Review
Cell Biology
Yanping Yue, Xinrong Lin, Xinyue Qiu, Lei Yang, Rui Wang
Summary: This paper summarizes the significant role of non-coding RNAs in gastric cancer, including regulating cell activities and influencing therapeutic resistance. In addition, the potential applications of ncRNAs in clinical trials and diagnosis of gastric cancer are discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Hassan Dastsooz, Ahad Alizadeh, Parham Habibzadeh, Ali Nariman, Asieh Hosseini, Yaser Mansoori, Hamed Haghi-Aminjan
Summary: Our study provides insights into the ceRNA networks of TCGA-GI cancers, revealing common and distinct mRNA and lncRNA with prognostic values. Furthermore, we identified several genes, including KDELC1, that could act as novel proto-oncogenes in cancers and serve as potential prognostic and therapeutic targets. Additionally, we found cell cycle and extracellular matrix structural constituent as the top shared KEGG and molecular function, respectively, among GI cancers.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Yasmine K. Abd El Fattah, Ahmed I. Abulsoud, Sherihan G. AbdelHamid, Nadia M. Hamdy
Summary: The lncRNA CCDC144NL-AS1 is functionally linked to several human cancers and could serve as a promising prognostic biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Cell Biology
Tao Su, Jiandong Liu, Nasha Zhang, Teng Wang, Linyu Han, Suzhen Wang, Ming Yang
Summary: N-6-Methyladenosine (m(6)A) methylation is a widely studied RNA modification that impacts cancer development by affecting RNA metabolism. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play important roles in various biological processes by regulating gene expression. Accumulated evidence suggests that m(6)A is involved in regulating the functions of lncRNAs and miRNAs through different mechanisms. Targeting m(6)A-related lncRNAs and miRNAs could provide novel treatment options for gastrointestinal cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Genetics & Heredity
Zihan Wang, Jintao Zhang, Tao Feng, Dong Zhang, Yun Pan, Xiaofei Liu, Jiawei Xu, Xinrui Qiao, Wenjing Cui, Liang Dong
Summary: This study established an lncRNA-mediated ceRNA regulatory network for studying T2 asthma, which may elucidate the pathogenesis and help find potential therapeutic targets. PCAT19 may serve as a potential immune-related biomarker for asthma and other respiratory diseases correlated with eosinophilic inflammation.
FRONTIERS IN GENETICS
(2022)
Review
Pathology
Esmat Abdi, Saeid Latifi-Navid, Hamid Latifi-Navid, Reza Safaralizadeh
Summary: Upper gastrointestinal cancers, such as oral, esophageal, and gastric cancers, have high mortality rates and are often diagnosed at advanced stages. Long non-coding RNAs play crucial roles in the development of these cancers and may serve as potential targets for targeted therapy. Genetic variations associated with lncRNAs could have predictive value for cancer risk and treatment outcomes.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Cell Biology
Junling Zhang, Xiaocong Pang, Lili Lei, Jixin Zhang, Xiaoqian Zhang, Ziyi Chen, Jing Zhu, Yong Jiang, Guowei Chen, Yingchao Wu, Tao Wu, Yisheng Pan, Yucun Liu, Yimin Cui, Xin Wang
Summary: CRART16 is highly expressed in gastric cancer tissues and correlates with advanced tumor stages and poor prognosis. It promotes angiogenesis in gastric cancer by downregulating miR-122-5p, upregulating FOS, and increasing VEGFD expression.
Review
Oncology
Junhui Hou, Gong Zhang, Xia Wang, Yuan Wang, Kefeng Wang
Summary: Chemotherapy is a crucial treatment for cancer, but the emergence of resistance poses a major challenge. Recent studies have identified a link between long non-coding RNA MALAT1 and chemotherapy resistance, suggesting its potential as a target for overcoming resistance. This review explores the mechanisms underlying MALAT1-mediated resistance and presents new possibilities for cancer treatment.
BIOMARKER RESEARCH
(2023)
Article
Cell Biology
Wei Hu, Yanru Wang, Zhixiao Fang, Wei He, Shengli Li
Summary: Through integrated analysis, we found the importance of lncRNA-immune interactions in prostate cancer, especially the impact of the TGF-beta signaling pathway and the key role of lncRNAs in regulating immune response. We also identified LINC00861 as a potential target for immunotherapy in prostate cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Jie Xu, Xia Wang, Chunming Zhu, Kefeng Wang
Summary: This review discusses the molecular mechanisms of MEG3 in different tumors and future challenges for the diagnosis and treatment of cancers through MEG3.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Bei Wang, Wen Xu, Chengyu Hu, Kai Liu, Jinlan Chen, Chong Guo, Chengfu Yuan
Summary: This review analyzes the role of lncRNA CASC11 in tumors, confirms its value as a therapeutic target, and highlights its relevance to tumor biological processes and clinical prognosis.
