Review
Chemistry, Analytical
Adriana Feldner, Julia Voelkle, Peter Lieberzeit, Philipp Fruhmann
Summary: Molecularly imprinted polymers (MIPs) are useful receptor materials in chemical sensing with wide applications. Conductive molecularly imprinted polymers (cMIPs) have great potential in the ongoing digitalization due to their simplicity and easy connection to sensing platforms. This review provides an overview of the synthetic approaches and detection limits of cMIPs, and discusses their applications and challenges in sensing systems.
Article
Engineering, Multidisciplinary
Eduardo Jara-Cornejo, Sabir Khan, Jaime Vega-Chacon, Ademar Wong, Lariel Chagas da Silva Neres, Gino Picasso, Maria D. P. T. Sotomayor
Summary: This study focuses on developing biomimetic sensors inspired by biological systems for the detection of methotrexate contaminants in environmental samples. Methotrexate is widely used for cancer and autoimmune disease treatment, and its residues in the environment are considered emerging contaminants of great concern. The proposed sensor, constructed using polypyrrole-based molecularly imprinted polymer (MIP) electrodeposited on a glassy carbon electrode modified with multi-walled carbon nanotubes, showed a detection limit of 2.7 x 10(-9) mol L-1 for methotrexate and a linear range of 0.01-125 mu mol L-1. The sensor demonstrated high selectivity with only a 15.4% electrochemical signal decay when interferents were incorporated in the standard solution. Overall, the results suggest that the proposed sensor is highly promising and suitable for quantifying methotrexate in environmental samples.
Review
Polymer Science
Simonas Ramanavicius, Arunas Jagminas, Arunas Ramanavicius
Summary: This review outlines the important directions and applications of polymer-based semiconducting materials in affinity sensors, focusing on the bioanalytical application of conducting polymers such as polypyrrole and polyaniline. It also discusses advancements in polymerization techniques and analytical signal transduction methods applied in affinity sensors. Additionally, the review highlights the development and application of molecularly imprinted polymer-based structures as potential replacements for expensive affinity reagents.
Review
Chemistry, Analytical
Wang Li, Xiaoyue Zhang, Tingting Li, Yibing Ji, Ruijun Li
Summary: The integration of molecularly imprinted polymers with paper-based analytical devices (MIP-PADs) offers advanced analytical devices with enhanced selectivity and sensitivity, as well as reduced assay time and cost. This technology has wide applications in biomedical diagnostics, environmental analysis, and food safety monitoring.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Analytical
Mayank Garg, Nicole Pamme
Summary: This review focuses on the removal strategies of templates from molecularly imprinted polymers (MIPs) used in diagnostic biosensors. Chemical-based and electrochemical-based template extraction approaches are summarized and evaluated, providing guidance for researchers in the fields of analytical chemistry, diagnostics, and materials science for the design of MIP-based sensors.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Dounia Elfadil, Abderrahman Lamaoui, Flavio Della Pelle, Aziz Amine, Dario Compagnone
Summary: This paper critically reviews the recent progress in MIP-based electrochemical sensors for food safety, discussing the advantages of using MIPs to improve selectivity in detecting food contaminants. The article provides a brief introduction to MIPs and electrochemical sensors, followed by a discussion of the recent achievements and applications in this field.
Review
Polymer Science
Xiaoyue Zhao, Yong Wang, Pan Zhang, Zhemiao Lu, Yin Xiao
Summary: This review summarizes recent advances in the application of cyclodextrin-based molecular imprinting polymers (MIPs) in sample preparation, detection, sensing, and drug delivery over the past five years. It also discusses the specific roles of cyclodextrins in MIPs and elaborates on the challenges and future prospects in the application of cyclodextrins in MIPs.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Review
Polymer Science
Semra Akgonullu, Seckin Kilic, Cem Esen, Adil Denizli
Summary: The accurate detection of biological substances such as proteins has always been a hot topic in scientific research. Biomimetic sensors seek to imitate sensitive and selective mechanisms of biological systems and integrate these traits into applicable sensing platforms. Molecular imprinting technology has been extensively practiced in many domains, producing molecular recognition materials with specific capabilities. Molecularly imprinted polymers (MIPs), also known as plastic antibodies, are artificial receptors with high-affinity binding sites for a particular molecule or compound. MIPs for protein recognition are expected to have high affinity through interactions between polymer matrices and functional groups of the target protein. This critical review discusses recent advances in the synthesis, characterization, and application of MIP-based sensor platforms for protein detection.
