Article
Environmental Sciences
Jinjun Ran, C. Mary Schooling, Lefei Han, Shengzhi Sun, Shi Zhao, Xiaohong Zhang, King-Pan Chan, Fang Guo, Ruby Siu-Yin Lee, Yulan Qiu, Linwei Tian
Summary: Long-term exposure to PM2.5 is positively associated with a higher risk of all-cause dementia incidence, with an estimated hazard ratio of 1.06 per every 3.8 μg/m(3) increase in annual mean PM2.5 exposure. No effect modifications by age, sex, BMI, hypertension, diabetes, or heart disease were found in this study.
ENVIRONMENTAL POLLUTION
(2021)
Review
Public, Environmental & Occupational Health
S. Cheng, Y. Jin, Y. Dou, Y. Zhao, Y. Duan, H. Pei, P. Lyu
Summary: This study analysed the association between particulate matter 2.5 (PM2.5) and dementia, including Alzheimer's disease (AD) and vascular dementia (VaD). The results showed that long-term exposure to PM2.5 may increase the risk of dementia, including AD and VaD. These findings emphasize the need for further research on the detrimental impact of PM2.5 and strategies to reduce air pollution.
Article
Environmental Sciences
Jung-Im Shim, Garam Byun, Jong-Tae T. Lee
Summary: This study investigated the association between long-term exposure to PM10 and the risk of developing Alzheimer's disease and vascular dementia in the elderly population. The results showed a significant link between long-term PM10 exposure and the risk of developing vascular dementia, but not Alzheimer's disease.
ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Teresa Urbano, Annalisa Chiari, Carlotta Malagoli, Andrea Cherubini, Roberta Bedin, Sofia Costanzini, Sergio Teggi, Giuseppe Maffeis, Marco Vinceti, Tommaso Filippini
Summary: Exposure to outdoor air pollutants, particularly PM10, may nonlinearly increase the risk of conversion from MCI to dementia. Higher PM10 levels were associated with increased concentrations of cerebrospinal fluid tau proteins and decreased beta-amyloid levels. The risk of dementia was positively associated with mean PM10 levels above 10 μg/m3 and maximum PM10 levels above 35 μg/m3.
ENVIRONMENTAL RESEARCH
(2023)
Review
Geriatrics & Gerontology
Wenjuan Guo, Jing Shi
Summary: There is a relationship between white matter hyperintensities (WMH) volume and cognitive decline in patients with cerebral small vessel disease (CSVD). WMH is associated with an increased risk of mild cognitive impairment (MCI) and dementia, with a higher risk observed in longer follow-up periods.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Kevin J. Sullivan, Xinhui Ran, Fan Wu, Chung-Chou H. Chang, Ravi Sharma, Erin Jacobsen, Sarah Berman, Beth E. Snitz, Akira Sekikawa, Evelyn O. Talbott, Mary Ganguli
Summary: This study examined the association between ambient PM2.5 levels and the risk of incident MCI and dementia in an older population, finding that higher estimated PM2.5 levels were associated with increased risk of both conditions, particularly with longer-term exposure.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Clinical Neurology
Ashwati Vipin, Dilip Kumar, See Ann Soo, Fatin Zahra Zailan, Yi Jin Leow, Chen Ling Koh, Adeline Su Lyn Ng, Kok Pin Ng, Nagaendran Kandiah
Summary: White matter hyperintensities, a marker of small-vessel cerebrovascular disease and APOE4 allele, have different effects on grey matter volume in individuals with and without APOE4, which has implications for clinical trials.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Environmental Sciences
Jinjun Ran, Yamin Zhang, Lefei Han, Shengzhi Sun, Shi Zhao, Chen Shen, Xiaohong Zhang, King-Pan Chan, Ruby Siu-yin Lee, Yulan Qiu, Linwei Tian