Review
Medicine, Research & Experimental
Chen Xue, Ganglei Li, Juan Lu, Jia Luo, Junjun Jia
Summary: MAGI2-AS3, a long non-coding RNA, is aberrantly expressed in solid tumors and has been shown to be correlated with patient clinical characteristics. It regulates multiple biological processes through target-gene regulation, making it a potential diagnostic biomarker and therapeutic target against solid tumors. Understanding the properties of MAGI2-AS3 may provide new insights into the diagnoses and treatments of solid tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Veterinary Sciences
Kazuhiko Imakawa, Yuta Matsuno, Hiroshi Fujiwara
Summary: This passage introduces the sine qua non of new life as fertilization and highlights the failure rates of fertilized eggs/blastocysts in cattle and human assisted reproductive procedures. It discusses the physiological events involved in the implantation of blastocysts to the maternal endometrium and the importance of EVs with miRNAs and lncRNAs in establishing the proper uterine environment.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Genetics & Heredity
Tingwei Liu, Jiacheng Shen, Qizhi He, Shaohua Xu
Summary: This study investigates the role of cisplatin resistance-related long non-coding RNAs (lncRNAs) in mediating the immune microenvironment in ovarian cancer. The novel lncRNA CTD-2288O8.1 was identified as a key gene in forming cisplatin resistance and affecting immunotherapy response. Furthermore, CTD-2288O8.1 was found to impact the signaling pathway activity in ovarian cancer cells and promote M2 polarization of macrophages.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Aiqing Zhao, Wanlin Liu, Xiaolong Cui, Na Wang, Yuxin Wang, Liang Sun, Huiqin Xue, Lishuan Wu, Shuxia Cui, Yun Yang, Rui Bai
Summary: TUSC7 is downregulated in osteosarcoma tissues and cell lines, and its overexpression inhibits cell proliferation, migration, and invasion while promoting apoptosis. TUSC7 exerts its role in OS cells by sponging miR-181a, thereby mediating its tumor suppressor function through the miR-181a/RASSF6 axis, potentially representing a new therapeutic target for osteosarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Genetics & Heredity
Gloria Ravegnini, Cesar Serrano, Riccardo Ricci, Qianqian Zhang, Irene Terrenato, Agnese Graziosi, Giorgia Valori, Stefania Landolfi, Patrizia Hrelia, Sabrina Angelini
Summary: This study found that miRNA expression in metastatic gastrointestinal stromal tumors has similar characteristics in primary sites and metastases, with the primary origin appearing to be the main determinant of the metastatic miRNA profile.
Article
Oncology
Antonio De Leo, Dario de Biase, Jacopo Lenzi, Giovanna Barbero, Daniela Turchetti, Marco Grillini, Gloria Ravegnini, Sabrina Angelini, Claudio Zamagni, Sara Coluccelli, Giulia Dondi, Pierandrea De Iaco, Anna Myriam Perrone, Giovanni Tallini, Donatella Santini, Claudio Ceccarelli
Summary: The study investigates the impact of ARID1A and CTNNB1/beta-catenin alterations in 125 molecularly classified endometrial carcinomas, showing that ARID1A mutation in NSMP cases is associated with worse outcomes while tumors with ARID1A wild-type and beta-catenin alteration have indolent clinicopathologic features. This study highlights how identifying these alterations in endometrial cancer can help characterize tumor aggressiveness and metastatic potential.
