Article
Biochemistry & Molecular Biology
Zhao Ju, Jianlin Shao, Meiling Zhou, Jing Jin, Huiji Pan, Ping Ding, Ruixue Huang
Summary: The study investigated the interaction between silica-induced epithelial-mesenchymal transition (EMT) related transcripts and cellular metabolism regulated by p53. Five significant p53-dependent metabolic pathways were identified, with benzeneacetic acid found to attenuate silica-induced EMT in a p53-dependent manner. However, despite extensive research, the clinical translation of p53-related studies remains limited.
CELL AND BIOSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Zhi Xiong Chong, Swee Keong Yeap, Wan Yong Ho
Summary: Osteosarcoma, a prevalent primary bone tumor, has high metastatic potential and poor prognosis. MiRNAs play crucial roles in regulating the EMT process in osteosarcoma, which may offer insights for prognostic and therapeutic strategies.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Environmental Sciences
Ruixue Huang, Chenjun Bai, Xiaodan Liu, Yao Zhou, Sai Hu, Decheng Li, Jing Xiang, Jihua Chen, Pingkun Zhou
Summary: This study identified a feedback loop involving p53, RMRP, miR122, and the Notch pathway that promotes EMT progression in silica-induced lung fibrosis. The upregulation of p53 upon silica exposure activates RMRP, which in turn decreases miR122 levels and activates the Notch signaling pathway. These findings provide new insights into the complex network regulating lung fibrosis.
Article
Environmental Sciences
Yunxia Wang, Yijue Zhong, Kunyan Sun, Yong Fan, Jiping Liao, Guangfa Wang
Summary: Chronic exposure to PM2.5 induces bronchial epithelial cell atypical hyperplasia and EMT event in vivo, and leads to expression differences of exosome-miRNAs in vitro. The identified exosome-miRNAs may partially contribute to lung cancer tumorigenesis induced by chronic PM2.5 exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Oncology
Vivek Kumar, Sameer Gupta, Amrita Chaurasia, Manisha Sachan
Summary: Epithelial ovarian cancer (EOC) is a lethal gynecological malignancy, and early diagnosis is crucial for management. Aberrantly expressed miRNAs, particularly miR-205, miR-200c, and miR-141, show potential as minimally invasive biomarkers for early detection of EOC. The miRNA panel has high diagnostic potential with elevated AUC, sensitivity, and specificity, especially in early-stage serum samples.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Juan Du, Wenjing Su, Xiaoguang Li, Tingjian Zu, Jinbo Bai, Weidong Zhang, Wei Zhou
Summary: In this study, the function of the long non-coding RNA LINC00525 in the progression of oral squamous cell carcinoma (OSCC) was investigated through in vitro and in vivo experiments. The results showed that LINC00525 was associated with OSCC survival and prognosis. Knockdown of LINC00525 decreased cell viability, migration and invasion properties, and increased apoptosis in OSCC cells. In vivo experiments also demonstrated that downregulation of LINC00525 reduced OSCC tumour growth. Therefore, LINC00525 may serve as a potential target for the treatment of OSCC.
Article
Oncology
Namhee Kim, Chae Young Hwang, Taeyoung Kim, Hyunjin Kim, Kwang-Hyun Cho
Summary: The process of epithelial-to-mesenchymal transition (EMT) in cancer cells, which contributes to metastasis and drug resistance, can be reversed through a systems biology approach. By targeting a core-regulatory circuit involving SMAD4 and ERK signaling inhibition, along with p53 activation, complete EMT reversal (rEMT) can be achieved without hybrid EMT properties. This reprogramming strategy restores chemosensitivity, offering potential therapeutic targets to eradicate metastatic potential by subverting EMT while avoiding hybrid states.
