Article
Plant Sciences
Shasha Qin, Jingzhuo Tian, Yong Zhao, Lianmei Wang, Jinyu Wang, Suyan Liu, Jing Meng, Fang Wang, Chenyue Liu, Jiayin Han, Chen Pan, Yushi Zhang, Yan Yi, Chunying Li, Meiting Liu, Aihua Liang
Summary: This study aims to systematically elucidate the mechanism by which Gardenia extract ameliorates ANIT-induced cholestatic liver injury.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Gastroenterology & Hepatology
Tengqi Ren, Liwei Pang, Wanlin Dai, Shuodong Wu, Jing Kong
Summary: The bile salt export pump (BSEP/ABCB11) plays a crucial role in bile salt secretion by controlling the efflux of bile salts from hepatocytes into the bile. Research efforts have been focused on understanding the physiological and pathological functions and regulatory mechanisms of BSEP. Several liver diseases have been linked to BSEP expression and dysfunction.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Review
Medicine, General & Internal
Maciej Majsterek, Magdalena Wierzchowska-Opoka, Inga Makosz, Lena Kreczynska, Zaneta Kimber-Trojnar, Bozena Leszczynska-Gorzelak
Summary: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-related condition characterized by elevated levels of bile acids (BAs) in blood serum and an increased risk of adverse perinatal outcomes. Early diagnosis and prompt management based on BA levels are crucial in reducing fetal complications.
Review
Obstetrics & Gynecology
Antonio F. Saad, Luis D. Pacheco, Lucy Chappell, George R. Saade
Summary: ICP is associated with poor perinatal outcomes in some women, but recent evidence shows that UDCA may not have a significant impact on most perinatal outcomes, therefore a comprehensive approach is needed to manage ICP effectively.
REPRODUCTIVE SCIENCES
(2022)
Article
Medicine, General & Internal
Roberta Granese, Gloria Calagna, Angela Alibrandi, Canio Martinelli, Paola Romeo, Roberto Filomia, Maria Immacolata Ferraro, Eleonora Piccione, Alfredo Ercoli, Carlo Saitta
Summary: The study aimed to evaluate the outcomes of intrahepatic cholestasis of pregnancy (ICP) on both maternal and fetal health. A retrospective case-control study was conducted, including pregnant women diagnosed with ICP between January 2010 and December 2020 at a university hospital. The results showed a higher incidence of hypothyroidism, thrombophilia, gestational diabetes, gestational hypertension, postpartum hemorrhage, and preterm delivery in ICP patients compared to the control group. However, there were no recorded neonatal adverse events and no signs of chronic liver disease in ICP patients during the 24-month follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Qiong Pan, Gang Luo, Jiaquan Qu, Sheng Chen, Xiaoxun Zhang, Nan Zhao, Jingjing Ding, Hong Yang, Mingqiao Li, Ling Li, Ying Cheng, Xuan Li, Qiaoling Xie, Qiao Li, Xueqian Zhou, Huiling Zou, Shijun Fan, Lingyun Zou, Wei Liu, Guohong Deng, Shi-Ying Cai, James L. Boyer, Jin Chai
Summary: The homozygous mutation of SEMA7A(R145W) leads to intrahepatic cholestasis in both mice and children, with further studies showing that this mutation affects the expression of hepatic bile acid transporters and export pumps.
EMBO MOLECULAR MEDICINE
(2021)
Article
Genetics & Heredity
Yong Shao, Siyu Chen, Huan Li, Qin Tang, Di Xu
Summary: Maternal serum bile acid profiles are useful in differentiating the four subtypes of ICP. ICP with jaundice may serve as an important predictor of adverse pregnancy outcomes of ICP.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Gastroenterology & Hepatology
Duc-Hung Pham, Ramesh Kudira, Lingfen Xu, C. Alexander Valencia, Jillian L. Ellis, Tiffany Shi, Kimberley J. Evason, Immaculeta Osuji, Nelson Matuschek, Liva Pfuhler, Mary Mullen, Sujit K. Mohanty, Ammar Husami, Laura N. Bull, Kejian Zhang, Sami Wali, Chunyue Yin, Alexander Miethke
Summary: In this study, variants in the ABCC12 gene were discovered in children with chronic cholestasis, shedding light on a potential link between MRP9 and bile duct homeostasis and cholestatic liver disease. Utilizing zebrafish and murine models, it was demonstrated that MRP9 deficiency can lead to cholangiocyte injury and progressive bile duct loss, indicating a possible therapeutic target for bile acid-induced cholangiocyte injury.
