期刊
MSPHERE
卷 3, 期 1, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/mSphere.00568-17
关键词
Histophilus somni; Mannheimia haemolytica; Pasteurella multocida; aminoglycoside-modifying enzymes; aminoglycosides; antibiotic resistance; bovine respiratory disease; cosmid library; integrative and conjugative element; spectinomycin
类别
资金
- NSERC
- Alberta Livestock and Meat Agency (ALMA)
- Beef Cattle Research Council (BCRC)-Agriculture and Agri-Food Canada beef cluster
A novel variant of the AAD(3 '') class of aminoglycoside-modifying enzymes was discovered in fatal bovine respiratory disease-associated pathogens Pasteurella multocida and Histophilus somni. The aadA31 gene encodes a spectinomycin/streptomycin adenylyltransferase and was located in a variant of the integrative and conjugative element ICEMh1, a mobile genetic element transmissible among members of the family Pasteurellaceae. The gene was also detected in Mannheimia haemolytica from a case of porcine pneumonia and in Moraxella bovoculi from a case of keratoconjunctivitis. IMPORTANCE Aminoglycosides are important antimicrobials used worldwide for prophylaxis and/or therapy in multiple production animal species. The emergence of new resistance genes jeopardizes current pathogen detection and treatment methods. The risk of resistance gene transfer to other animal and human pathogens is elevated when resistance genes are carried by mobile genetic elements. This study identified a new variant of a spectinomycin/streptomycin resistance gene harbored in a self-transmissible mobile element. The gene was also present in four different bovine pathogen species.
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