Review
Pharmacology & Pharmacy
Tridib Chaira, Chandru Subramani, Tarani Kanta Barman
Summary: The search for new drugs is time-consuming and expensive, with a significant portion of resources dedicated to generating predictive human pharmacokinetic profiles from animal data. These profiles are crucial for optimizing antiviral drug research and extrapolating human pharmacokinetic parameters from animal profiles.
Article
Medicine, Research & Experimental
Peng Zou
Summary: This study compared the performance of two allometric scaling approaches and a body-weight-based dose conversion approach for dose prediction in gene therapy. The body-weight-based approach underestimated the dose in some vectors, while the allometric scaling approach overestimated the dose. The allometric scaling between log GEF and W-0.25 was appropriate in certain conditions.
MOLECULAR PHARMACEUTICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Suein Choi, Sungpil Han, So Jin Lee, Byunghee Lim, Soo Hyeon Bae, Seunghoon Han, Dong-Seok Yim
Summary: The article introduces a user-friendly open tool named Dall-phinAtoM for predicting human pharmacokinetics. The tool integrates references on PBPK and allometric methods and supports data integration, translation from animal to human, and prediction of concentration-time profiles.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Infectious Diseases
Vincent Aranzana-Climent, Diarmaid Hughes, Sha Cao, Magdalena Tomczak, Malgorzata Urbas, Dorota Zabicka, Carina Vingsbo Lundberg, Jon Hansen, Johan Lindberg, Sven N. Hobbie, Lena E. Friberg
Summary: This study characterized the preclinical pharmacokinetics (PK) and pharmacodynamics of the drug candidate apramycin in fighting carbapenem-resistant gram-negative pathogens. A mathematical model was developed to predict human efficacy based on in vitro and in vivo data. Apramycin showed good lung penetration and the mathematical model integrated lung PK to drive mouse PK and pharmacodynamics. Apramycin was demonstrated as a candidate for treatment of carbapenem-resistant gram-negative pneumonia.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Blazej Pozniak, Marta Tikhomirov, Kamila Bobrek, Pawel Jajor, Marcin Switala
Summary: The study showed that rapid increase in body weight of turkeys could lead to changes in drug pharmacokinetics and age-dependent variability. Non-linear dosage may reduce age-dependent variability in pharmacokinetics, but the low oral bioavailability may limit its effectiveness in turkeys under farm conditions.
Article
Biochemistry & Molecular Biology
Cristiana Correia, Abigail Ferreira, Joana Santos, Rui Lapa, Marjo Yliperttula, Arto Urtti, Nuno Vale
Summary: PK studies are important for dosing regimen design. Combination therapies may be more effective in cancer treatment. In this study, in silico models were used to predict the in vivo performance of drug combinations in cancer therapy, with itraconazole showing the most promising results in combination with reference anticancer drugs.
Article
Chemistry, Medicinal
Lien Thi Ngo, Hwi-yeol Yun, Jung-woo Chae
Summary: This study aimed to predict the drug-drug interaction (DDI) profile of carbamazepine (CBZ) and rivaroxaban (RIV) in humans. Results showed that CBZ significantly reduced RIV exposure, indicating the need for caution when co-administering these drugs, and further studies are necessary to fully understand their safety and effects.
Review
Biochemistry & Molecular Biology
Blaise Pasquiers, Salih Benamara, Mathieu Felices, Laurent Nguyen, Xavier Decleves
Summary: This article discusses the growing interest in therapeutic monoclonal antibodies (mAbs) for various diseases, focusing on their complex pharmacokinetic profiles. It reviews the existing PK modeling approaches to translate mAbs PK from animal models to humans, ranging from empirical models to PBPK models. The emphasis is on population PK methods, linear PK aspects, and TMDD mechanisms of mAbs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Marine
Hans Ulrik Riisgard, Poul S. Larsen
Summary: Demosponges are filter-feeding organisms composed of modular units. The filtration rate of demosponges is related to their size, but the relationship varies depending on the type of sponge. Small single-osculum sponges exhibit a scaling relation between filtration rate and volume, while multi-oscula sponges and large single-osculum sponges have different scaling relationships. The observed decline in volume-specific filtration rate from small to large sizes is discussed.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Pharmacology & Pharmacy
Quanying Bao, Xiaoyi Wang, Bo Wan, Yuan Zou, Yan Wang, Diane J. Burgess
Summary: Long-acting injectable aqueous suspensions achieve extended drug release through slow dissolution of drug crystals. Currently, there are around ten FDA-approved LAI aqueous suspensions, and establishing in vitro-in vivo correlation (IVIVC) for these products is challenging. This study successfully established a Level A IVIVC for LAI aqueous suspensions using in vitro release profiles obtained with USP apparatus 4, which is the first report of an IVIVC for this type of suspension.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Instruments & Instrumentation