Review
Medicine, General & Internal
Matthew J. Page, Joanne E. McKenzie, Patrick M. Bossuyt, Isabelle Boutron, Tammy C. Hoffmann, Cynthia D. Mulrow, Larissa Shamseer, Jennifer M. Tetzlaff, Elie A. Akl, Sue E. Brennan, Roger Chou, Julie Glanville, Jeremy M. Grimshaw, Asbjorn Hrobjartsson, Manoj M. Lalu, Tianjing Li, Elizabeth W. Loder, Evan Mayo-Wilson, Steve McDonald, Luke A. McGuinness, Lesley A. Stewart, James Thomas, Andrea C. Tricco, Vivian A. Welch, Penny Whiting, David Moher
Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Matthew J. Page, Joanne E. McKenzie, Patrick M. Bossuyt, Isabelle Boutron, Tammy C. Hoffmann, Cynthia D. Mulrow, Larissa Shamseer, Jennifer M. Tetzlaff, Elie A. Akl, Sue E. Brennan, Roger Chou, Julie Glanville, Jeremy M. Grimshaw, Asbjorn Hrobjartsson, Manoj M. Lalu, Tianjing Li, Elizabeth W. Loder, Evan Mayo-Wilson, Steve McDonald, Luke A. McGuinness, Lesley A. Stewart, James Thomas, Andrea C. Tricco, Vivian A. Welch, Penny Whiting, David Moher
Summary: The article introduces PRISMA 2020, an updated reporting guideline for systematic reviews and meta-analyses.
Review
Oncology
Gloria Ravegnini, Francesca Gorini, Eugenia De Crescenzo, Antonio De Leo, Dario De Biase, Marco Di Stanislao, Patrizia Hrelia, Sabrina Angelini, Pierandrea De Iaco, Anna Myriam Perrone
Summary: Endometrial cancer is the most common gynecological cancer with challenging diagnostic and prognostic features. miRNAs play an important role in EC but there is currently lack of consensus in studies. Future research needs to explore more diagnostic and prognostic biomarkers and address the challenges in the current classification schemes.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Giulia Dondi, Eleonora Porcu, Alessandra De Palma, Giuseppe Damiano, Eugenia De Crescenzo, Linda Cipriani, Maria Dirodi, Gloria Ravegnini, Antonio De Leo, Margherita Nannini, Martina Ferioli, Alessio G. Morganti, Maria Abbondanza Pantaleo, Pierandrea De Iaco, Anna Myriam Perrone
Summary: Uterine sarcomas, rare cancers sometimes diagnosed in women of childbearing age, may be treated using fertility-sparing treatments in selected early stage cases. The outcomes of such treatments are influenced by the histology of the tumor, with leiomyosarcoma showing the worst prognosis and highest death rate among the subtypes mentioned in the systematic review.
Article
Oncology
Gloria Ravegnini, Antonio De Leo, Camelia Coada, Francesca Gorini, Dario de Biase, Claudio Ceccarelli, Giulia Dondi, Marco Tesei, Eugenia De Crescenzo, Donatella Santini, Angelo Gianluca Corradini, Giovanni Tallini, Patrizia Hrelia, Pierandrea De Iaco, Sabrina Angelini, Anna Myriam Perrone
Summary: The study found that miR-499a-3p and miR-499a-5p were overexpressed in CTNNB1 mutant EC patients, while NSMP patients with low miR-499a-5p expression had longer overall survival. Combining CTNNB1 status and miR-499a-5p levels allows better stratification of NSMP patients and may promote personalized treatment in intermediate-risk patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Maria A. Pantaleo, Milena Urbini, Angela Schipani, Margherita Nannini, Valentina Indio, Antonio De Leo, Bruno Vincenzi, Antonella Brunello, Giovanni Grignani, Mariaelena Casagrande, Elena Fumagalli, Elena Conca, Maristella Saponara, Elisa Gruppioni, Annalisa Altimari, Dario De Biase, Giovanni Tallini, Gloria Ravegnini, Daniela Turchetti, Marco Seri, Andrea Ardizzoni, Paola Secchiero, Annalisa Astolfi
Summary: Germline SDHA variants are highly prevalent in SDHA-deficient GIST, and the disease may occur in older adults as well. Genetic testing and surveillance should be conducted for SDHA mutation carriers and their relatives.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Camelia Alexandra Coada, Giulia Dondi, Gloria Ravegnini, Antonio De Leo, Donatella Santini, Eugenia De Crescenzo, Marco Tesei, Alessandro Bovicelli, Susanna Giunchi, Ada Dormi, Marco Di Stanislao, Alessio G. Morganti, Dario De Biase, Pierandrea De Iaco, Anna Myriam Perrone
Summary: Endometrial cancer is the most common gynecological malignancy. Risk stratification should be based on the integration of histologic, clinical, and molecular parameters.