Article
Biochemistry & Molecular Biology
Edgar Ontsouka, Alessandra Epstein, Sampada Kallol, Jonas Zaugg, Marc Baumann, Henning Schneider, Christiane Albrecht
Summary: The study found significant alterations in placental SLCO3A1 (OATP3A1) gene expression in patients with intrahepatic cholestasis of pregnancy (ICP), while the expression levels of the other 20 genes were comparable between healthy and ICP placentae. Additionally, certain genes in ICP placentae showed positive correlations with BA concentrations and maternal body mass index.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Zhuoqiao Yang, Mengxin Yao, Chunhua Zhang, Xuan Hu, Yi Zhong, Xiangxiang Xu, Jieyun Yin
Summary: This study reviewed metabolomics studies related to intrahepatic cholestasis of pregnancy (ICP), revealing dysregulation of bile acid metabolism and lipid metabolism. Metabolomics shows potential for the diagnosis of ICP.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Letter
Genetics & Heredity
Elodie Mareux, Martine Lapalus, Amel Ben-Saad, Isabelle Callebaut, Thomas Falguieres, Emmanuel Gonzales, Emmanuel Jacquemin
Summary: The study found that the ABCB11 p.A257V variant exhibits varying functional defects in different cells in vitro, and this defect can be fully rescued by Ivacaftor. This suggests that Ivacaftor may be an effective pharmacological tool for patients with ICP and PFIC2 caused by ABCB11 variations affecting ABCB11 function.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Gastroenterology & Hepatology
Lauren E. E. Lynch, Amy B. B. Hair, Krishnakant G. G. Soni, Heeju Yang, Laura A. A. Gollins, Monica Narvaez-Rivas, Kenneth D. R. Setchell, Geoffrey A. A. Preidis
Summary: Cholestasis refers to impaired bile flow from the liver to the intestine. In neonates, cholestasis causes poor growth and may progress to liver failure and death. This study examined the development of the liver-gut-microbiome axis and the effects of cholestasis on this development in extremely preterm infants. The results showed that cholestasis interrupts the development of the secondary bile acid biosynthesis pathway and bile salt hydrolase genes, which are important for normal bile flow.
Article
Pharmacology & Pharmacy
Chang Hun Lee, Yunjung Choi, Hyewon Cho, In Hyuk Bang, Lihua Hao, Seung-Ok Lee, Raok Jeon, Eun Ju Bae, Byung-Hyun Park
Summary: The synthesized HDAC8 inhibitor SPA3014 demonstrated therapeutic efficacy against cholestatic liver injury and fibrosis in mice, suggesting its potential as a new therapeutic strategy for cholestatic liver disease.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Obstetrics & Gynecology
Rebecca Horgan, Christiana Bitas, Alfred Abuhamad
Summary: This study compared the guidelines for the diagnosis, antepartum surveillance, and timing of delivery of pregnancies complicated by intrahepatic cholestasis of pregnancy published by the Society for Maternal-Fetal Medicine and the Royal College of Obstetricians and Gynaecologists. The two organizations have several key differences in their clinical guidelines, including the criteria for diagnosing intrahepatic cholestasis of pregnancy and the recommended treatments. The Society for Maternal-Fetal Medicine recommends fetal surveillance and specific delivery timing based on bile acid levels, while the Royal College of Obstetricians and Gynaecologists does not recommend additional fetal testing beyond kick count assessment and stratifies delivery timing based on bile acid levels.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
Siming Xin, Xianxian Liu, Huai Liu, Xiaoming Zeng, Ying Xiong, Mengni Zhou, Yang Zou, Yang Zeng, Jiusheng Zheng, Hua Lai
Summary: This study discovered CYP27A1 gene mutations in Chinese women with ICP, which were found to affect TBA and CHOL levels, leading to the occurrence of ICP.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Correction
Biochemistry & Molecular Biology
Jeff S. Piotrowski, Sheena C. Li, Raamesh Deshpande, Scott W. Simpkins, Justin Nelson, Yoko Yashiroda, Jacqueline M. Barber, Hamid Safizadeh, Erin Wilson, Hiroki Okada, Abraham A. Gebre, Karen Kubo, Nikko P. Torres, Marissa A. LeBlanc, Kerry Andrusiak, Reika Okamoto, Mami Yoshimura, Eva DeRango-Adem, Jolanda van Leeuwen, Katsuhiko Shirahige, Anastasia Baryshnikova, Grant W. Brown, Hiroyuki Hirano, Michael Costanzo, Brenda Andrews, Yoshikazu Ohya, Hiroyuki Osada, Minoru Yoshida, Chad L. Myers, Charles Boone