Review
Polymer Science
Yunling Shao, Jiaqi Duan, Miao Wang, Jing Cao, Yongxin She, Zhen Cao, Guangyue Li, Fen Jin, Jing Wang, A. M. Abd El-Aty
Summary: Environmental chemical contaminants in food have a serious impact on human health and food safety. Molecularly imprinted polymers (MIPs) based on electrochemical biomimetic sensors offer a promising solution for detecting emerging chemical contaminants. The use of MIPs overcomes the limitations of conventional detection methods and enables efficient, sensitive, and cost-effective detection of contaminants.
Review
Chemistry, Analytical
Nadja Leibl, Karsten Haupt, Carlo Gonzato, Luminita Duma
Summary: The development of MIP-based chemosensors is driven by the need for simplicity and high selectivity in detecting various compounds in fields such as medical diagnosis, environmental monitoring, and explosive detection. Research efforts have been made to further develop this field, with a focus on discussing the pros and cons of MIP-based chemosensors.
Review
Chemistry, Analytical
Kshitij R. B. Singh, Arunadevi Natarajan
Summary: This review focuses on the formation mechanism of molecularly imprinted polymers (MIPs), the role of co-monomers and porogen, and the performance of optical sensors. The use of MIPs in microorganism detection and cancer diagnosis is also discussed, along with the challenges faced in their application.
Article
Chemistry, Analytical
Tiziano Di Giulio, Elisabetta Mazzotta, Cosimino Malitesta
Summary: In this study, electropolymerization of a scopoletin-based molecularly imprinted polymer for lysozyme detection was reported. Two different approaches were used for imprinting lysozyme, and the electrochemical responses of MIPs to Lyz were tested, showing good selectivity and competitive rebinding ability. The MIP prepared with enzyme immobilization exhibited higher imprinting factor and lower detection limit compared to the MIP prepared without enzyme immobilization.
Review
Chemistry, Physical
Simonas Ramanavicius, Arunas Ramanavicius
Summary: Achievements in polymer chemistry have enabled the design of artificial phase boundaries through the modification of selected molecules and larger structures. These structures have proven to be useful for the development of new materials suitable for affinity chromatography and sensors. This review provides an overview of the synthesis of molecularly imprinted polymers (MIPs) and their applicability in the design of affinity sensors. The use of conducting polymers, such as polypyrrole, polyaniline, and polythiophene, shows promising capabilities for molecular imprinting. The review also discusses methods for the synthesis of conducting polymer-based MIPs and the challenges and trends in MIP technology.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Analytical
Jose Luiz da Silva, Edervaldo Buffon, Maisa Azevedo Beluomini, Lauro Antonio Pradela-Filho, Diele Aparecida Gouveia Araujo, Andre Luiz Santos, Rgina Massako Takeuchi, Nelson Ramos Stradiotto
Summary: This study developed an innovative imprinted voltammetric sensor for sensitive detection of lactose, which showed high selectivity and sensitivity in detecting lactose content accurately under various conditions, and exhibited good stability and reproducibility.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Analytical
Simonas Ramanavicius, Inga Morkvenaite-Vilkonciene, Urte Samukaite-Bubniene, Vilma Ratautaite, Ieva Plikusiene, Roman Viter, Arunas Ramanavicius
Summary: This review focuses on the development of molecularly imprinted polymers (MIPs) and their application in sensor design. MIP-based conducting polymers, such as polypyrrole, are frequently used in sensor design due to their unique properties. The review also provides an overview of other materials that can be molecularly imprinted and discusses methods for designing MIP-based sensing structures and transducing analytical signals. Furthermore, it explores expected new trends and horizons in the application of MIP-based structures.