Article
Multidisciplinary Sciences
Guidantonio Malagoli Tagliazucchi, Anna J. Wiecek, Eloise Withnell, Maria Secrier
Summary: The authors develop a method to evaluate EMT transformation and trajectories in cancer transcriptomics data, characterising EMT macro-states, including a hybrid state, and EMT hallmarks. The study explores the spatial heterogeneity of EMT transformation and its interaction patterns with cytotoxic, NK cells and fibroblasts in the tumor microenvironment. It also provides a catalogue of genomic events underlying distinct evolutionary constraints on EMT transformation.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Salman Ul Islam, Muhammad Bilal Ahmed, Jong-Kyung Sonn, Eun-Jung Jin, Young-Sup Lee
Summary: PRP4 promotes pre-mRNA splicing and signal transduction. It induces drug resistance and EMT by binding to p53 and activating miR-210 and HIF-1α. Inhibition of PRP4 could benefit patients with colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
SunilGowda Sunnaghatta Nagaraja, Umadevi Subramanian, Devipriya Nagarajan
Summary: This study investigated the role of histone methyltransferase G9a in radiation-induced EMT signaling, finding that G9a inhibitor can inhibit radiation-induced EMT and ROS generation, as well as affect the expression of the E-cadherin promoter.
TOXICOLOGY IN VITRO
(2021)
Article
Clinical Neurology
Gang Zhu, Shirong Yang, Ronglin Wang, Jie Lei, Peigang Ji, Jiancai Wang, Kai Tao, Chen Yang, Shunnan Ge, Liang Wang
Summary: miR-154 acts as a biomarker in GBM by inhibiting migration, invasion, and EMT of GBM cells through targeting TCF12, suggesting the potential therapeutic target for GBM lies in the p53/miR-154/TCF12 pathway.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Review
Biochemistry & Molecular Biology
Oleg Semenov, Alexandra Daks, Olga Fedorova, Oleg Shuvalov, Nickolai A. Barlev
Summary: The aberrantly activated EMT program plays a central role in defining the critical features of aggressive carcinomas, and the p53 gene is critical for suppressing these features. Specific mutations in the p53 gene can convert it into an oncogene. This review contrasts the different regulatory roles of wild-type and mutant p53 in the process of EMT.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Chemistry, Analytical
Judit Bovari-Biri, Kitti Garai, Krisztina Banfai, Veronika Csongei, Judit E. Pongracz
Summary: The human body has multiple barriers to protect it from harm and maintain its integrity. These barriers include the skin, intestinal and respiratory epithelia, blood-brain barrier, and immune system. This review focuses on the physical barriers formed by cell layers and emphasizes the role of microRNA in maintaining the integrity of these barriers. Detecting changes in microRNA patterns has become important in diagnostics, prognosis, and therapy-response markers. The review also highlights the challenges in using liquid biopsies for assessing barrier integrity and differential microRNA detection.
Article
Oncology
Xu Zhou, Yu Zhou, Weiqing Shao, Liang Hong, Ming Lu, Wenwei Zhu
Summary: Acetyl-CoA metabolic aberration is associated with ICC metastasis, and down-regulation of ACOT12 promotes ICC metastasis, suggesting ACOT12 as a prognostic marker and potential therapeutic target for ICC metastasis.
Review
Oncology
Cexun Hu, Keyu Zhang, Feng Jiang, Hui Wang, Qixiang Shao
Summary: The thymus degenerates as humans age, leading to decreased immune response and higher susceptibility to autoimmune diseases. Epigenetics play a crucial role in regulating the development and senescence of thymic epithelial cells, offering potential therapeutic strategies for thymus atrophy.