Paige N. Zambrana, Dana C. Hammell, Audra L. Stinchcomb
Summary: Due to high variability during clinical pharmacokinetic (PK) evaluation, it has historically been challenging to predict in vivo exposure from in vitro absorption testing of topical semisolid and liquid dermal products. This study aimed to establish accurate in vitro/in vivo correlations (IVIVC) by harmonizing experimental parameters and performed in vivo human serum PK evaluation using excised human skin. The results showed excellent IVIVC for four different sunscreen formulations with controlled application time, occlusion, temperature, and humidity, indicating reduced inter-subject variability and reliable testing of complex topical formulations.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Nicolas Frances, Marina Bacac, Katharine Bray-French, Francois Christen, Heather Hinton, Elisabeth Husar, Elizabeth Quackenbush, Martin Schaefer, Eginhard Schick, Arthur Van de Vyver, Wolfgang F. Richter
Summary: This study presents a novel approach for selecting the first-in-human (FIH) dose of the CD20xCD3 bispecific antibody, glofitamab, based on pharmacokinetic/pharmacodynamic (PKPD) assessment in cynomolgus monkeys. The PKPD model for cytokine release (CR) was used to project a starting dose in humans. The study revealed species-specific clearance and potency differences between cynomolgus monkeys and humans, leading to the selection of a high, safe FIH dose based on IL-6 release.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Soraia Silva, Joana Bicker, Carla Fonseca, Nuno R. Ferreira, Carla Vitorino, Gilberto Alves, Amilcar Falcao, Ana Fortuna
Summary: The study found that nanostructured lipid carriers have the potential to enhance nose-to-brain delivery of antidepressants, reducing systemic and lung exposure and minimizing adverse effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Tibor Dubaj, Katarina Kozics, Monika Sramkova, Alena Manova, Neus G. Bastus, Oscar H. Moriones, Yvonne Kohl, Maria Dusinska, Elise Runden-Pran, Victor Puntes, Andrew Nelson, Alena Gabelova, Peter Simon
Summary: Data for assembling a physiologically-based pharmacokinetic (PBPK) model for nanoparticles (NPs) are relatively scarce, leading to a trend of extrapolating results from in vitro and in silico studies to in vivo nanoparticle hazard and risk assessment. To evaluate the reliability of this approach, a pharmacokinetic study was conducted using the same polyethylene glycol-coated gold nanoparticles (PEG-AuNPs) in vitro and in vivo. The study found notable differences in the internalized amount of Au between individual cell lines and corresponding tissues in vivo, indicating the caution needed when extrapolating in vitro data to predict the in vivo NP burden and response to exposure.
Article
Agriculture, Multidisciplinary
Yanyan Wei, Xiaoman Zheng, Zengyu Zhang, Huanting Liang, Minghua Gu, Fangke Shen, M. J. Shohag, Xiaofeng Li
Summary: The study investigated the correlation between Cd relative bioavailability in rat models and Cd bioaccessibility in four in vitro assays for determining bioavailable Cd amounts in vegetables. It concluded that PBET and IVG were optimal models for Cd-RBA determination in vegetables, and nutritional elements in the vegetables could affect Cd absorption.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Nanoscience & Nanotechnology
Katherine M. Tyner, Peng Zou, Xiaochuan Yang, Hailing Zhang, Celia N. Cruz, Sau L. Lee
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2015)
Review
Pharmacology & Pharmacy
Wenpeng Zhang, Yanyan Li, Peng Zou, Man Wu, Zhenqing Zhang, Tao Zhang
Review
Pharmacology & Pharmacy
Min Li, Peng Zou, Katherine Tyner, Sau Lee
Article
Pharmacology & Pharmacy
Tao Zhang, Yanyan Li, Peng Zou, Jing-yu Yu, Donna McEachern, Shaomeng Wang, Duxin Sun
BIOPHARMACEUTICS & DRUG DISPOSITION
(2013)
Article
Chemistry, Multidisciplinary
Stephan T. Stern, Peng Zou, Sarah Skoczen, Sherwin Xie, Barry Liboiron, Troy Harasym, Paul Tardi, Lawrence D. Mayer, Scott E. McNeil
JOURNAL OF CONTROLLED RELEASE
(2013)
Article
Chemistry, Medicinal
Yujun Zhao, Shanghai Yu, Wei Sun, Liu Liu, Jianfeng Lu, Donna McEachern, Sanjeev Shargary, Denzil Bernard, Xiaoqin Li, Ting Zhao, Peng Zou, Duxin Sun, Shaomeng Wang
JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Article
Chemistry, Medicinal
Peng Zou, Xingrong Liu, Susan Wong, Meihua Rose Feng, Bianca M. Liederer
JOURNAL OF PHARMACEUTICAL SCIENCES
(2013)
Article
Food Science & Technology
Yanyan Li, Tao Zhang, Xiaoqin Li, Peng Zou, Steven J. Schwartz, Duxin Sun
MOLECULAR NUTRITION & FOOD RESEARCH
(2013)
Article
Medicine, Research & Experimental
Peng Zou, Lawrence Helson, Anirban Maitra, Stephan T. Stern, Scott E. McNeil
MOLECULAR PHARMACEUTICS
(2013)
Article
Medicine, Research & Experimental
Peng Zou, Hongwei Chen, Hayley J. Paholak, Duxin Sun
MOLECULAR PHARMACEUTICS
(2013)
Article
Chemistry, Multidisciplinary
Peng Zou, Stephan T. Stern, Duxin Sun
PHARMACEUTICAL RESEARCH
(2014)
Review
Pharmacology & Pharmacy
Peng Zou, Katherine Tyner, Andre Raw, Sau Lee
Article
Pharmacology & Pharmacy
Katherine M. Tyner, Nan Zheng, Stephanie Choi, Xiaoming Xu, Peng Zou, Wenlei Jiang, Changning Guo, Celia N. Cruz
Review
Pharmacology & Pharmacy
Nan Zheng, Dajun D. Sun, Peng Zou, Wenlei Jiang