Article
Medicine, Research & Experimental
Saikat Ghosh, Nicholas L. Fletcher, Pie Huda, Zachary H. Houston, Christopher B. Howard, Maria E. Lund, Yanling Lu, Douglas H. Campbell, Bradley J. Walsh, Kristofer J. Thurecht
Summary: This study developed an antibody-based positron emission tomography (PET) tracer for noninvasive detection of glypican-1 (GPC-1) positive glioblastoma (GBM) tumors. The results show that 89Zr-DFO-Miltuximab is an effective immuno-PET imaging agent for detecting GPC-1positive tumors such as GBM.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Briana Macedo, Manthan Patel, Michael H. Zaleski, Parth Mody, Xiaonan Ma, Patrick Mei, Jacob W. Myerson, Jacob S. Brenner, Patrick M. Glassman
Summary: Thorough characterization of nanoparticle-based drug delivery systems' plasma pharmacokinetics (PK) is critical for clinical development. A meta-analysis of 100 nanoparticle formulations in mice was conducted to identify correlations between PK parameters and nanoparticle properties. Single linear regressions between properties and PK parameters showed poor predictability, while multivariate regressions showed improved predictability. Improved reporting of nanoparticle properties will enhance our ability to predict in vivo behavior and design optimal nanoparticles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Hsuan-Ping Chang, Se Jin Kim, Dhaval K. Shah
Summary: This study reports the whole-body disposition of wild-type IgG and FcRn non-binding IgG in mice, determined using ELISA. The concept of ABCIS values, the comparison with previously published biodistribution data, and the refinement of PBPK model for mAbs using the new set of biodistribution data generated using ELISA are highlighted in this study.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Syed Muhammad Usama, Sierra C. Marker, Donald R. Caldwell, Nimit L. Patel, Yang Feng, Joseph D. Kalen, Brad St Croix, Martin J. Schnermann
Summary: ADCs are an important therapeutic platform, where the linker between antibodies and drug payloads greatly affects efficacy and tolerability. A new NIR imaging method has been developed to quantitatively assess linker cleavage efficiency, enabled by an improved variant of the CyBam platform. Furthermore, different linkers were compared across antibodies and tumor models, revealing that cathepsin-cleavable linkers show higher tumor activation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Mathematics, Interdisciplinary Applications
Sinenhlanhla Mtshali, Byron A. A. Jacobs
Summary: This study aimed to validate the use of fractional order differential equations for certain drug regimes in pharmacokinetics. Two numerical methods were implemented and verified through the method of manufactured solutions. The model, derived from a phenomenological process, provides a dimensionally consistent and physically meaningful representation. Clinical data validated the model and showed that a fractional order is optimal for clearance dynamics in certain drug regimes, supporting the hypothesis that fractional differential equations better describe pharmacokinetics.
FRACTAL AND FRACTIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Rita M. Pinto, Saleh Yazdani, Catarina Leal Seabra, Martine De Jonge, Mukaddes Izci, Rebeca Cruz, Susana Casal, Stefaan J. Soenen, Salette Reis, Claudia Nunes, Patrick Van Dijck
Summary: Staphylococcus aureus is a high priority pathogen due to its prevalence and ability to form biofilms. Current treatments do not target the matrix that contributes to antimicrobial tolerance. This study proposes the use of lipid nanoparticles encapsulating caspofungin to disrupt the matrix, and combining them with moxifloxacin-loaded nanoparticles to reduce biofilms. In vitro and in vivo studies showed promising results, with reduced biofilm formation and no bacterial dissemination into vital organs.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Agriculture, Multidisciplinary
Paula S. Ferreira, John A. Manthey, Marina S. Nery, Thais B. Cesar
Summary: The study demonstrated the metabolism and distribution of orally administered eriocitrin in rats for the first time, identifying multiple metabolites in rat urine and tissues, with homoeriodictyol and homoeriodictyol-7-O-glucuronide as the major metabolites. The half-lives of metabolites in plasma were approximately 3 to 3.2 hours, and the total bioavailability of eriocitrin was less than 1%.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Vincent Mittelheisser, Pierre Coliat, Eric Moeglin, Lilian Goepp, Jacky G. Goetz, Loic J. Charbonniere, Xavier Pivot, Alexandre Detappe
Summary: Tumor-targeted antibody/fragment-conjugated nanoparticles show promise in improving local delivery of small molecules. A meta-analysis of 161 studies confirmed that targeted nanoparticles had significantly higher tumor uptake compared to naked nanoparticles. The study also found that the choice of nanoparticle type, size, and antibody moiety affected tumor uptake.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Fei Wang, Ling Sum Liu, Pan Li, Cia Hin Lau, Hoi Man Leung, Y. Rebecca Chin, Chung Tin, Pik Kwan Lo
Summary: Compared with siRNAs or other ASOs, TNA has the advantages of chemical simplicity, DNA/RNA binding capability, folding ability of tertiary structure, and excellent physiological stability, which make it a promising tool in biomedical applications. This study investigates the pharmacokinetics and biosafety of TNAs in living organisms, finding that they exhibit excellent stability, low cytotoxicity, and substantial uptake in living cells without transfection. TNAs also show the ability to efficiently penetrate multicellular spheroids and can be safely administered in mice without causing pathological changes in the kidneys.