CLINICAL EPIGENETICS
(2021)
Article
Cell Biology
Yutaro Otsuka, Hiroki Sato, Tsukasa Oikawa, Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Kiyoshi Fukunaga, Kanako C. Hatanaka, Yutaka Hatanaka, Yoshihiro Matsuno, Satoshi Fukuda, Hisataka Sabe
CELL COMMUNICATION AND SIGNALING
(2016)
Article
Cell Biology
Ari Hashimoto, Tsukasa Oikawa, Shigeru Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa, Yutaro Otsuka, Haruka Handa, Yasuhito Onodera, Jin-Min Nam, Chitose Oneyama, Masato Okada, Mitsunori Fukuda, Hisataka Sabe
JOURNAL OF CELL BIOLOGY
(2016)
Article
Multidisciplinary Sciences
Shigeru Hashimoto, Shuji Mikami, Hirokazu Sugino, Ayumu Yoshikawa, Ari Hashimoto, Yasuhito Onodera, Shotaro Furukawa, Haruka Handa, Tsukasa Oikawa, Yasunori Okada, Mototsugu Oya, Hisataka Sabe
NATURE COMMUNICATIONS
(2016)
Article
Oncology
A. Hashimoto, S. Hashimoto, H. Sugino, A. Yoshikawa, Y. Onodera, H. Handa, T. Oikawa, H. Sabe
Article
Cell Biology
Yutaro Otsuka, Tsukasa Oikawa, Hinako Yoshino, Shigeru Hashimoto, Haruka Handa, Hiroki Yamamoto, Ari Hashimoto, Hisataka Sabe
CELL COMMUNICATION AND SIGNALING
(2018)
Article
Multidisciplinary Sciences
Tsukasa Oikawa, Yutaro Otsuka, Yasuhito Onodera, Mei Horikawa, Haruka Handa, Shigeru Hashimoto, Yutaka Suzuki, Hisataka Sabe
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Tsukasa Oikawa, Atsuko Nakamura, Nobuyuki Onishi, Taketo Yamada, Koichi Matsuo, Hideyuki Saya
Article
Multidisciplinary Sciences
Tsukasa Oikawa, Hitomi Okamura, Franziska Dietrich, Yosuke Senju, Tadaomi Takenawa, Shiro Suetsugu
Article
Multidisciplinary Sciences
Maiko Matsushita, Yoshie Ozaki, Yuka Hasegawa, Fukiko Terada, Noriko Tabata, Hirokazu Shiheido, Hiroshi Yanagawa, Tsukasa Oikawa, Koichi Matsuo, Wenlin Du, Taketo Yamada, Masashi Hozumi, Daiju Ichikawa, Yutaka Hattori
Article
Cell Biology
Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Hirokazu Sugino, Tsukasa Oikawa, Hisataka Sabe
CELL COMMUNICATION AND SIGNALING
(2018)
Article
Multidisciplinary Sciences
Shigeru Hashimoto, Shotaro Furukawa, Ari Hashimoto, Akio Tsutaho, Akira Fukao, Yurika Sakamura, Gyanu Parajuli, Yasuhito Onodera, Yutaro Otsuka, Haruka Handa, Tsukasa Oikawa, Soichiro Hata, Yoshihiro Nishikawa, Yusuke Mizukami, Yuzo Kodama, Masaaki Murakami, Toshinobu Fujiwara, Satoshi Hirano, Hisataka Sabe
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Dermatology
Mika Watanabe, Hideyuki Kosumi, Shin-Ichi Osada, Shota Takashima, Yunan Wang, Wataru Nishie, Tsukasa Oikawa, Tomonori Hirose, Hiroshi Shimizu, Ken Natsuga
Summary: COL17 is crucial for maintaining epidermal cell polarity, as its deficiency can lead to asymmetric cell division and affect the health of epidermal cells.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Immunology
Hiroaki Kida, Jing-Jing Jiang, Yuichiro Matsui, Ikuko Takahashi, Rie Hasebe, Daisuke Kawamura, Takeshi Endo, Hiroki Shibayama, Makoto Kondo, Yasuhiko Nishio, Kinya Nishida, Yoshihiro Matsuno, Tsukasa Oikawa, Shimpei Kubota, Shintaro Hojyo, Norimasa Iwasaki, Shigeru Hashimoto, Yuki Tanaka, Masaaki Murakami
Summary: Dupuytren's contracture (DC) is an inflammatory fibrosis without effective treatment. This study focused on two SNPs in SFRP4 associated with DC and investigated their relationship with the IL-6 amplifier. Knockdown of SFRP4 suppressed the activation of the IL-6 amplifier, while overexpression of SFRP4 induced NF-kappa B activation. SFRP4 expression was significantly increased in fibroblasts from DC patients bearing the risk alleles. These findings suggest that SFRP4 could be a potential therapeutic target for inflammatory diseases, including DC.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Cell Biology
Yuichi Mazaki, Yasuhito Onodera, Tsunehito Higashi, Takahiro Horinouchi, Tsukasa Oikawa, Hisataka Sabe
CELL COMMUNICATION AND SIGNALING
(2017)