期刊
JOURNAL OF ADVANCED RESEARCH
卷 14, 期 -, 页码 63-71出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jare.2018.05.005
关键词
Fungal chitosan; Aloe vera extract; Tetracycline hydrochloride; Wound dressing
资金
- University Grants Commission (UGC), New Delhi, India under the UGC-BSR scheme
Chitosan composite material has been used as an efficient drug carrier for potential drug delivery systems in specific cases of wound dressing management. In the present study, 0.5 g/L of the antibiotic tetracycline hydrochloride (TCH) was loaded into 1% fungal chitosan (FCS) incorporated with 0.2% of Aloe vera extract (AVE). Two types of sponges were prepared, with and without AVE, such as FCS-AVE-TCH and FCS-TCH, respectively. They were characterized by UV-Visible spectrophotometer, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and scanning electron microscopy (SEM). A constant amount of cumulative TCH release was observed from FCS-AVE-TCH composite sponges at the phosphate buffer saline (pH 7.4), they exhibited good antibacterial activity against both Gram-positive and Gram-negative bacteria. Furthermore, the Vero cells (African green monkey kidney cell line) treated by the composites showed augmented cell viability, which suggests that it could be used as a cost-effective, potential wound dressing material. (C) 2018 Production and hosting by Elsevier B.V. on behalf of Cairo University.
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