期刊
NATURE BIOMEDICAL ENGINEERING
卷 2, 期 2, 页码 104-113出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41551-018-0191-4
关键词
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资金
- Stanford Bio-X
- National Institutes of Health [HL133272, HL132875, 113006, EB009035, HL134830-01]
- California Institute of Regenerative Medicine (CIRM) [DR2-05394, RT3-07798]
Stem-cell-based therapies hold considerable promise for regenerative medicine. However, acute donor-cell death within several weeks after cell delivery remains a critical hurdle for clinical translation. Co-transplantation of stem cells with pro-survival factors can improve cell engraftment, but this strategy has been hampered by the typically short half-lives of the factors and by the use of Matrigel and other scaffolds that are not chemically defined. Here, we report a collagen-dendrimer biomaterial crosslinked with pro-survival peptide analogues that adheres to the extracellular matrix and slowly releases the peptides, significantly prolonging stem cell survival in mouse models of ischaemic injury. The biomaterial can serve as a generic delivery system to improve functional outcomes in cell-replacement therapy.
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