Article
Gerontology
Kathy Black, Patricia Oh
Summary: The study found strong evidence of progress in areas such as leadership and governance, resources mobilization, application of the age-friendly framework, and multisector collaboration in American age-friendly communities. However, there were relatively weaker performances in older adult involvement, monitoring and reporting of evaluative findings, and overall summation and dissemination plans.
Editorial Material
Biochemistry & Molecular Biology
David Barneda, Len Stephens, Phillip Hawkins
Summary: Li et al. conducted a proximity-interaction screen in mammalian cells to study the effector proteins of 25 members of the Arf family of small GTPases. The study has provided an important resource for researchers in various areas of cell biology and revealed new cellular roles for some of the less studied members of this family, such as the regulation of PLD1 by ARL11/14 in phagocytosis and the regulation of PI4KB by ARL5A/5B in the Golgi.
Review
Medicine, General & Internal
Guenter K. Noe
Summary: The article describes current laparoscopic procedures for prolapse surgery and evaluates approaches in vaginal prolapse surgery, with a focus on the debate surrounding mesh use and potential implications for reconstructive laparoscopic surgery. The option of using autologous tissue in combination with laparoscopic techniques is discussed, alongside highlighting study data and problematic issues with existing techniques for future consideration.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Safa Shoaee, Hoang M. Luong, Jiage Song, Yingping Zou, Thuc-Quyen Nguyen, Dieter Neher
Summary: This review critically discusses the advancements in organic solar cells, specifically focusing on the PM6:Y6 material combination. The structural and physical properties of the combination are analyzed in relation to its photovoltaic performance. The review also addresses design principles, blend morphology, and degradation mechanisms, as well as unresolved issues in the field. Overall, the review provides a comprehensive understanding of the PM6:Y6 material combination and its potential for further development in organic solar cells.
ADVANCED MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Yifan Luo, Yidan Wang, Yue Ma, Puxiu Wang, Jian Zhong, Yang Chu
Summary: ARC is a phenomenon of increased renal function with sub-therapeutic drug concentrations and antibacterial exposure as main reasons for treatment failure in affected patients. Despite decades of research, there are still disputes and unresolved issues in this area. Future research should focus on clinical identification, metabolism, animal models, and treatment directions related to ARC.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Anita Fron, Alina Semianiuk, Uladzimir Lazuk, Kuba Ptaszkowski, Agnieszka Siennicka, Artur Leminski, Wojciech Krajewski, Tomasz Szydelko, Bartosz Malkiewicz
Summary: Our study provides an overview of the current state of artificial intelligence applications in urooncology and explores potential future advancements in this field. With remarkable progress already achieved, artificial intelligence has revolutionized urooncology by facilitating image analysis, grading, biomarker research, and treatment planning.
Review
Oncology
Laura Fejerman, Amelie G. Ramirez, Anna Maria Napoles, Scarlett Lin Gomez, Mariana C. Stern
Summary: The Hispanic/Latino(x) population in the United States is diverse and growing quickly. While cancer is the leading cause of death among this population, they have lower incidence rates of most common cancers compared to non-Hispanic White individuals. However, they have higher incidence rates of certain cancers, and tend to be diagnosed at later stages for certain types of cancer. Research on the etiology and outcomes of cancer in this population is lacking.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Oncology
Reyes Bernabe-Caro, Yuanbin Chen, Afshin Dowlati, Paula Eason
Summary: This study conducted a systematic literature review to evaluate the treatment landscape for patients with relapsed small-cell lung cancer. The results showed limited options for second-line treatment, and there are quality limitations in the studies of various drug classes. Currently, there is still a lack of satisfactory treatment strategies.
CLINICAL LUNG CANCER
(2023)
Article
Developmental Biology
Emma Siragher, Amanda N. Sferruzzi-Perri
Summary: Intrauterine hypoxia affects placental structure and function, impacting fetal growth. Research shows that hypoxia can lead to changes in placental structure, vascularization, and nutrient transport capacity. Additionally, certain genes and protein signaling pathways in the placenta play a key role in mediating hypoxia-induced alterations.
Article
Biochemistry & Molecular Biology
Nick Serpone
Summary: Sunscreens have been developed for decades to protect against the harmful effects of UV radiation, but questions remain as to whether they are effective in preventing sunburns, skin aging, and most importantly, skin cancers. Research in the past two decades has focused on protection against UVA radiation, with discussions also covering the safety of sunscreen ingredients and how to enhance their protective effects.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2021)
Review
Oncology
Jon Zugazagoitia, Luis Paz-Ares
Summary: Extensive-stage small-cell lung cancer is a challenging disease to treat, and despite improvements in first-line therapy, resistance remains a significant issue. Recent progress in understanding the molecular biology of SCLC holds potential for molecularly informed therapeutic strategies for patients with SCLC.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Yun Zheng, Tyler J. Slade, Lei Hu, Xian Yi Tan, Yubo Luo, Zhong-Zhen Luo, Jianwei Xu, Qingyu Yan, Mercouri G. Kanatzidis
Summary: This review summarizes the recent advances in defect engineering to enhance the thermoelectric performance and mechanical properties of inorganic materials, covering the classification and characterization of various defect types, as well as the effects of defect engineering on the properties of thermoelectric materials.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Kristina Krpina, Semir Vranic, Kresimir Tomic, Miroslav Samarzija, Lara Baticic
Summary: Small cell lung cancer (SCLC) is an aggressive malignancy with rapid proliferation, early dissemination, acquired therapy resistance, and poor prognosis. Early diagnosis, effective biomarkers, and advancements in therapeutic strategies are essential for improving survival rates and reducing the impact of this devastating disease. This review aims to comprehensively summarize current knowledge on diagnostic options, well-known and emerging biomarkers, and SCLC treatment strategies and discuss future perspectives on this aggressive malignancy.
Review
Oncology
Geou-Yarh Liou, Crystal J. Byrd
Summary: Among all types of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC) is the most common type and has an extremely low survival rate. Early detection is crucial to minimize the death toll. This review summarizes the current and potential liquid biomarkers for the diagnosis of PDAC.
Article
Biochemical Research Methods
David Sinton, Shana O. Kelley
Summary: The success of AbCellera Biologics Inc. can be attributed to their microfluidic antibody screening platform and service-based drug discovery business model. Their success motivations included common lab on a chip advantages, although there were also some non-critical factors.
