Article
Psychiatry
Adrian Andrzej Chrobak, Anna Krupa, Dominika Dudek, Marcin Siwek
Summary: The study revealed a low overlap between different assessment tools for neurological soft signs, which limits reproducibility and hinders the unification of knowledge from existing data. The diversity in NSS assessment tools suggests the need for further research on the non-localizable nature of NSS.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Christina J. Herold, Celine Z. Duval, Johannes Schroeder
Summary: Neurological soft signs in patients with chronic schizophrenia deteriorate in the long-term course, possibly due to a decrease in executive functions and logical memory. Motor coordination and integrative functions showed significant increases in NSS during follow-up, while other symptoms remained relatively stable.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Review
Clinical Neurology
Eva-Maria Tsapakis, Calypso A. A. Mitkani, Konstantinos N. N. Fountoulakis
Summary: Neurological soft signs are possible indicators of abnormal neurodevelopment and neural connectivity. They are not exclusive to schizophrenia, but they appear to be a trait characteristic in psychosis and can serve as an objective measure for serious psychiatric disorder assessment. Neurocognitive deficits may contribute to the construct of NSS, and they may help identify individuals at risk of developing schizophrenia later in life.
Article
Psychiatry
Xin-Lu Cai, Yong-Ming Wang, Yi Wang, Han-Yu Zhou, Jia Huang, Ya Wang, Simon S. Y. Lui, Arne Moller, Karen S. Y. Hung, Henry K. F. Mak, Pak C. Sham, Eric F. C. Cheung, Raymond C. K. Chan
Summary: The study revealed correlations between neurological soft signs (NSS) and cerebellar-cerebral resting-state functional connectivity (rsFC) in schizophrenia patients, suggesting a link with negative symptoms. The uncoupling of rsFC between the cerebellum and prefrontal regions may underlie the expression of NSS and provide a potential neural pathway for alleviating negative symptoms.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Cristian Petrescu, Ioana R. R. Papacocea, Crisanda Vilciu, Oana A. A. Mihalache, Diana M. M. Vlad, Gabriela Marian, Brindusa E. E. Focseneanu, Cristian T. T. Sima, Constantin A. A. Ciobanu, Sorin Riga, Adela M. M. Ciobanu
Summary: This study aims to compare the profile of neurological soft signs in patients with predominantly negative symptoms of schizophrenia with patients who do not present a predominance of negative symptoms, as well as to assess the impact of treatment on the neurological function of these patients.
Article
Psychiatry
Li Kong, Christina J. Herold, Silke Bachmann, Johannes Schroeder
Summary: This study found that neurological soft signs (NSS) are associated with disrupted network connectivity in patients with first-episode schizophrenia, and these associations change over time during the course of the disorder.
Article
Clinical Neurology
Adrian Andrzej Chrobak, Katarzyna Siuda-Krzywicka, Bartosz Bohaterewicz, Anna Maria Sobczak, Anna Ceglarek, Anna Tereszko, Anna Starowicz-Filip, Magdalena Fafrowicz, Tadeusz Marek, Marcin Siwek, Dominika Dudek, Zbigniew Soltys, Grzegorz Przemyslaw Siwek
Summary: This study utilized cluster analysis to investigate abnormalities in neurological and cerebellar soft signs in SZ and BD patients, revealing a potential relationship between implicit motor learning and these abnormalities. Results indicated deficits in motor functioning in SZ and BD patients in the form of neurological and cerebellar soft signs.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Konstantinos N. Fountoulakis, Panagiotis Panagiotidis, Thomas Tegos, Vasileios Kimiskidis, Ioannis Nimatoudis
Summary: This study aimed to develop a neurobiological diagnostic index by combining advanced parental age at delivery and neurological soft signs, without considering clinical symptoms. The findings suggest that the Psychotic Neurological Index may serve as an easily obtainable diagnostic neurobiological marker with identifiable properties to distinguish patients with schizophrenia from healthy controls with high efficacy.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Elena M. Bonke, Amanda Clauwaert, Stefan M. Hillmann, Uta Tacke, Caroline Seer, Eukyung Yhang, Yorghos Tripodis, Stian B. Sandmo, Tim L. T. Wiegand, David Kaufmann, Elisabeth Kaufmann, Sutton B. Richmond, Malo Gaubert, Johanna Seitz-Holland, Alexander Leemans, Stephan P. Swinnen, Roald Bahr, Ofer Pasternak, Florian Heinen, Inga K. Koerte, Michaela V. Bonfert, Jolien Gooijers
