期刊
ORGANIC CHEMISTRY FRONTIERS
卷 5, 期 14, 页码 2214-2218出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00438b
关键词
-
资金
- Ministry of Education (Singapore)
- Nanyang Technological University [RG114/15, MOE2016-T2-2-043]
A cobalt-catalyzed directed ortho C-H methylation reaction of arenes has been achieved using readily available methyl tosylate as a methylating agent. An in situ-generated cobalt-N-heterocyclic carbene catalyst in combination with neopentylmagnesium bromide promotes the methylation at room temperature. The reaction is applicable to various substrates bearing nitrogen directing groups such as N-aryl imine, N-H imine, and 2-pyridyl groups. The present protocol also allows for facile introduction of a trideuteriomethyl group into arenes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据