NATURE CHEMICAL BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Jeff S. Piotrowski, Sheena C. Li, Raamesh Deshpande, Scott W. Simpkins, Justin Nelson, Yoko Yashiroda, Jacqueline M. Barber, Hamid Safizadeh, Erin Wilson, Hiroki Okada, Abraham A. Gebre, Karen Kubo, Nikko P. Torres, Marissa A. LeBlanc, Kerry Andrusiak, Reika Okamoto, Mami Yoshimura, Eva DeRango-Adem, Jolanda Van Leeuwen, Katsuhiko Shirahige, Anastasia Baryshnikova, Grant W. Brown, Hiroyuki Hirano, Michael Costanzo, Brenda Andrews, Yoshikazu Ohya, Hiroyuki Osada, Minoru Yoshida, Chad L. Myers, Charles Boone
NATURE CHEMICAL BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Manabu Kaneko, Yushi Futamura, Senko Tsukuda, Yasumitsu Kondoh, Tomomi Sekine, Hiroyuki Hirano, Kento Fukano, Hirofumi Ohashi, Wakana Saso, Ryo Morishita, Satoko Matsunaga, Fumihiro Kawai, Akihide Ryo, Sam-Yong Park, Ryosuke Suzuki, Hideki Aizaki, Naoko Ohtani, Camille Sureau, Takaji Wakita, Hiroyuki Osada, Koichi Watashi
SCIENTIFIC REPORTS
(2018)
Review
Pharmacology & Pharmacy
Hikaru Saito, Ran An, Hiroyuki Hirano, Toshihisa Ishikawa
DRUG METABOLISM AND PHARMACOKINETICS
(2010)
Review
Chemistry, Medicinal
T. Ishikawa, H. Hirano, H. Saito, K. Sano, Y. Ikegami, N. Yamaotsu, S. Hirono
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2012)
Review
Pharmacology & Pharmacy
Toshihisa Ishikawa, Aki Sakurai, Hiroyuki Hirano, Alexander Lezhava, Minoru Sakurai, Yoshihide Hayashizaki
PHARMACOLOGY & THERAPEUTICS
(2010)
Article
Multidisciplinary Sciences
Naoki Kanoh, Ayano Kawamata-Asano, Kana Suzuki, Yusuke Takahashi, Takeshi Miyazawa, Takemichi Nakamura, Takashi Moriya, Hiroyuki Hirano, Hiroyuki Osada, Yoshiharu Iwabuchi, Shunji Takahashi
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Kaori Sako, Yushi Futamura, Takeshi Shimizu, Akihiro Matsui, Hiroyuki Hirano, Yasumitsu Kondoh, Makoto Muroi, Harumi Aono, Maho Tanaka, Kaori Honda, Kenshirou Shimizu, Makoto Kawatani, Takeshi Nakano, Hiroyuki Osada, Ko Noguchi, Motoaki Seki
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Nicole M. Revie, Kali R. Iyer, Michelle E. Maxson, Jiabao Zhang, Su Yan, Caroline M. Fernandes, Kirsten J. Meyer, Xuefei Chen, Iwona Skulska, Meea Fogal, Hiram Sanchez, Saif Hossain, Sheena Li, Yoko Yashiroda, Hiroyuki Hirano, Minoru Yoshida, Hiroyuki Osada, Charles Boone, Rebecca S. Shapiro, David R. Andes, Gerard D. Wright, Justin R. Nodwell, Maurizio Del Poeta, Martin D. Burke, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Summary: A compound is identified that synergizes with antifungals, inhibiting biofilm formation and virulence traits of Candida albicans.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Megumi Aoyama, Kosuke Ishikawa, Shuntaro Nemoto, Hiroyuki Hirano, Nobumoto Watanabe, Hiroyuki Osada, Shinya Watanabe, Kentaro Semba
Summary: This study establishes a system to evaluate the cancer-inhibitory activity of surrounding nontransformed cells and identifies lonidamine and domperidone as compounds that can inhibit the expansion of oncogenic foci. The findings suggest that these compounds suppress the movement of nontransformed cells and promote stress fiber formation, potentially leading to the development of a new type of drug that induces the anticancer activity of surrounding non-transformed cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Virology
Hirotaka Sato, Jun-na Fukui, Hiroyuki Hirano, Hiroyuki Osada, Yutaka Arimura, Michiaki Masuda, Yoko Aida
Summary: Bovine leukemia virus (BLV) infection causes bovine leukemia and lymphoma, leading to economic losses. We developed the luminescence syncytium induction assay (LuSIA) to study BLV infection. LuSIA was used to screen drugs and identified BSI-625 and -679 as potent inhibitors of BLV replication with low cytotoxicity. LuSIA may be useful for the development of anti-BLV drugs.
Article
Biochemical Research Methods
Justin Nelson, Scott W. Simpkins, Hamid Safizadeh, Sheena C. Li, Jeff S. Piotrowski, Hiroyuki Hirano, Yoko Yashiroda, Hiroyuki Osada, Minoru Yoshida, Charles Boone, Chad L. Myers
Article
Biochemistry & Molecular Biology
Aki Sakurai, Yuko Onishi, Hiroyuki Hirano, Michel Seigneuret, Kazuya Obanayama, Gunwoo Kim, Ei Leen Liew, Toshiyuki Sakaeda, Koh-ichiro Yoshiura, Norio Niikawa, Minoru Sakurai, Toshihisa Ishikawa
Meeting Abstract
Pharmacology & Pharmacy
Hikaru Saito, Hiroyuki Hirano, Shuichi Hirono, Daisuke Tokushima, Toshihisa Ishikawa
DRUG METABOLISM REVIEWS
(2007)