemented by chickpea flour. The analysis revealed that linear terms significantly affected most parameters, with xanthan gum having a more pronounced effect, while interaction terms had a positive impact on specific volume but a negative impact on water activity of the biscuits. Overall, optimized conditions were developed to maximize specific volume and minimize water activity and hardness of the biscuits.
Article
Biochemical Research Methods
Harun Patel, Iqrar Ahmad, Harsha Jadhav, Rahul Pawara, Deepak Lokwani, Sanjay Surana
Summary: This study evaluated the impact of various acrylamide as an electrophilic warhead on the activity and selectivity of osimertinib, discovering a series of active and selective compounds that showed potential therapeutic effects against T790M EGFR mutants.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Polymer Science
Pankaj Dangre, Poorva P. Dusad, Alok D. Singh, Sanjay J. Surana, Kaushalendra K. Chaturvedi, Shailesh S. Chalikwar
Summary: In this study, a self-microemulsifying drug delivery system of hesperidin (SMEDDS-HES) was successfully incorporated into alginate beads to improve its bioavailability. The alginate beads exhibited excellent size and morphology characteristics, as well as promising drug release kinetics in simulated intestinal fluid. Experimental results showed good stability and hypoglycemic activity of the developed beads formulation.
Article
Chemistry, Medicinal
Matin Shaikh, Yashodeep Shinde, Rahul Pawara, Malleshappa Noolvi, Sanjay Surana, Iqrar Ahmad, Harun Patel
Summary: Osimertinib, a pyrimidine core-containing compound, is the only third-generation EGFR-TKI approved to target T790M resistance, but the C797S mutation may hamper its efficacy. Further research on overcoming resistance mechanisms is needed for effective treatment of NSCLC patients.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Rahul Pawara, Iqrar Ahmad, Deepika Nayak, Shivani Wagh, Avinash Wadkar, Azim Ansari, Sateesh Belamkar, Sanjay Surana, Chanakya Nath Kundu, Chandragauda Patil, Harun Patel
Summary: T790M mutation is the most common mechanism of acquired resistance to first-generation EGFR-TKIs. Two novel acrylamide linked quinazoline compounds, 2i and 11h, were synthesized and showed potent and selective anti-proliferative activity against gefitinib-resistant cell line NCI-H1975.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Prashant Chaudhari, Sanjaykumar Bari, Sanjay Surana, Atul Shirkhedkar, Sharad Wakode, Sandeep Shelar, Srikanth Racharla, Vinod Ugale, Mangesh Ghodke
Summary: This review discusses the potential of indolin-2-one in cancer treatment, recent progress in synthetic development, logical strategies in small molecule drug discovery, and the structure-activity relationship of indolin-2-one chemotype.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Pharmacology & Pharmacy
Avinash Ramrao Tekade, Pradeep Sadanand Mittha, Charushila Sopan Pisal
Summary: Neurological disorders such as Alzheimer's disease and Parkinson's disease are increasingly affecting the elderly population. The conventional route of administration faces the challenge of the blood brain and blood-cerebrospinal fluid barriers. Intranasal delivery is considered a promising alternative. Nanostructured lipid carriers, particularly second generation carriers, offer advantages in terms of stability, scalability, and drug targeting. This review explores the synergistic actions of oils/liquid lipids with synthetic drugs for therapeutic benefits.
ADVANCED PHARMACEUTICAL BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Pankaj Dangre, Navya J. Gurram, Sanjay J. Surana, Shailesh S. Chalikwar
Summary: We designed a solid self-microemulsifying drug delivery system (SMEDDS) of vitamin D-3 to improve its solubility and dissolution. By solidifying the liquid SMEDDS-Vit.D-3 formulation using Neusilin US2 and Aerosil 200 carriers, we achieved the transformation of crystalline to amorphous form of Vit.D-3 which resulted in enhanced aqueous solubility and dissolution behavior. The solid SMEDDS-Vit.D-3 showed good flow behavior and was developed into tablets that met pharmacopeial standards. In vitro dissolution studies demonstrated higher dissolution of Vit.D-3 in SMEDDS (liquid, solid, and tablet) compared to the unprocessed drug. The shelf life of the tablets was reported to be 28.12 months, indicating excellent stability of Vit.D-3 in solid SMEDDS.
