Article
Cardiac & Cardiovascular Systems
James D. Theuerle, Ali H. Al-Fiadh, Fakir M. Amirul Islam, Sheila K. Patel, Louise M. Burrell, Tien Yin Wong, Omar Farouque
Summary: Assessing retinal microvascular endothelial dysfunction can predict long-term cardiovascular events. Retinal arteriolar dysfunction is an independent predictor of MACE in patients with CAD. Dynamic retinal vessel analysis may enhance risk stratification for cardiovascular events.
CARDIOVASCULAR RESEARCH
(2021)
Article
Physiology
Anna E. Stanhewicz, Rowan L. Schlarmann, Kaila M. Brustkern, Diana I. Jalal
Summary: The study demonstrates that women who have had gestational diabetes during pregnancy are at higher risk for cardiovascular disease and type 2 diabetes in the decade following pregnancy. Microvascular dysfunction, mediated by increased oxidative stress, persists after pregnancy in women who had gestational diabetes.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Toria Tomasek, Lorraine B. Ware, Julie A. Bastarache, Jamie E. Meegan
Summary: Circulating cell-free hemoglobin (CFH) contributes to endothelial injury in various inflammatory and hemolytic conditions, but does not lead to endothelial barrier dysfunction through cell death mechanisms. Despite causing a decrease in cell viability over time, CFH does not increase apoptosis and cannot be prevented by inhibitors of various cell death pathways, indicating that cell death does not play a role in CFH-mediated lung microvascular endothelial barrier dysfunction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Changcheng Zhou, Jiani Bei, Yuan Qiu, Qing Chang, Emmanuel Nyong, Nikos Vasilakis, Jun Yang, Balaji Krishnan, Kamil Khanipov, Yang Jin, Xiang Fang, Angelo Gaitas, Bin Gong
Summary: Spotted fever group rickettsioses caused by Rickettsia (R) can induce lethal endothelial cell barrier dysfunction. Exosomes derived from infected endothelial cells can impair the barrier function of normal recipient cells by delivering miR23a, which targets the TJ protein ZO-1 mRNA.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Fujie Zhao, Ganesh Satyanarayana, Zheng Zhang, Jianli Zhao, Xin-Liang Ma, Yajing Wang
Summary: Coronary microvascular dysfunction is a type of abnormality in coronary microcirculation that leads to impaired coronary blood flow and myocardial ischemia, associated with various cardiovascular diseases. Insufficient or uncontrolled activation of endothelial autophagy plays a significant role in the pathogenesis of CMD.
Review
Cardiac & Cardiovascular Systems
Filippo Crea, Rocco A. Montone, Riccardo Rinaldi
Summary: Ischemic heart disease is commonly caused by coronary artery disease, but a significant number of patients may experience angina or myocardial infarction even without significant coronary artery stenosis. Coronary microvascular dysfunction has been identified as a relevant cause, involving functional and structural changes in the coronary microcirculation. Modifiable risk factors play a role in the pathogenesis, and further research is needed to develop precision medicine strategies.
CIRCULATION JOURNAL
(2022)
Article
Biology
I. -Fan Liu, Tzu-Chieh Lin, Shu-Chi Wang, Chia-Hung Yen, Chia-Yang Li, Hsuan-Fu Kuo, Chong-Chao Hsieh, Chia-Yuan Chang, Chuang-Rung Chang, Yung-Hsiang Chen, Yu-Ru Liu, Tsung-Ying Lee, Chi-Yuan Huang, Chih-Hsin Hsu, Shing-Jong Lin, Po-Len Liu
Summary: Long-term consumption of excessive fat and sucrose diet can lead to metabolic syndrome and cardiovascular disease. The study found that CAV-1 and caveolae proteins are related to abnormal lipid accumulation in the endothelium and myocardium, as well as dysfunction in microvascular endothelial cells and mitochondrial remodeling.
