期刊
IMMUNE NETWORK
卷 18, 期 3, 页码 -出版社
KOREA ASSOC IMMUNOLOGISTS
DOI: 10.4110/in.2018.18.e22
关键词
Tobacco smoke pollution; Cigarette smoking; Mycobacterium tuberculosis; Latent tuberculous infection
类别
资金
- Potts Memorial Foundation
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development [1 I01 CX001452-01A1]
- National Institutes of Health [R21 AI121605-01]
Many studies have linked cigarette smoke (CS) exposure and tuberculosis (TB) infection and disease although much fewer have studied second-hand smoke (SHS) exposure. Our goal is to review the epidemiologic link between SHS and TB as well as to summarize the effects SHS and direct CS on various immune cells relevant for TB. PubMed searches were performed using the key words tuberculosis with cigarette, tobacco, or second-hand smoke. The bibliography of relevant papers were examined for additional relevant publications. Relatively few studies associate SHS exposure with TB infection and active disease. Both SHS and direct CS can alter various components of host immunity resulting in increased vulnerability to TB. While the epidemiologic link of these 2 health maladies is robust, more definitive, mechanistic studies are required to prove that SHS and direct CS actually cause increased susceptibility to TB.
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