☆ 4.2 Review

Dysregulated lipid storage and its relationship with insulin resistance and cardiovascular risk factors in non-obese Asian patients with type 2 diabetes

ADIPOCYTE (2018)

期刊

ADIPOCYTE

卷 7, 期 2, 页码 71-80

出版社

TAYLOR & FRANCIS INC

DOI: 10.1080/21623945.2018.1429784

关键词

type 2 diabetes; non-obese; subcutaneous fat; abdominal subcutaneous fat; visceral fat; intra-hepatic fat; intra-myocellular lipid; intra-pancreatic fat

类别

Endocrinology & Metabolism

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摘要

The prevalence of non-obese type 2 diabetes in Asians is up to 50%. This review aims to summarize the role of regional fat in the development of insulin resistance and cardiovascular risk in non-obese Asian type 2 diabetes as well as the role of intra-pancreatic fat and beta-cell dysfunction. The body fat content of non-obese Asian type 2 diabetic patients is not different from that of non-diabetic subjects but the proportion of intra-abdominal and intra-hepatic fat are greater. Visceral fat contributes to insulin resistance and cardiovascular risk in non-obese Asian type 2 diabetes. Intra-hepatic fat and the hypertrophic abdominal subcutaneous adipocytes are associated with insulin resistance and cardiovascular risk in non-obese, non-diabetic Asian subjects. It may be true in non-obese Asian type 2 diabetic patients. The role of intra-myocellular lipid and insulin resistance is uncertain. Intra-pancreatic fat may not be involved in beta-cell dysfunction in non-obese Asian type 2 diabetes.

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