Article
Multidisciplinary Sciences
Yuanyuan Fu, Dionyssios Katsaros, Nicoletta Biglia, Zhanwei Wang, Ian Pagano, Marcus Tius, Maarit Tiirikainen, Charles Rosser, Haining Yang, Herbert Yu
Summary: This study identified the important role of lncRNA TOPORS-AS1 in ovarian cancer, where high expression was associated with favorable survival outcomes. Experimental evidence suggests that TOPORS-AS1 may act as a tumor suppressor in ovarian cancer by disrupting the Wnt/beta-catenin signaling pathway. Furthermore, the upregulation of TOPORS-AS1 by VDR supports its potential as a prognostic marker and therapeutic target in ovarian cancer.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Fangfang Jian, Xiaoxia Che, Jingjing Zhang, Chang Liu, Gedan Liu, Yujing Tang, Weiwei Feng
Summary: Aberrant expression of lncRNA SOCS2-AS1 is found to be associated with endometrial cancer, where it acts as a tumor suppressor by binding to AURKA and promoting its degradation, leading to cell cycle arrest and apoptosis in EC cells. This suggests that SOCS2-AS1 may serve as a prognostic predictor and biomarker for AURKA-inhibitor treatment in EC patients.
CELL DEATH & DISEASE
(2021)
Review
Biotechnology & Applied Microbiology
Na He, Linbiao Xiang, Lei Chen, Haobin Tong, Keshen Wang, Jie Zhao, Feixue Song, Hanteng Yang, Xinyuan Wei, Zuoyi Jiao
Summary: This review highlights the clinical significance of FGD5-AS1 in human cancer and its role in tumorigenesis and tumor progression. It emphasizes the abnormal high expression of FGD5-AS1 in various cancers and its close correlation with tumor characteristics such as lymph node metastasis and tumor invasion. Additionally, the potential application of FGD5-AS1 as a diagnostic or prognostic biomarker is discussed.
Article
Medicine, General & Internal
Xiumiao Li, Junya Zhu, Yuling Zhong, Chang Liu, Mudi Yao, Yanan Sun, Wen Yao, Xisen Ni, Fen Zhou, Jin Yao, Qin Jiang
Summary: This study reveals that AQP4-AS1 plays a crucial role in retinal neurovascular dysfunction in diabetic retinopathy. Silencing AQP4-AS1 can alleviate retinal neurodegeneration and vascular dysfunction. AQP4-AS1 regulates retinal neurovascular dysfunction by affecting AQP4 levels.
Article
Multidisciplinary Sciences
Wenjuan Zha, Xiaomin Li, Xiaowei Tie, Yao Xing, Hao Li, Fei Gao, Ting Ye, Wangqi Du, Rui Chen, Yangchen Liu
Summary: The long noncoding RNA SBF2-AS1 is up-regulated in esophageal squamous cell carcinoma, and its expression is positively correlated with tumor size, but not with other factors. SBF2-AS1 can also affect the survival rate of ESCC.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Qingqing Zhu, Chongguo Zhang, Tianyu Qu, Xiyi Lu, Xuezhi He, Wei Li, Dandan Yin, Liang Han, Renhua Guo, Erbao Zhang
Summary: This study reveals that the lncRNA MNX1-AS1 upregulates c-Myc and E2F1 signaling by driving phase separation of IGF2BP1, leading to enhanced cell-cycle progression and proliferation in NSCLC.
Article
Multidisciplinary Sciences
Talia Guardia, Yuqi Zhang, Keyata N. Thompson, Se Jong Lee, Stuart S. Martin, Konstantinos Konstantopoulos, Aikaterini Kontrogianni-Konstantopoulos
Summary: Mounting evidence suggests that obscurin, a giant cytoskeletal protein, is involved in the predisposition and development of breast cancer. Low levels of obscurin correlate with reduced overall and relapse-free survival in breast cancer patients. The antisense lncRNA OBSCN-AS1 regulates obscurin expression and functions as a metastasis suppressor, potentially serving as prognostic biomarkers and therapeutic targets for metastatic breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Chen Zhong, Qian Yu, Yucong Peng, Shengjun Zhou, Zhendong Liu, Yong Deng, Leiguang Guo, Shiguang Zhao, Gao Chen
Summary: This study identified OXCT1-AS1 as a potential therapeutic target for glioma treatment, as high expression was associated with poor prognosis in GBM. OXCT1-AS1 inhibits glioma progression by acting as a ceRNA of miR-195 to enhance CDC25A expression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Jie Bin, Shaolin Nie, Ziyuan Tang, Anding Kang, Zhongping Fu, Yingbin Hu, Qianjin Liao, Wei Xiong, Yujuan Zhou, Yanyan Tang, Jiarui Jiang
Summary: The long noncoding RNA EPB41L4A-AS1 is highly expressed in colorectal cancer tissues and is associated with poor prognosis and tumor metastasis. It may be involved in the development of CRC by activating the Rho/Rho-associated protein kinase signaling pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Juanjuan Zhong, Jinlan Chen, Bei Wang, Zixian Zhou, Yujie Shen, Yibo Gong, Fangshun Tan, Chengfu Yuan
Summary: OIP5-AS1 is overexpressed in various tumors and plays a role in regulating tumor growth and progression in breast carcinoma, ovarian carcinoma, cervical carcinoma, lung carcinoma, laryngeal squamous cell gastric carcinoma, and hepatocellular carcinoma. Research evidence shows that OIP5-AS1 is involved in carcinoma proliferation, growth, migration, invasion, and apoptosis, indicating its potential as a biomarker or therapeutic target in multiple tumors.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Biotechnology & Applied Microbiology
Tao Cai, Binyu Peng, Jun Hu, Yan He
Summary: Gastric cancer is a significant health burden worldwide, but the molecular mechanisms underlying its progression are not well understood. This study reveals the role of BBOX1-AS1 in regulating gastric cancer progression through the miR-361-3p/MUC13 axis, providing a potential therapeutic target for the treatment of gastric cancer.
