期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 4, 期 11, 页码 3691-3703出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b01017
关键词
biomaterials; polymers; polyesters; microfabrication; soft lithography; scaffolds; shape-memory; photo-cross-linkable
资金
- Canadian Institutes of Health Research (CIHR) [MOP-137107]
- National Sciences and Engineering Research Council of Canada (NSERC) Steacie Fellowship
- NSERC Vanier Scholarship
- NSERC Ontario Graduate Scholarship
- Training Program in Organ-on-a-Chip Engineering & Entrepreneurship (TOeP) NSERC CREATE Scholarship
- NSERC Alexander Graham Bell Canada Graduate Scholarships-Doctoral Program (CGS D)
- NSERC Postgraduate Scholarships-Doctoral Program (PGS D)
- CIHR [MOP-126027]
- Heart and Stroke Foundation [G-16-00012711]
- NSERC [RGPIN-2015-05952]
- Canada Foundation for Innovation Grant [226225]
- Ontario Institute for Regenerative Medicine New Ideas Grant [500235]
- University of Toronto McLean Award
Using the methods described herein, we have demonstrated how scaffolds can be designed for a number of applications including tissue engineering, biomedical devices and injectable tissues. Details on the methods of polymerization and physical and chemical characterization of poly(octamethylene maleate (anhydride) citrate (POMaC) are described. Two POMaC polymer recipes with different monomer ratios of maleic anhydride and citric acid were synthesized and compared. Mechanical testing was performed on scaffolds of two distinct anisotropic designs to show how scaffold design influences the apparent elasticity in the long and short axis. POMaC scaffolds of various patterns and geometries were fabricated to demonstrate: (1) scaffold function can be determined by scaffold design (e.g., inherent shape-memory or self-assembling tubular structures), and (2) the soft lithography approach to fabricating biodegradable elastomers described here can be used to suit a number of different potential applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据