Article
Chemistry, Analytical
Aysu Yarman, Frieder W. Scheller
Article
Chemistry, Multidisciplinary
Aysu Yarman
TURKISH JOURNAL OF CHEMISTRY
(2018)
Article
Polymer Science
Goksu Ozcelikay, Sevinc Kurbanoglu, Xiaorong Zhang, Cagla Kosak Soz, Ulla Wollenberger, Sibel A. Ozkan, Aysu Yarman, Frieder W. Scheller
Review
Chemistry, Analytical
Aysu Yarman, Frieder W. Scheller
Article
Chemistry, Analytical
Goksu Ozcelikay, Sevinc Kurbanoglu, Aysu Yarman, Frieder W. Scheller, Sibel A. Ozkan
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Chemistry, Analytical
Aysu Yarman, Sevinc Kurbanoglu, Ingo Zebger, Frieder W. Scheller
Summary: A wide range of publications over the past decade have focused on Molecularly Imprinted Polymers (MIPs), with approximately 10% of these papers detailing their application in protein recognition. The straightforward synthesis of MIPs, using only a few functional monomers, allows for multi-analyte measurements and provides advantages over the complexity of proteins.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Electrochemistry
Giorgio Caserta, Xiaorong Zhang, Aysu Yarman, Eszter Supala, Ulla Wollenberger, Robert E. Gyurcsanyi, Ingo Zebger, Frieder W. Scheller
Summary: This study explores the preparation of peptide-imprinted polymer nanofilms for selective recognition of human adult hemoglobin, utilizing a hierarchical approach with superior affinity and providing key mechanistic insights towards the stability of the formed MIPs.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Xiaorong Zhang, Giorgio Caserta, Aysu Yarman, Eszter Supala, Armel F. Tadjoung Waffo, Ulla Wollenberger, Robert E. Gyurcsanyi, Ingo Zebger, Frieder W. Scheller
Summary: The study utilized epitope imprinting polymers to recognize parent proteins, revealing non-specific binding between target peptides and parent proteins, as well as stronger non-specific binding of HbA to MIPs than target peptides.
Article
Chemistry, Multidisciplinary
Zsofia Bognar, Eszter Supala, Aysu Yarman, Xiaorong Zhang, Frank F. Bier, Frieder W. Scheller, Robert E. Gyurcsanyi
Summary: This study presents a versatile approach for generating epitope-imprinted polymer-based microarrays for protein recognition on surface plasmon resonance imaging (SPRi) chips, which can rapidly screen binding kinetics of various targets, including the SARS-CoV-2 spike protein. The highly affine molecularly imprinted polymers (MIPs) developed in this study showed lower nanomolar dissociation constants for RBD, exceeding natural affinity levels and even binding SARS-CoV-2 virus particles with higher affinity.
Article
Chemistry, Multidisciplinary
Xiaorong Zhang, Armel T. Waffo, Aysu Yarman, Norbert Kovacs, Zsofia Bognar, Ulla Wollenberger, Ibrahim M. El-Sherbiny, Rabeay Y. A. Hassan, Frank F. Bier, Robert E. Gyurcsanyi, Ingo Zebger, Frieder W. Scheller
Summary: This study aims to gain a mechanistic understanding of the formation of epitope-imprinted polymer nanofilms. The affinity towards different peptides is mainly determined by a four-amino acid motif present in the template peptide. However, the parent proteins RBD and spike protein exhibit higher affinity on the nanofilm surface.
Review
Engineering, Multidisciplinary
Aysu Yarman, Sevinc Kurbanoglu
Summary: Since the outbreak of the COVID-19 pandemic, various methods for fast and accurate diagnosis of SARS-CoV-2 have been developed and utilized, including RT-PCR, immunoassays, CRISPR, RT-LAMP, and bio(mimetic) sensors. This article provides an overview of the applications of MIP-based sensors since the beginning of the pandemic.
Article
Pharmacology & Pharmacy
Sevinc Kurbanoglu, Aysu Yarman
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Review
Chemistry, Physical
Frieder W. Scheller, Xiaorong Zhang, Aysu Yarman, Ulla Wollenberger, Robert E. Gyurcsanyi
CURRENT OPINION IN ELECTROCHEMISTRY
(2019)
Review
Chemistry, Analytical
Aysu Yarman, Katharina J. Jetzschmann, Bettina Neumann, Xiaorong Zhang, Ulla Wollenberger, Aude Cordin, Karsten Haupt, Frieder W. Scheller
