期刊
FOOD AND ENERGY SECURITY
卷 7, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/fes3.126
关键词
asparagine metabolism; asparagine synthetase; glutamine synthetase; stress responses; systems approaches
资金
- Biotechnology and Biological Scientific Research Council (BBSRC) of the United Kingdom through stand-alone LINK project Genetic improvement of wheat to reduce the potential for acrylamide formation during processing [BB/I020918/1]
- BBSRC through the Designing Future Wheat Programme at Rothamsted Research
- BBSRC [BBS/E/C/00005202, BB/I020918/1, BBS/E/C/000I0250, BBS/E/C/000I0220] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/C/000I0250, BB/I020918/1, BBS/E/C/000I0220, BBS/E/C/00005202] Funding Source: researchfish
A detailed network describing asparagine metabolism in plants was constructed using published data from Arabidopsis (Arabidopsis thaliana) maize (Zea mays), wheat (Triticum aestivum), pea (Pisum sativum), soybean (Glycine max), lupin (Lupus albus), and other species, including animals. Asparagine synthesis and degradation is a major part of amino acid and nitrogen metabolism in plants. The complexity of its metabolism, including limiting and regulatory factors, was represented in a logical sequence in a pathway diagram built using yED graph editor software. The network was used with a Unique Network Identification Pipeline in the analysis of data from 18 publicly available transcriptomic data studies. This identified links between genes involved in asparagine metabolism in wheat roots under drought stress, wheat leaves under drought stress, and wheat leaves under conditions of sulfur and nitrogen deficiency. The network represents a powerful aid for interpreting the interactions not only between the genes in the pathway but also among enzymes, metabolites and smaller molecules. It provides a concise, clear understanding of the complexity of asparagine metabolism that could aid the interpretation of data relating to wider amino acid metabolism and other metabolic processes.
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