期刊
EBIOMEDICINE
卷 27, 期 -, 页码 247-257出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ebiom.2017.12.002
关键词
Aortic dissection; Glucocorticoid; Vascular remodeling; TNF-alpha; Soluble TNF-RII
资金
- National Natural Science Foundation of China [81700430, 81273522]
Increasing researches suggest that inflammatory response is involved in vascular remodeling, which plays an important role in the development of aortic dissection. Glucocorticoids have been widely used in the clinical practice due to its powerful and effective anti-inflammatory property. However, the potential relationship between glucocorticoids and aortic dissection was still obscure. This study sought to elucidate the effect of glucocorticoids on the development and progression of aortic dissection, and the potential mechanism involved. Serum cortisol in aortic dissection patients was significantly higher than that in non-ruptured aortic aneurysm patients and healthy volunteers by radioimmunoassay. In modified C57BL/6 mouse model of aortic dissection, glucocorticoids reduced the incidence of aortic dissection and protected the collagen from degradation. Furthermore, glucocorticoids inhibited the TNF-alpha secretion of THP-1 monocytes, decreased the migration, phenotype switch from contractile type to synthetic type, and the apoptosis of human aortic smooth muscle cells induced by TNF-alpha. Finally, TNF-sRII was identified as an important cytokine in cellular interaction that participated in vascular remodeling by targeting the p38 MAPK-HSP27 pathway. These results indicate that glucocorticoids inhibit the incidence of aortic dissection by decreasing the TNF-alpha secretion and increasing the uncombined TNF-sRII, positively participating in vascular remodeling. (c) 2017 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
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