Review
Biology
Stamatina Lamprou, Nikolaos Koletsos, Gesthimani Mintziori, Panagiota Anyfanti, Christina Trakatelli, Vasileios Kotsis, Eugenia Gkaliagkousi, Areti Triantafyllou
Summary: Prediabetes is a significant metabolic state with high potential for progression to diabetes. People with prediabetes have an increased risk of cardiovascular disease and mortality. Microvascular and endothelial dysfunction in peripheral organs and tissues can be detected and monitored, and are currently being studied as markers of subclinical and future cardiovascular disease in prediabetes.
Article
Neurosciences
Jiani Bei, Ernesto G. Miranda-Morales, Qini Gan, Yuan Qiu, Sorosh Husseinzadeh, Jia Yi Liew, Qing Chang, Balaji Krishnan, Angelo Gaitas, Subo Yuan, Michelle Felicella, Wei Qiao Qiu, Xiang Fang, Bin Gong
Summary: This study found that exosomes from AD patients can cause dysfunction in brain endothelial cells by damaging adherens junction proteins. These findings highlight the significant role of circulating exosomes from AD patients in the progression of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Jingwei Li, Yun Zhou, Jiechao Ma, Qin Zhang, Jun Shao, Shufan Liang, Yizhou Yu, Weimin Li, Chengdi Wang
Summary: COVID-19 may lead to long-term symptoms in multiple systems, referred to as long COVID, and can impact patients of varying severity. This comprehensive review highlights the epidemiology, impact of vaccinations, organ-specific sequelae, pathophysiological mechanisms, and multidisciplinary management strategies of long COVID, with emphasis on psychological and psychosomatic factors. Current diagnostic and therapeutic strategies are inadequate, and further clinical trials are needed to validate existing hypotheses.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Biology
Zahra Shabani, Jialing Liu, Hua Su
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory system but can also cause neurological symptoms and cognitive difficulties. These complications can last for months after infection, disrupting daily life. This review summarizes the current understanding of the effects of COVID-19 on vascular dysfunction and how it leads to cognitive impairment.
Article
Cardiac & Cardiovascular Systems
Roberto Scarsini, Mayooran Shanmuganathan, Giovanni Luigi De Maria, Alessandra Borlotti, Rafail A. Kotronias, Matthew K. Burrage, Dimitrios Terentes-Printzios, Jeremy Langrish, Andrew Lucking, Gregor Fahrni, Florim Cuculi, Flavio Ribichini, Robin P. Choudhury, Rajesh Kharbanda, Vanessa M. Ferreira, Keith M. Channon, Adrian P. Banning
Summary: This study found that coronary microvascular dysfunction is associated with an increased long-term risk of adverse cardiovascular events, particularly heart failure. Using either IMR or CMR to assess CMD showed similar risk of adverse outcomes.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Nutrition & Dietetics
Amitai Segev, Michael Shechter, Avishai M. Tsur, David Belkin, Hofit Cohen, Amir Sharon, Nira Koren Morag, Ehud Grossman, Elad Maor
Summary: This study evaluated the association between serum magnesium levels on admission and clinical outcomes in hospitalized non-ST-elevation myocardial infarction patients. The results showed that low serum magnesium was independently associated with higher long-term mortality risk. This suggests that low serum magnesium may be a potential factor for poor prognosis in cardiovascular disease patients.