Article
Plant Sciences
Dhanraj R. Mahajan, Anilkumar U. Tatiya, Manoj Girase, Chandragauda R. Patil, Prasad G. Jamkhande, Sanjay J. Surana, Mohan G. Kalaskar
Summary: This study aimed to investigate and validate the ethnobotanical knowledge on anti-inflammatory medicinal plants in the South-western Satpuda ranges. The results identified 32 plants with anti-inflammatory properties, including Grewia flavescens and Eulophia herbacea. These plants exhibited significant antiarthritic and anti-inflammatory activities, potentially attributed to the presence of gallic acid, quercetin, beta-sitosterol, and lupeol. Further research is needed to elucidate the exact mechanism of action of these plants.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Physical
Rahul Pawara, Iqrar Ahmad, Deepika Nayak, Sateesh Belamkar, Sanjay Surana, Chanakya Nath Kundu, Chandragauda Patil, Harun Patel
Summary: A series of novel double mutant EGFR-L858R/T790M TK inhibitors were discovered using structure-based drug design and traditional optimization strategies. These inhibitors showed improved selectivity and lower toxicity, making them promising candidates for targeting the double mutant EGFR-L858R/T790M TK.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Medicinal
Avinash R. Tekade, Mayuri R. Suryavanshi, Ashutosh B. Shewale, Vilas S. Patil
Summary: In this study, nanostructured lipid carriers (NLCs) of donepezil hydrochloride (DNZ HCl) were developed for the effective management of Alzheimer's disease (AD). Intranasal administration of DNZ NLCs containing Nigella sativa oil as a liquid lipid showed improved penetration and direct delivery to the brain, bypassing the blood brain barrier. The formulated DNZ HCl loaded NLCs demonstrated enhanced nasal penetration and improved drug distribution in the brain, making it a potentially effective intranasal drug delivery system for the management of Alzheimer's disease.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Pharmacology & Pharmacy
Avinash Tekade, Pratiksha Ghodke, Ashvini Patange, Pravin Patil
Summary: The purpose of this research was to develop a cubosomal in situ nasal gel using a novel mucoadhesive agent and to enhance the availability of sumatriptan succinate in brain with better CNS targeting potential for the efficient treatment of migraine. The cubosomal in situ nasal gel was prepared using glycerol monooleate (GMO) and Poloxamer 407 (P407). It showed a significantly higher concentration of sumatriptan succinate in the brain compared to intravenous solution, indicating its potential as a promising carrier for CNS-acting drugs through the intranasal route.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Avinash R. Tekade, Sneha U. Mathapati, Mukesh P. Ratnaparkhi, Gajanan M. Kulkarni
Summary: The aim of this study was to enhance the solubility and bioavailability of poorly water-soluble atorvastatin calcium (ATC) using a solid dispersion technique with a natural polymer as a hydrophilic carrier. The results showed that the prepared solid dispersion of ATC using modified Samanea saman seed gum (MSSSG) as the carrier had higher solubility, dissolution rate, and drug release compared to the pure drug. In vivo pharmacokinetic study also demonstrated increased Cmax and AUC values for the solid dispersion formulation.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Article
Biochemistry & Molecular Biology
Iqrar Ahmad, Matin Shaikh, Sanjay Surana, Arabinda Ghosh, Harun Patel
Summary: Third-generation EGFR inhibitors like Osimertinib selectively target EGFR-T790M mutant and have good selectivity for wild-type EGFR. However, after treatment with Osimertinib, a C797S mutation may occur, rendering the tumor undruggable. Recently, trisubstituted imidazoles based on p38 alpha MAPK inhibitors have been developed as fourth-generation EGFR-TKIs to overcome C797S resistance.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Tropical Medicine
Aarti S. Kale, Avinash R. Wadkar, Umesh B. Mahajan, Lalit A. Birari, Sateesh Belemkar, Sameer N. Goyal, Shreesh Ojha, Sanjay J. Surana, Chandragouda R. Patil, Kalpesh R. Patil
Summary: Aloin effectively alleviates chronic constriction injury (CCI)-induced neuropathic pain in rats by reducing mechanical and thermal allodynia, improving motor nerve conduction velocity, decreasing oxidative stress, lowering pro-inflammatory cytokine levels, and restoring the histoarchitecture of compressed sciatic nerve.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2021)
Review
Pharmacology & Pharmacy
Rakesh E. Mutha, Anilkumar U. Tatiya, Sanjay J. Surana
Summary: This review explores the therapeutic potential of natural phenolic compounds, focusing on flavonoids. Long-term intake of dietary foods rich in phenolics has been shown to be protective against various diseases, indicating the potential of phenolics and flavonoids as therapeutic alternatives.
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