Summary: In the elderly population of Hong Kong, habitual physical activity and long-term exposure to PM2.5 were found to have opposite associations with incident dementia. Physical activity remains beneficial to individuals regardless of exposure to air pollution.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Geriatrics & Gerontology
Cynthia Felix, Caterina Rosano, Xiaonan Zhu, Jason D. Flatt, Andrea L. Rosso
Summary: This study found associations between social engagement and gray matter microstructure in older adults. By analyzing the relationship between social engagement and specific brain regions, researchers discovered that social engagement may help protect brain integrity. This association remained significant even after adjusting for gender differences.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2021)
Article
Neurosciences
Renee C. Groechel, Michael L. Alosco, Diane Dixon, Yorghos Tripodis, Jesse Mez, Lee Goldstein, Andrew E. Budson, Wei Qiao Qiu, Ronald J. Killiany
Summary: This study demonstrates the differences in white matter integrity in individuals across the dementia continuum and their associations with gray matter volume and cognitive function.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Neurosciences
Tosca O. E. de Crom, Bigina N. R. Ginos, Anna Oudin, M. Kamran Ikram, Trudy Voortman, M. Arfan Ikram
Summary: According to the Rotterdam Study, exposure to air pollution has been suggested to be associated with an increased risk of dementia. However, this study found no clear evidence for an association between exposure to air pollution and the risk of dementia or cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Environmental Sciences
Hedi Katre Kriit, Bertil Forsberg, Daniel Oudin Astrom, Anna Oudin
Summary: This study estimated that approximately 5% of annual dementia cases in Sweden could be attributed to PM2.5 exposure, leading to a substantial monetary burden. These findings highlight the importance of considering airborne toxic pollutants associated with dementia incidence in public health policy decisions.
ENVIRONMENTAL HEALTH
(2021)
Article
Neurosciences
Rachel M. Shaffer, Ge Li, Sara D. Adar, C. Dirk Keene, Caitlin S. Latimer, Paul K. Crane, Eric B. Larson, Joel D. Kaufman, Marco Carone, Lianne Sheppard
Summary: The association between PM2.5 and AD neuropathology in older adults is inconclusive, with some suggesting an increased risk of neuropathology while others suggesting a decreased risk. Further research is needed to confirm these findings and explore alternative mechanistic pathways for the disease.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Yair Mina, Tianxia Wu, Hsing-Chuan Hsieh, Dima A. Hammoud, Swati Shah, Chuen-Yen Lau, Lillian Ham, Joseph Snow, Elizabeth Horne, Anuradha Ganesan, Stanley I. Rapoport, Edmund C. Tramont, Daniel S. Reich, Brian K. Agan, Avindra Nath, Bryan R. Smith
Summary: The study found that HIV infection is associated with a higher incidence of brain white matter hyperintensities (WMH), primarily due to aging and modifiable comorbidities.
Article
Neurosciences
Dilip Kumar, Chathuri Yatawara, Brian Wang, Benjamin Wong, Yi Jayne Tan, Fatin Zahra Zailan, Kok Pin Ng, Nagaendran Kandiah
Summary: This study found that the APOE4 allele may aggravate the relationship between WMH and cognitive decline in prodromal dementia, especially in terms of memory. Furthermore, it was observed that APOE4 carriers with confluent WMH are more likely to have impaired episodic memory.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Jason G. Kilian, Heng-Wei Hsu, Kenneth Mata, Fred W. Wolf, Masashi Kitazawa