Review
Biochemistry & Molecular Biology
Gloria Ravegnini, Pierandrea De Iaco, Francesca Gorini, Giulia Dondi, Isabella Klooster, Eugenia De Crescenzo, Alessandro Bovicelli, Patrizia Hrelia, Anna Myriam Perrone, Sabrina Angelini
Summary: Epithelial ovarian cancer is highly lethal due to nonspecific symptoms and lack of screening tests, leading to delayed diagnosis and treatment. The current clinical biomarker CA-125 is not sensitive or specific enough to monitor chemotherapy response or predict relapse risk. Thus, identifying circulating miRNAs associated with therapeutic treatments is crucial for personalized patient management.
Review
Health Care Sciences & Services
Gloria Ravegnini, Martina Ferioli, Alessio Giuseppe Morganti, Lidia Strigari, Maria Abbondanza Pantaleo, Margherita Nannini, Antonio De Leo, Eugenia De Crescenzo, Manuela Coe, Alessandra De Palma, Pierandrea De Iaco, Stefania Rizzo, Anna Myriam Perrone
Summary: The contribution of radiomics and AI in the radiological preoperative assessment of patients with uterine sarcomas (USs) is still insufficiently supported by evidence. While promising, the quality of studies should be a top priority in the utilization of these new technologies.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Gloria Ravegnini, Margherita Nannini, Valentina Indio, Cesar Serrano, Francesca Gorini, Annalisa Astolfi, Aldo Di Vito, Fabiana Morroni, Maria Abbondanza Pantaleo, Patrizia Hrelia, Sabrina Angelini
Summary: GISTs with PDGFRA D842V mutation show differential miRNA expression compared to non-D842V mutated GISTs. Differentially expressed miRNAs mainly target genes involved in the immune response pathways. Additionally, the miRNA-mRNA network reveals the indolent behavior of D842V mutated GISTs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Martina Ruscelli, Thais Maloberti, Angelo Gianluca Corradini, Francesca Rosini, Giulia Querzoli, Marco Grillini, Annalisa Altimari, Elisa Gruppioni, Viviana Sanza, Alessia Costantino, Riccardo Ciudino, Matteo Errani, Alessia Papapietro, Sara Coluccelli, Daniela Turchetti, Martina Ferioli, Susanna Giunchi, Giulia Dondi, Marco Tesei, Gloria Ravegnini, Francesca Abbati, Daniela Rubino, Claudio Zamagni, Emanuela D'Angelo, Pierandrea De Iaco, Donatella Santini, Claudio Ceccarelli, Anna Myriam Perrone, Giovanni Tallini, Dario de Biase, Antonio De Leo
Summary: This study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice of endometrial carcinoma (EC). It found that molecular classes and risk groups were correlated with disease-free survival. The study supports the prognostic importance of EC molecular classification and the essential role of histopathologic assessment in patients' management.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Camelia Alexandra Coada, Miriam Santoro, Vladislav Zybin, Marco Di Stanislao, Giulia Paolani, Cecilia Modolon, Stella Di Costanzo, Lucia Genovesi, Marco Tesei, Antonio De Leo, Gloria Ravegnini, Dario De Biase, Alessio Giuseppe Morganti, Luigi Lovato, Pierandrea De Iaco, Lidia Strigari, Anna Myriam Perrone
Summary: This study investigated the potential of radiomic features extracted from pre-surgical CT scans to predict disease-free survival (DFS) in endometrial cancer (EC) patients. Machine learning models achieved high sensitivities and specificities in both training and test sets, showing promise for predicting EC recurrence.
Review
Oncology
Federica Medici, Stefania Rizzo, Milly Buwenge, Alessandra Arcelli, Martina Ferioli, Gabriella Macchia, Francesco Deodato, Savino Cilla, Pierandrea De Iaco, Anna Myriam Perrone, Silvia Strolin, Lidia Strigari, Gloria Ravegnini, Alberto Bazzocchi, Alessio G. Morganti
Summary: Sarcopenia is a syndrome characterized by age-related loss of skeletal muscle mass and function, worsens radiation-induced toxicity and prognosis, and has a negative impact on the quality of life. Myosteatosis, a pathological infiltration of muscle tissue by adipose tissue, is correlated with prognosis in cancer patients. Sarcopenic obesity, characterized by large fat mass, is independently associated with higher mortality and worse complications compared to sarcopenia alone. Assessment of sarcopenia is commonly done using CT images. Several studies have shown the negative impact of sarcopenia on overall survival in patients undergoing radiation therapy for various tumors. Further research is needed to find ways to prevent and manage sarcopenia during and after radiation therapy in both adult and pediatric patients.