Article
Health Care Sciences & Services
Thomas L. Maurissen, Georgios Pavlou, Colette Bichsel, Roberto Villasenor, Roger D. Kamm, Heloise Ragelle
Summary: Blood-neural barriers are crucial in regulating nutrient supply and preventing neurotoxicity. Human in vitro models, such as microphysiological systems (MPS), are being developed to better understand neurodegenerative diseases. Recent advances in neurovascular barrier modeling using human cells have shown potential for modeling the inner blood-retinal barrier (iBRB) and can be leveraged in developing new iBRB models. Personalized cellular inputs and improved pre-clinical testing can be achieved through MPS-based strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Food Science & Technology
Aaron Alonso Torrens, Christopher A. Mitchell, L. Kirsty Pourshahidi, Brian Og Murphy, William Allwood, Lisa Rizzetto, Matthias Scholz, Kieran Tuohy, Gema Pereira-Caro, Jose Manuel Moreno-Rojas, Gordon McDougall, Chris I. R. Gill
Summary: Disruption of microvascular architecture is a common pathogenic mechanism in Alzheimer's disease progression. Long-term feeding of raspberries showed limited modulation of microbiota and no substantive effect on microvascular architecture or cognition in APP/PS-1 mouse model.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Review
Microbiology
Lauren E. Hudson, Sarah E. Anderson, Anita H. Corbett, Tracey J. Lamb
CLINICAL MICROBIOLOGY REVIEWS
(2017)
Review
Engineering, Biomedical
Caroline E. Hansen, Yongzhi Qiu, Owen J. T. McCarty, Wilbur A. Lam
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 20
(2018)
Article
Pharmacology & Pharmacy
Edward T. Morgan, Joseph L. Dempsey, Sylvie M. Mimche, Tracey J. Lamb, Supriya Kulkarni, Julia Yue Cui, Hyunyoung Jeong, Angela L. Slitt
DRUG METABOLISM AND DISPOSITION
(2018)
Article
Infectious Diseases
Leen Vandermosten, Thao-Thy Pham, Hendrik Possemiers, Sofie Knoops, Evelien Van Herck, Julie Deckers, Blandine Franke-Fayard, Tracey J. Lamb, Chris J. Janse, Ghislain Opdenakker, Philippe E. Van den Steen
Article
Infectious Diseases
Sylvie M. Mimche, Choon-myung Lee, Ken H. Liu, Patrice N. Mimche, R. Donald Harvey, Thomas J. Murphy, Beatrice A. Nyagode, Dean P. Jones, Tracey J. Lamb, Edward T. Morgan
Article
Microbiology
Arnulfo Tunon-Ortiz, Tracey J. Lamb
Review
Immunology
Thayer K. Darling, Tracey J. Lamb
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Microbiology
Chester J. Joyner, Cristiana F. A. Brito, Celia L. Saney, Regina Joice Cordy, Maren L. Smith, Stacey A. Lapp, Monica Cabrera-Mora, Shuya Kyu, Nicolas Lackman, Mustafa Nural, Jeremy D. DeBarry, Jessica C. Kissinger, Mark P. Styczynski, F. Eun-Hyung Lee, Tracey J. Lamb, Mary R. Galinski, Alberto Moreno, Dean P. Jones, Rabindra Tirouvanziam, Chris Ibegbu, Steven E. Bosinger, Hao Wu, Ignacio Sanz, Anapatricia Garcia, Amy K. Stout, Jianlin Jiang, Allison Hankus, Stephanie Soderberg, Juan B. Gutierrez, Jung-Ting Chien, Suman B. Pakala, Mustafa Nural, Jay Humphrey, Nicholas Lackman, Eberhard O. Voit, Luis L. Fonseca, Yan Tang, John W. Barnwell, Amy Kong, Douglas Nace, Gregory K. Tharp, Mariko S. Peterson, Esmeralda V. S. Meyer, Shuzhao Li, Dave C. Anderson, Jan Pohl
Article
Infectious Diseases
Mellina T. Srey, Alessia Taccogna, Yelena Oksov, Sara Lustigman, Pei-Yi Tai, John Acord, Murray E. Selkirk, Tracey J. Lamb, David B. Guiliano
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Review
Immunology
Adesola C. Olatunde, J. Scott Hale, Tracey J. Lamb
Summary: Tfh cells are crucial for providing help for B cells in germinal centers, contributing to effective and long-lasting humoral immune responses. The cytokine-skewed differentiation and functions of Tfh cells play a significant role in modulating disease progression and humoral immune responses.
TRENDS IN IMMUNOLOGY
(2021)
Article
Hematology
Marcus A. Carden, Meredith E. Fay, Xinran Lu, Robert G. Mannino, Yumiko Sakurai, Jordan C. Ciciliano, Caroline E. Hansen, Satheesh Chonat, Clinton H. Joiner, David K. Wood, Wilbur A. Lam
Article
Chemistry, Analytical
Caroline E. Hansen, Wilbur A. Lam
ANALYTICAL CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Caroline E. Hansen, David R. Myers, W. Hunter Baldwin, Yumiko Sakurai, Shannon L. Meeks, L. Andrew Lyon, Wilbur A. Lam