期刊
ONCOIMMUNOLOGY
卷 7, 期 5, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2018.1424672
关键词
CXCL9; ovarian carcinoma; T effector memory cells; tumor-associated macrophages
资金
- Universitatsklinikum Giessen und Marburg (UKGM)
The accumulation of intratumoral CD8(+) T cells is associated with the survival of high grade serous ovarian carcinoma patients, but it is unclear which CD8(+) T cell subsets contribute to this effect and how they are affected by the peritoneal tumor microenvironment. Here, we provide evidence for a functional link between long relapse-free survival, accumulation of CD8(+) effector memory T (T-EM) cells in peritoneal effusion (ascites), and the level of the CD8(+) T-EM attracting chemokine CXCL9, produced by macrophages as a major source. We also propose a novel mechanism by which the tumor microenvironment could contribute to T cell dysfunction and shorter survival, i.e., diminished expression levels of essential signaling proteins, including STAT5B, PLC gamma 1 and NFATc2. CD8(+) T-EM cells in ascites, CXCL9 levels and the expression of crucial signal transduction proteins may therefore be important biomarkers to gauge the efficiency of immune therapies and potentially represent therapeutic targets.
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