MATERIALS TODAY BIO
(2022)
Review
Immunology
Million A. Tegenge, Iftekhar Mahmood, Evi B. Struble, Zuben Sauna
Summary: Pharmacokinetics (PK) studies are crucial for determining safe and effective dosages of both small and large molecule drugs. While PK studies have been conducted for small molecules during pregnancy, there is limited research on macromolecules such as monoclonal and polyclonal antibodies. This review provides an overview of macromolecule drugs and their PK differences compared to small molecules, as well as the physiological changes during pregnancy. Further investigations are needed to fully understand the impact of pregnancy on PK properties of macromolecules.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Imran Rather, Nusrat Shafiq, Jaya Shukla, Gurvinder Kaur, Somit Pandey, Ritika Kondel Bhandari, Avaneesh Kumar Pandey, B. R. Mittal, G. K. Khuller, Navneet Sharma, Samir Malhotra
Summary: This study explores the pharmacokinetics and biodistribution of poly(lactic-co-glycolic) acid (PLGA) nanoparticles in healthy human volunteers. The results show significant differences in pharmacokinetic parameters between the nanoparticle and conventional groups, with the nanoparticles mainly distributed in the distal portions of the intestine, making them potentially advantageous for the treatment of intestinal or lymph node tuberculosis.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu-Chuen Huang, Pei-Ying Hsieh, Li-Ying Wang, Tung-Hu Tsai, Yu-Jen Chen, Chen-Hsi Hsieh
Summary: The aim of this study was to evaluate the radiotherapy (RT)-pharmacokinetics (PK) effect of cabozantinib in concurrent or sequential regimens with external beam radiotherapy (EBRT) or stereotactic body radiation therapy (SBRT). The RT-drug interactions of cabozantinib under RT were confirmed in a free-moving rat model. The biodistribution of cabozantinib in the heart is modulated by off-target irradiation and SBRT doses simultaneously.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Anna Maria Tolomeo, Gaia Zuccolotto, Ricardo Malvicini, Giada De Lazzari, Alessandro Penna, Chiara Franco, Federico Caicci, Fabio Magarotto, Santina Quarta, Michela Pozzobon, Antonio Rosato, Maurizio Muraca, Federica Collino
Summary: This study aimed to evaluate the biodistribution of MSC-EVs after different routes of administration in mice. Results showed that local administration could increase the concentration of EVs in selective organs, limiting their systemic distribution and potentially reducing extra-organ effects. Biodistribution studies can help in selecting the most appropriate way of administering MSC-EVs for treating different diseases.
Article
Oncology
Hanine Rafidi, Alberto Estevez, Gregory Z. Ferl, Danielle Mandikian, Shannon Stainton, Lauren Sermeno, Simon P. Williams, Amrita Kamath, James T. Koerber, C. Andrew Boswell
Summary: Advances in antibody engineering have allowed the construction of novel molecular formats, providing new opportunities for cancer immunotherapy drug discovery, but also revealing limitations in knowledge of structure-activity relationships. By constructing a representative library and using different shapes and hinge flexibilities of IgG-like formats, it was found that one-armed antibodies have higher renal uptake compared to bivalent antibodies.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Jiayi Zhu, Zhipeng Zhao, Huarui Chen, Xinglin Chen, Jinbin Liu
Summary: This study demonstrates that renal-clearable nanomedicines show a more sensitive response to injection dose and have improved tumor-targeting efficiency compared to nonrenal-clearable nanoparticles.