Article
Cell Biology
David Baglietto-Vargas, Gilberto Aleph Prieto, Agenor Limon, Stefania Forner, Carlos J. Rodriguez-Ortiz, Kenji Ikemura, Rahasson R. Ager, Rodrigo Medeiros, Laura Trujillo-Estrada, Alessandra C. Martini, Masashi Kitazawa, Jose C. Davila, Carl W. Cotman, Antonia Gutierrez, Frank M. LaFerla
Article
Neurosciences
Joannee Zumkehr, Carlos J. Rodriguez-Ortiz, Rodrigo Medeiros, Masashi Kitazawa
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Review
Toxicology
Heng-Wei Hsu, Stephen C. Bondy, Masashi Kitazawa
TOXICOLOGICAL SCIENCES
(2018)
Article
Neurosciences
Siok Lam Lim, Diana Nguyen Tran, Joannee Zumkehr, Christine Chen, Sagar Ghiaar, Zanett Kieu, Emmanuel Villanueva, Victoria Gallup, Carlos J. Rodriguez-Ortiz, Masashi Kitazawa
Review
Biochemistry & Molecular Biology
Tee Jong Huat, Judith Camats-Perna, Estella A. Newcombe, Nicholas Valmas, Masashi Kitazawa, Rodrigo Medeiros
JOURNAL OF MOLECULAR BIOLOGY
(2019)
Article
Toxicology
Heng-Wei Hsu, Carlos J. Rodriguez-Ortiz, Siok Lam Lim, Joannee Zumkehr, Jason G. Kilian, Janielle Vidal, Masashi Kitazawa
TOXICOLOGICAL SCIENCES
(2019)
Article
Multidisciplinary Sciences
Alessandra Cadete Martini, Angela Gomez-Arboledas, Stefania Forner, Carlos J. Rodriguez-Ortiz, Amanda McQuade, Emma Danhash, Jimmy Phan, Dominic Javonillo, Jordan-Vu Ha, Melanie Tram, Laura Trujillo-Estrada, Celia da Cunha, Rahasson R. Ager, Jose C. Davila, Masashi Kitazawa, Mathew Blurton-Jones, Antonia Gutierrez, David Baglietto-Vargas, Rodrigo Medeiros, Frank M. LaFerla
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Stefania Forner, Alessandra C. Martini, G. Aleph Prieto, Cindy T. Dang, Carlos J. Rodriguez-Ortiz, Jorge Mauricio Reyes-Ruiz, Laura Trujillo-Estrada, Celia da Cunha, Elizabeth J. Andrews, Jimmy Phan, Jordan Vu Ha, Allissa V. Z. D. Chang, Yona Levites, Pedro E. Cruz, Rahasson Ager, Rodrigo Medeiros, Masashi Kitazawa, Charles G. Glabe, Carl W. Cotman, Todd Golde, David Baglietto-Vargas, Frank M. LaFerla
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Carlos J. Rodriguez-Ortiz, Gilberto Aleph Prieto, Alessandra C. Martini, Stefania Forner, Laura Trujillo-Estrada, Frank M. LaFerla, David Baglietto-Vargas, Carl W. Cotman, Masashi Kitazawa
Article
Neurosciences
Siok Lam Lim, Diana Nguyen Tran, Zanett Kieu, Christine Chen, Emmanuel Villanueva, Sagar Ghiaar, Victoria Gallup, Joannee Zumkehr, David H. Cribbs, Carlos J. Rodriguez-Ortiz, Masashi Kitazawa
MOLECULAR NEUROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Siok Lam Lim, Carlos J. Rodriguez-Ortiz, Heng-Wei Hsu, Jie Wu, Joannee Zumkehr, Jason Kilian, Janielle Vidal, Pinar Ayata, Masashi Kitazawa
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2020)
Article
Neurosciences
Heng-Wei Hsu, Carlos J. Rodriguez-Ortiz, Joannee Zumkehr, Masashi Kitazawa
Summary: The study demonstrates that proinflammatory cytokine IL-1β suppresses LRP1 expression in MVECs through microRNAs and NF-κB, impacting Aβ clearance and potentially contributing to the development of Alzheimer's disease.
Correction
Multidisciplinary Sciences
Alessandra Cadete Martini, Angela Gomez-Arboledas, Stefania Forner, Carlos J. Rodriguez-Ortiz, Amanda McQuade, Emma Danhash, Jimmy Phan, Dominic Javonillo, Jordan-Vu Ha, Melanie Tram, Laura Trujillo-Estrada, Celia da Cunha, Rahasson R. Ager, Jose C. Davila, Masashi Kitazawa, Mathew Blurton-Jones, Antonia Gutierrez, David Baglietto-Vargas, Rodrigo Medeiros, Frank M. LaFerla
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)