Article
Biotechnology & Applied Microbiology
Tianyi Ma, Tianyu Qiao, Ziming Yuan, Guiyu Wang, Rui Huang, Meng Wang, Hanqing Hu, Yihao Zhu, Xiaoming Zou, Xishan Wang
Summary: JAKMIP2-AS1 is significantly upregulated in colorectal cancer tissues, promoting cell proliferation and associated with poor prognosis. Inhibition of JAKMIP2-AS1 by RNAi decreases cell proliferation and hinders cell growth.
ONCOTARGETS AND THERAPY
(2021)
Article
Hematology
Xiaoxiao Ren, Huijuan Zhu, Keyong Deng, Xiaotong Ning, Lin Li, Dan Liu, Bin Yang, Chenyang Shen, Xianqiang Wang, Naqiong Wu, Shufeng Chen, Dongfeng Gu, Laiyuan Wang
Summary: This study demonstrates that TPRG1-AS1 inhibits migration of HASMCs by interacting with MYH9 protein, resulting in suppression of neointima formation and atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Dan-Dan Wang, Dong-Lei Sun, Shao-Peng Yang, Jia Song, Meng-Yao Wu, Wei-Wei Niu, Mei Song, Xiao-Lan Zhang
Summary: Recent studies have identified TNFRSF10A-AS1 as a highly expressed long noncoding RNA in colorectal cancer (CRC). It has been found that TNFRSF10A-AS1 promotes CRC tumorigenesis and progression by acting as a molecular sponge for miR-3121-3p and regulating HuR expression. These findings suggest that TNFRSF10A-AS1 could be a potential therapeutic target for CRC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell Biology
Gal Mazor, Dmitri Smirnov, Hila Ben David, Ekaterina Khrameeva, Debra Toiber, Barak Rotblat
Summary: The research discovered that the expression of TP73-AS1 is high in both natural and pathological aging brains, with YY1 identified as a key regulator of TP73-AS1. This study also revealed a new link between TMZ resistance and aging through the involvement of YY1 in TP73-AS1 regulation.
Review
Medicine, Research & Experimental
Li-Yun Fu, Shu-Wei Wang, Meng-Yuan Hu, Zhen-Luo Jiang, Li-Li Shen, Yu-Ping Zhou, Jun-Ming Guo, Yao-Ren Hu
Summary: Circular RNAs play a significant role in liver diseases, serving as potential diagnostic and prognostic markers with therapeutic translational value.