Article
Biochemistry & Molecular Biology
Daniela Bumbaca Yadav, Vikas K. Sharma, Charles Andrew Boswell, Isidro Hotzel, Devin Tesar, Yonglei Shang, Yong Ying, Saloumeh K. Fischer, Jane L. Grogan, Eugene Y. Chiang, Konnie Urban, Sheila Ulufatu, Leslie A. Khawli, Saileta Prabhu, Sean Joseph, Robert F. Kelley
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Neurosciences
Nga Bien-Ly, C. Andrew Boswell, Surinder Jeet, Thomas G. Beach, Kwame Hoyte, Wilman Luk, Vera Shihadeh, Sheila Ulufatu, Oded Foreman, Yanmei Lu, Jason DeVoss, Marcel van der Brug, Ryan J. Watts
Article
Medicine, Research & Experimental
Rong Deng, Daniela Bumbaca, Cinthia V. Pastuskovas, C. Andrew Boswell, David West, Kyra J. Cowan, Henry Chiu, Jacqueline McBride, Clarissa Johnson, Yan Xin, Hartmut Koeppen, Maya Leabman, Suhasini Iyer
Article
Medicine, Research & Experimental
Sharmila Rajan, Danielle Mandikian, Amos Baruch, Thomas R. Gelzleichter, Dale Stevens, Junichiro Sonoda, Kyra Cowan, C. Andrew Boswell, Eric Stefanich
Article
Oncology
Danielle Mandikian, Nene Takahashi, Amy A. Lo, Ji Li, Jeffrey Eastham-Anderson, Dionysos Slaga, Jason Ho, Maria Hristopoulos, Robyn Clark, Klara Totpal, Kedan Lin, Sean B. Joseph, Mark S. Dennis, Saileta Prabhu, Teemu T. Junttila, C. Andrew Boswell
MOLECULAR CANCER THERAPEUTICS
(2018)
Article
Multidisciplinary Sciences
Sara L. Dominguez, Ganapati V. Hegde, Jesse E. Hanson, Hong Xiang, Danielle Mandikian, C. Andrew Boswell, Cecilia Chiu, Yan Wu, Siao Ping Tsai, Daniel Fleck, Martin Weber, Hai Ngu, Kimberly Scearce-Levie, Erica L. Jackson
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Nga Bien-Ly, Y. Joy Yu, Daniela Bumbaca, Justin Elstrott, C. Andrew Boswell, Yin Zhang, Wilman Luk, Yanmei Lu, Mark S. Dennis, Robby M. Weimer, Inhee Chung, Ryan J. Watts
JOURNAL OF EXPERIMENTAL MEDICINE
(2014)
Article
Medicine, Research & Experimental
Amrita V. Kamath, Victor Yip, Priyanka Gupta, C. Andrew Boswell, Daniela Bumbaca, Peter Haughney, Joni Castro, Siao Ping Tsai, Glenn Pacheco, Sarajane Ross, Minhong Yan, Lisa A. Damico-Beyer, Leslie Khawli, Ben-Quan Shen
Article
Medicine, Research & Experimental
Victor Yip, Enzo Palma, Devin B. Tesar, Eduardo E. Mundo, Daniela Bumbaca, Elizabeth K. Torres, Noe A. Reyes, Ben Q. Shen, Paul J. Fielder, Saileta Prabhu, Leslie A. Khawli, C. Andrew Boswell
Article
Medicine, Research & Experimental
Danielle Mandikian, Hanine Rafidi, Pragya Adhikari, Priya Venkatraman, Lidia Nazarova, Gabriel Fung, Isabel Figueroa, Gregory Z. Ferl, Sheila Ulufatu, Jason Ho, Cynthia McCaughey, Jeffrey Lau, Shang-Fan Yu, Saileta Prabhu, Jack Sadowsky, C. Andrew Boswell
Article
Pharmacology & Pharmacy
Danielle Mandikian, Isabel Figueroa, Amy Oldendorp, Hanine Rafidi, Sheila Ulufatu, Michelle G. Schweiger, Jessica A. Couch, Noel Dybdal, Sean B. Joseph, Saileta Prabhu, Gregory Z. Ferl, C. Andrew Boswell
Article
Medicine, Research & Experimental
T. Noelle Lombana, Sharmila Rajan, Julie A. Zorn, Danielle Mandikian, Eugene C. Chen, Alberto Estevez, Victor Yip, Daniel D. Bravo, Wilson Phung, Farzam Farahi, Sharon Viajar, Sophia Lee, Avinash Gill, Wendy Sandoval, Jianyong Wang, Claudio Ciferri, C. Andrew Boswell, Marissa L. Matsumoto, Christoph Spiess
Article
Biochemical Research Methods
Amin Famili, Susan R. Crowell, Kelly M. Loyet, Danielle Mandikian, C. Andrew Boswell, David Cain, Joyce Chan, Laetitia Comps-Agrar, Amrita Kamath, Karthikan Rajagopal
BIOCONJUGATE CHEMISTRY
(2019)
Article
Oncology
Hanine Rafidi, Alberto Estevez, Gregory Z. Ferl, Danielle Mandikian, Shannon Stainton, Lauren Sermeno, Simon P. Williams, Amrita Kamath, James T. Koerber, C. Andrew Boswell
Summary: Advances in antibody engineering have allowed the construction of novel molecular formats, providing new opportunities for cancer immunotherapy drug discovery, but also revealing limitations in knowledge of structure-activity relationships. By constructing a representative library and using different shapes and hinge flexibilities of IgG-like formats, it was found that one-armed antibodies have higher renal uptake compared to bivalent antibodies.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Ophthalmology
Leslie J. Dickmann, Victor Yip, Cuiwen Li, Juan Abundes, Mauricio Maia, Cynthia Young, Shannon Stainton, Philip E. Hass, Sean B. Joseph, Saileta Prabhu, C. Andrew Boswell
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)