Summary: This study investigates the relationship between neurological soft signs (NSS) and postural control in adolescent athletes, and suggests that force plate measures can provide relevant quantitative information in addition to qualitative assessments.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Psychiatry
Simon S. Y. Lui, Stanley S. L. Yip, Ya Wang, Karen S. Y. Hung, Karen K. Y. Ho, Kirby C. M. Tsang, Hera K. H. Yeung, Eric F. C. Cheung, Raymond C. K. Chan
Summary: The study investigated the trajectory of neurological soft signs (NSS) in schizophrenia patients and found that NSS worsened over time in treatment-resistant patients. This suggests that NSS may be useful in identifying treatment resistance in first-episode schizophrenia patients, reflecting the development of underlying neuropathology.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Health Care Sciences & Services
Cristian Petrescu, Diana M. Petrescu, Gabriela Marian, Brindusa E. Focseneanu, Floris Petru Iliuta, Constantin Alexandru Ciobanu, Serban Papacocea, Adela M. Ciobanu
Summary: This article reviews the impact of Neurological Soft Signs (NSS) on schizophrenia symptoms, neuroleptic treatment, and cerebral structural changes. The results suggest that NSS are common in schizophrenia patients and may have a genetic component.
Article
Neurosciences
Elena M. Bonke, Michaela Bonfert, Stefan M. Hillmann, Johanna Seitz-Holland, Malo Gaubert, Tim L. T. Wiegand, Alberto De Luca, Kang Ik K. Cho, Stian B. Sandmo, Eukyung Yhang, Yorghos Tripodis, Caroline Seer, David Kaufmann, Elisabeth Kaufmann, Marc Muehlmann, Jolien Gooijers, Alexander P. Lin, Alexander Leemans, Stephan P. Swinnen, Roald Bahr, Martha E. Shenton, Ofer Pasternak, Uta Tacke, Florian Heinen, Inga K. Koerte
Summary: This study investigates the association between neurological soft signs (NSS) and brain structure alterations in physically trained adolescents. The results show that adolescents with NSS have higher gyrification in specific brain regions and lower fractional anisotropy (FAt) and higher axial and radial diffusivity (ADt, RDt) in widespread areas. This suggests that NSS in adolescents are associated with brain structure alterations.
Review
Psychiatry
Genelle D. Samson, Adrienne C. Lahti, Nina V. Kraguljac
Summary: Neurological soft signs (NSS) are common in patients with schizophrenia, with the basal ganglia and cerebellum implicated as structural substrates. Somatomotor and somatosensory regions, as well as areas involved in visual processing and spatial orientation, are suggested to underlie NSS in psychosis spectrum disorders. Dysfunction of frontoparietal and cerebellar networks has also been implicated. However, it remains unclear if white matter integrity deficits or neurometabolic alterations contribute to NSS in schizophrenia. Knowledge about the temporal evolution of NSS and associated brain signatures is limited. Future studies addressing these gaps will be important.
Article
Psychiatry
Silke Bachmann, Michaela Beck, Dai-Hua Tsai, Friederike Haupt
Summary: Neurological soft signs have been widely studied in psychiatric disease, with assessment easily performed and possibly providing useful information about disease course. In this pilot study, it was found that NSS scores significantly increased in individuals aged 50 and above, primarily due to motor signs. Gender and cognitive functioning did not show any correlation with changes in scores.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Marina P. Valerio, Julieta Lomastro, Ana Igoa, Diego J. Martino
Summary: Recent research examined the relationship between neurological soft signs (NSS) and various variables in bipolar disorder (BD) patients. The study found that NSS were negatively associated with years of education and increased with age. Additionally, BD type I patients had higher NSS scores compared to BD type II patients. NSS were also correlated with lower premorbid IQ and poorer performance in attention, language, and executive functions. However, when included in a multiple regression model, NSS did not significantly contribute to functional outcomes.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)