Article
Gastroenterology & Hepatology
Jianing Yan, Yongfu Shao, Haoxuan Lu, Qihua Ye, Guoliang Ye, Junming Guo
Summary: The study revealed that hsa_circ_0001020 is significantly upregulated in GC cell lines, tissue samples, and plasma, showing associations with distal metastasis and blood CA19-9. High hsa_circ_0001020 expression in GC patients correlated with decreased survival time, indicating its potential as an independent prognostic factor. The circRNA demonstrated superior screening potential as a biomarker for GC compared to traditional markers like CEA and CA19-9, and may provide insights into oncogenic pathways like the FoxO and p53 signaling pathways.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Cell & Tissue Engineering
Linwen Zhu, Zhe Li, Xiuchong Yu, Yao Ruan, Yijing Shen, Yongfu Shao, Xinjun Zhang, Guoliang Ye, Junming Guo
Summary: tRF-5026a is downregulated in gastric cancer patients and has a certain diagnostic value for predicting overall survival. It suppresses proliferation, migration, and cell cycle progression of gastric cancer cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Yibo Ma, Zhe Li, Dongnan Ma, Junming Guo, Weiliang Sun
Summary: The study found that hsa_circ_0003195 plays an important role in the diagnosis and prognosis of gastric cancer, and may be a new diagnostic and prognostic marker. The expression level of hsa_circ_0003195 is down-regulated in tissues and plasma from gastric cancer patients, and is correlated with differentiation, TNM stages, lymphatic metastasis, and distal metastasis.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medical Laboratory Technology
Yongfu Shao, Changlei Qi, Jianing Yan, Rongdan Lu, Guoliang Ye, Junming Guo
Summary: Hsa_circ_0086720 is found to be downregulated in gastric cancer and stably exists in plasma. As a biomarker for early gastric cancer screening, plasma Hsa_circ_0086720 has good sensitivity and specificity, and it can predict the prognosis of patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Genetics & Heredity
Qiuyan Weng, Yao Wang, Yaoyao Xie, Xiuchong Yu, Shuangshuang Zhang, Jiaxin Ge, Zhe Li, Guoliang Ye, Junming Guo
Summary: This review summarizes the biogenesis and classification of tRFs, discusses the biological functions of EV-associated tRFs, and explores their roles as potential biomarkers in human diseases.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Medicine, General & Internal
Qiuyan Weng, Zhe Li, Yaoyao Xie, Junming Guo, Yong Zhang, Guoliang Ye
Summary: This study analyzed the clinicopathological characteristics of long-term survivors with non-metastatic gastric signet ring cell carcinoma and identified independent predictors of long-term survival. Age, race, sex, marital status, tumor size, tumor infiltration, and lymph node involvement were found to be significant factors in predicting long-term survival.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Oncology
Zhe Li, Yi Xie, Bingxiu Xiao, Junming Guo
Summary: This study reveals that hsa_circ_0006282 is downregulated in gastric cancer and suppresses the growth of gastric cancer by regulating the PTEN/AKT signaling pathway.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiuchong Yu, Xuemei Song, Yaoyao Xie, Shuangshuang Zhang, Junming Guo
Summary: In this study, a quantitative method was established to detect plasma tRF-27 in gastric cancer patients. It was found that plasma tRF-27 levels were significantly increased and closely related to tumor size and Ki67 expression in gastric cancer patients. tRF-27 may serve as an independent predictor of overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medical Laboratory Technology
Chunli Cao, Yao Wang, Xinxin Wu, Zhe Li, Junming Guo, Weiliang Sun
Summary: This review describes the expression, function, and mechanism of circRNA-associated mTOR in various cancers. CircRNA-associated mTOR can regulate the progression and therapy of cancers through multiple signaling pathways.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Biochemistry & Molecular Biology
Yao Wang, Qiuyan Weng, Jiaxin Ge, Xinjun Zhang, Junming Guo, Guoliang Ye
Summary: tsRNAs, derived from tRNAs, play versatile roles in protein synthesis and fundamental biological processes. They regulate gene silencing, RNA stability, and translation, and are closely associated with cell proliferation, migration, cell cycle, and apoptosis. Abnormal expression of tsRNAs is linked to various human diseases, particularly cancer.
Article
Biochemistry & Molecular Biology
Ruan Yao, Guo Jun-Ming, Xiao Bing-Xiu
Summary: Circular RNAs are considered potential tumor biomarkers due to their unique structure and widespread presence in body fluids. Digital PCR technology, as the third generation PCR, enhances detection sensitivity without the need for a standard curve, thus improving detection accuracy, especially for low-expressed RNAs.
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Oncology
Xueping Tao, Yongfu Shao, Jianing Yan, Liyang Yang, Qihua Ye, Qingling Wang, Rongdan Lu, Junming Guo
Summary: Circular RNAs (circRNAs) are endogenous RNA molecules produced by alternative splicing, which play important roles in the proliferation, differentiation, invasion, and metastasis of cancer cells through various mechanisms. They are expected to provide novel perspectives for the diagnoses and treatments of gastrointestinal malignancies.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Oncology
Yijing Shen, Yaoyao Xie, Xiuchong Yu, Shuangshuang Zhang, Qiuyan Wen, Guoliang Ye, Junming Guo
Summary: The study identified a new tRF, tRF-19-3L7L73JD, with lower expression in gastric cancer patients, and its levels were found to be related to tumor size. Screening with tRF-19-3L7L73JD may serve as a diagnostic tool for gastric cancer. Furthermore, tRF-19-3L7L73JD demonstrated inhibitory effects on the growth of gastric cancer cells.
Article
Medicine, General & Internal
Yijing Shen, Xiuchong Yu, Yao Ruan, Zhe Li, Yaoyao Xie, Zhilong Yan, Junming Guo
Summary: This study identified a global tsRNA profile in plasma from gastric cancer patients, revealing 21 upregulated and 46 downregulated tsRNAs. Among them, tRF-33-P4R8YP9LON4VDP was found to inhibit proliferation of gastric cancer cells, suggesting its potential as a diagnostic biomarker and therapeutic target for gastric cancer.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
