期刊
ORGANIC CHEMISTRY FRONTIERS
卷 5, 期 10, 页码 1622-1627出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00184g
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Oxindoles display a diverse pattern of reactivity upon reaction with different classes of amino alcohols via the borrowing hydrogen process. Whereas the reaction with N-acetyl amino alcohols leads to C3 alkylation, the reaction with N-alkyl amino alcohols results in the formation of synthetically useful -aryl-lactams via a remarkably facile oxindole ring-opening reaction. Reactions occurred with quantitative conversion and selectivity under relatively mild reaction conditions.
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